Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Todd L. Edwards"'
Autor:
Michael G. Levin, Neil M Davies, Julie Lynch, Pradeep Natarajan, Todd L. Edwards, Philip S. Tsao, Daniel J. Rader, Dipender Gill, Benjamin F. Voight, Kyung Min Lee, Derek Klarin, Kyong-Mi Chang, Venexia M Walker, Scott M. Damrauer, Themistocles L. Assimes, Jacklyn N. Hellwege, J. Michael Gaziano, Adriana M. Hung, Jacob M. Keaton
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: We aimed to estimate the effect of blood pressure (BP) traits and BP-lowering medications (via genetic proxies) on peripheral artery disease. Approach and Results: Genome-wide association studies summary statistics were obtained for BP, pe
Autor:
Derek Klarin, Shefali Setia Verma, Renae Judy, Ozan Dikilitas, Brooke N. Wolford, Ishan Paranjpe, Michael G. Levin, Cuiping Pan, Catherine Tcheandjieu, Joshua M. Spin, Julie Lynch, Themistocles L. Assimes, Linn Åldstedt Nyrønning, Erney Mattsson, Todd L. Edwards, Josh Denny, Eric Larson, Ming Ta Michael Lee, David Carrell, Yanfei Zhang, Gail P. Jarvik, Ali G. Gharavi, John Harley, Frank Mentch, Jennifer A. Pacheco, Hakon Hakonarson, Anne Heidi Skogholt, Laurent Thomas, Maiken Elvestad Gabrielsen, Kristian Hveem, Jonas Bille Nielsen, Wei Zhou, Lars Fritsche, Jie Huang, Pradeep Natarajan, Yan V. Sun, Scott L. DuVall, Daniel J. Rader, Kelly Cho, Kyong-Mi Chang, Peter W.F. Wilson, Christopher J. O’Donnell, Sekar Kathiresan, Salvatore T. Scali, Scott A. Berceli, Cristen Willer, Gregory T. Jones, Matthew J. Bown, Girish Nadkarni, Iftikhar J. Kullo, Marylyn Ritchie, Scott M. Damrauer, Philip S. Tsao, J. Michael Gaziano, Rachel Ramoni, Jean Beckham, Jim Breeling, Grant Huang, Sumitra Muralidhar, J.P. Casas Romero, Jennifer Moser, Stacey B. Whitbourne, Jessica V. Brewer, John Concato, Stuart Warren, Dean P. Argyres, Brady Stephens, Mary T. Brophy, Donald E. Humphries, Nhan Do, Shahpoor Shayan, Xuan-Mai T. Nguyen, Saiju Pyarajan, Elizabeth Hauser, Yan Sun, Hongyu Zhao, Peter Wilson, Rachel McArdle, Louis Dellitalia, Clement J. Zablocki, Jeffrey Whittle, John Wells, Salvador Gutierrez, Gretchen Gibson, Laurence Kaminsky, Gerardo Villareal, Scott Kinlay, Junzhe Xu, Mark Hamner, Kathlyn Sue Haddock, Sujata Bhushan, Pran Iruvanti, Michael Godschalk, Zuhair Ballas, Malcolm Buford, Stephen Mastorides, Jon Klein, Nora Ratcliffe, Hermes Florez, Alan Swann, Maureen Murdoch, Peruvemba Sriram, Shing Shing Yeh, Ronald Washburn, Darshana Jhala, Samuel Aguayo, David Cohen, Satish Sharma, John Callaghan, Kris Ann Oursler, Mary Whooley, Sunil Ahuja, Amparo Gutierrez, Ronald Schifman, Jennifer Greco, Michael Rauchman, Richard Servatius, Mary Oehlert, Agnes Wallbom, Ronald Fernando, Timothy Morgan, Todd Stapley, Scott Sherman, Gwenevere Anderson, Philip Tsao, Elif Sonel, Edward Boyko, Laurence Meyer, Samir Gupta, Joseph Fayad, Adriana Hung, Jack Lichy, Robin Hurley, Brooks Robey, Robert Striker
Publikováno v:
Circulation
Supplemental Digital Content is available in the text.
