Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Udaiyappan Janakiraman"'
Autor:
Mark A. Nelson, Kohji Fukunaga, Udaiyappan Janakiraman, Chinnasamy Dhanalakshmi, Aubin Moutal, Lisa Boinon, Jie Yu, Rajesh Khanna
Publikováno v:
Neurobiology of Disease, Vol 143, Iss, Pp 105006-(2020)
Neurobiol Dis
Neurobiol Dis
T-type calcium channels, in the central nervous system, are involved in the pathogenesis of many neurodegenerative diseases, including TAF1 intellectual disability syndrome (TAF1 ID syndrome). Here, we evaluated the efficacy of a novel T-type Ca2+ ch
Autor:
Chinnasamy Dhanalakshmi, Udaiyappan Janakiraman, Mark A. Nelson, Aubin Moutal, Rajesh Khanna, Kohji Fukunaga
Publikováno v:
Neurobiology of disease
Neurobiology of Disease, Vol 149, Iss, Pp 105224-(2021)
Neurobiology of Disease, Vol 149, Iss, Pp 105224-(2021)
The TATA-box binding protein associated factor 1 (TAF1) is part of the TFIID complex that plays a key role during the initiation of transcription. Variants of TAF1 are associated with neurodevelopmental disorders. Previously, we found that CRISPR/Cas
Autor:
Chinnasamy Dhanalakshmi, Thamilarasan Manivasagam, Musthafa Mohamed Essa, Udaiyappan Janakiraman, Gilles J. Guillemin, Arokiasamy Justin Thenmozhi, Byoung Joon Song
Publikováno v:
Physiology & Behavior. 173:132-143
Depression is frequently encountered during Parkinson's disease (PD) as a non-motor feature, which has been reported to cause and exaggerate motor deficits and neurodegenerative events in experimental PD models. We studied the effect of chronic mild
Autor:
Shelby N. Batchelor, Mark A. Nelson, Udaiyappan Janakiraman, Annaduri Anandhan, Lisa Boinon, Jie Yu, Aubin Moutal, Rajesh Khanna, Dhanalakshmi Chinnasamy
Publikováno v:
Neurobiol Dis
Neurobiology of Disease, Vol 132, Iss, Pp-(2019)
Neurobiology of Disease, Vol 132, Iss, Pp-(2019)
TAF1/MRSX33 intellectual disability syndrome is an X-linked disorder caused by loss-of-function mutations in the TAF1 gene. How these mutations cause dysmorphology, hypotonia, intellectual and motor defects is unknown. Mouse models which have embryon
Autor:
Rajesh Khanna, Jie Yu, Anandhan Annadurai, Shelby N. Batchelor, Aubin Moutal, Udaiyappan Janakiraman, Mark A. Nelson
TAF1 intellectual disability syndrome is an X-linked disorder caused by loss-of-function mutations in the TAF1 gene. How these mutations cause dysmorphology, hypotonia, intellectual and motor defects is unknown. Mouse models which have embryonically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a2c55a6a6d12d34c747b05be05abf6
Autor:
Rajamani Barathidasan, Udaiyappan Janakiraman, Thamilarasan Manivasagam, Gilles J. Guillemin, Mohammed A. S. Khan, Chidambaram Saravanababu, Arokiasamy Justin Thenmozhi, Musthafa Mohamed Essa
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 1, p e0146671 (2016)
PLoS ONE, Vol 11, Iss 1, p e0146671 (2016)
Parkinson's disease (PD) is regarded as a movement disorder mainly affecting the elderly population and occurs due to progressive loss of dopaminergic (DAergic) neurons in nigrostriatal pathway. Patients suffer from non-motor symptoms (NMS) such as d
Autor:
Udaiyappan Janakiraman, Mohammed Abdul Sattar Khan, Thamilarasan Manivasagam, Musthafa Mohamed Essa, Arokiasamy Justin Thenmozhi, Gilles J. Guillemin, Ameer Kalandar, Chinnasamy Dhanalakshmi
Publikováno v:
Neurochemical research. 41(8)
Vanillin (4-hydroxy-3-methoxybenzaldehyde), a pleasant smelling organic aromatic compound, is widely used as a flavoring additive in food, beverage, cosmetic and drug industries. It is reported to cross the blood brain barrier and also displayed anti
Autor:
Ranganathan Chidambaram, Udaiyappan Janakiraman, Veerapan Venkatesh Gobi, Giles J Guillemin, Arokiasamy Justin Thenmozhi, Saravana Babu Chidambaram, Musthafa Mohamed Essa, Thamilarasan Manivasagam, Srinivasagam Rajasankar, Muthu Ramkumar
Publikováno v:
Pharmacognosy Magazine
Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder (NDD) associated with the loss of dopaminergic neurons in the substantia nigra and subsequently has an effect on motor function and coordination. The pathology of PD is