Background: Abdominal aortic aneurysm (AAA) is an important cause of cardiovascular mortality; however, its genetic determinants remain incompletely defined. In total, 10 previously identifi
Background: Abdominal aortic aneurysm (AAA) is an important cause of cardiovascular mortality; however, its genetic determinants remain incompletely defined. In total, 10 previously identifi
Autor:
Dan M. Roden, Nancy J. Cox, V. Eric Kerchberger, Todd L. Edwards, Neil S Zheng, Juan Zhao, Wei-Qi Wei, QiPing Feng, Joshua C. Denny, C. Michael Stein
Publikováno v:
Journal of the American Medical Informatics Association : JAMIA
Objective Developing algorithms to extract phenotypes from electronic health records (EHRs) can be challenging and time-consuming. We developed PheMap, a high-throughput phenotyping approach that leverages multiple independent, online resources to st
Autor:
David J. Stott, Christopher J. O'Donnell, Nuno R. Zilhão, Eric A. Whitsel, Fangui Sun, Leslie A. Lange, Xiuqing Guo, Kerri L. Wiggins, Hanfei Xu, Aishwarya Sundaresan, Dennis O. Mook-Kanamori, Christy L. Avery, Albert V. Smith, Xiaohui Li, Til Stürmer, Ayush Giri, Raymond Noordam, Joshua C. Bis, Walter Palmas, Adolfo Correa, Laura M. Raffield, Peter Rossing, Rikki M. Tanner, Tarunveer S. Ahluwalia, James A. Stewart, Helen R. Warren, Jie Yao, Colleen M. Sitlani, Vilmundur Gudnason, Adrienne Cupples, James S. Floyd, Bruce M. Psaty, Jerome I. Rotter, Marguerite R. Irvin, Jacklyn N. Hellwege, Donna K. Arnett, Adriana M. Hung, Ching-Ti Liu, Nita A. Limdi, Stella Trompet, Todd L. Edwards, Lenore J. Launer, J. Wouter Jukema, Ian Ford
Publikováno v:
Am J Hypertens
American Journal of Hypertension, 32(12), 1146-1153. OXFORD UNIV PRESS
American journal of hypertension, vol 32, iss 12
American Journal of Hypertension, 32(12), 1146-1153. OXFORD UNIV PRESS
American journal of hypertension, vol 32, iss 12
BACKGROUND Only a handful of genetic discovery efforts in apparent treatment-resistant hypertension (aTRH) have been described. METHODS We conducted a case–control genome-wide association study of aTRH among persons treated for hypertension, using
Autor:
Adriana M. Hung, Danish Saleheen, Jennifer Lee, Jennifer E. Huffman, John Concato, Kyung Min Lee, Peter W.F. Wilson, J. Michael Gaziano, Julie Lynch, Pradeep Natarajan, Philip S. Tsao, Todd L. Edwards, Daniel J. Rader, Derek Klarin, S. Matthew Freiberg, Michael G. Levin, Huaying Fang, Scott L. DuVall, Rachel L. Kember, Scott M. Damrauer, Christopher J. O'Donnell, Qing Shao, Yan V. Sun, Alexander G. Bick, Themistocles L. Assimes, Hua Tang, Cassianne Robinson-Cohen, Leland E. Hull, Jie Huang, Sekar Kathiresan, Elvis A. Akwo, Kelly Cho, Donald R. Miller, Otis D. Wilson, Ayush Giri, Kyong-Mi Chang
Publikováno v:
Circulation. 140:1031-1040
Background: Approximately 13% of black individuals carry 2 copies of the apolipoprotein L1 ( APOL1 ) risk alleles G1 or G2, which are associated with 1.5- to 2.5-fold increased risk of chronic kidney disease. There have been conflicting reports as to
Autor:
Xingyi Guo, Reid M. Ness, Martha J. Shrubsole, Xiangzhu Zhu, Douglas L. Seidner, Yixing Jiang, Ayush Giri, Edward Giovannucci, Todd L. Edwards, Qi Dai, Jing Zhao
Publikováno v:
British Journal of Cancer
Background We aimed to evaluate the associations between calcium and various stages of colorectal carcinogenesis and whether these associations are modified by the calcium to magnesium (Ca:Mg) ratio. Methods We tested our hypotheses in the prostate l
Autor:
Adriana M. Hung, Ran Tao, Peter W.F. Wilson, James M. Luther, Nancy J. Brown, Cassianne Robinson-Cohen, Christianne L. Roumie, Shailja C. Shah, Elvis A. Akwo, Edward D. Siew, T. Alp Ikizler, Cecilia P. Chung, Ayush Giri, Todd L. Edwards, Bryce X Rowan, Csaba P. Kovesdy, J. Michael Gaziano, Digna R. Velez Edwards, P.S. Tsao, VA Million Veteran Program, Megan M. Shuey, Otis D. Wilson, Jacklyn N. Hellwege, Christopher J. O'Donnell
Publikováno v:
Hypertension
Apparent treatment-resistant hypertension (ATRH) has been linked to end-stage kidney disease (ESKD) and cardiovascular disease. We tested the hypothesis that the effect of ATRH on ESKD is greater in Black patients than in White patients and investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636a3bed56e5f56a1a12a37b5aa59871
https://europepmc.org/articles/PMC8364328/
https://europepmc.org/articles/PMC8364328/
Autor:
Ana Osorio, Fiona Bruinsma, Andrew J. Li, Janine Senz, Stacey J. Winham, Michael E. Carney, Deborah J. Thompson, Xifeng Wu, Susan J. Ramus, Alicia A. Tone, Robert P. Edwards, Chu Chen, Daniel D. Buchanan, Rüdiger Klapdor, Diether Lambrechts, Anthony N. Karnezis, Ralf Bützow, Graham G. Giles, Jolanta Kupryjanczyk, James D. Brenton, Pamela J. Thompson, Joseph L. Kelley, Hui Cai, Dylan M. Glubb, Peter Hillemanns, Veronica Wendy Setiawan, Reidun K. Kopperud, Francesmary Modugno, Rodney J. Scott, Karen H. Lu, Andreas du Bois, Weiva Sieh, Clara Bodelon, Katharina Bischof, Sarah E. Ferguson, Ignace Vergote, Todd L. Edwards, Nadeem Siddiqui, Jennifer A. Doherty, Celeste Leigh Pearce, David G. Huntsman, Håkan Olsson, Ailith Ewing, Tjoung-Won Park-Simon, Harvey A. Risch, Taymaa May, Soo Hwang Teo, Elizabeth G. Holliday, Penelope M. Webb, Lukasz Michael Szafron, Alexander Hein, Martin Köbel, Marjorie J. Riggan, Madhuri Koti, Ahmad Alsulimani, Matthias W. Beckmann, Heli Nevanlinna, Domenico Palli, Melissa C. Larson, Emily White, Ingo B. Runnebaum, Robert A. Vierkant, Elza Khusnutdinova, Jolanta Lissowska, Andrew Berchuck, Rosalind Glasspool, Drakoulis Yannoukakos, Alison M. Dunning, Rosario Tumino, Mia M. Gaudet, Alice S. Whittemore, Anna Jakubowska, Marcus Q. Bernardini, Jennifer B. Permuth, Kunle Odunsi, Aleksandra Gentry-Maharaj, Florentia Fostira, Philipp Harter, Rebecca Sutphen, Sandra Orsulic, Beata Spiewankiewicz, Susanne K. Kjaer, Jessica N. McAlpine, Valerie McGuire, Julie M. Cunningham, Jeffrey Killeen, Christine M. Friedenreich, Estrid Høgdall, George Fountzilas, Michelle A.T. Hildebrandt, Katja K.H. Aben, Tomasz Huzarski, Frédéric Amant, Zhaoming Wang, James M. Flanagan, Timothy R. Rebbeck, Joseph H. Rothstein, Clemens Liebrich, Immaculata De Vivo, Linda Titus, Anna deFazio, Jan Gawełko, Irene Konstantopoulou, Adriaan Vanderstichele, Stephen J. Chanock, Jenny Lester, Amanda B. Spurdle, Allan Jensen, Claus Høgdall, Daniela Annibali, Amalia Mattiello, Peter Kraft, Loic Le Marchand, Line Bjørge, Marina Bermisheva, Agnieszka Podgorska, John Attia, Tracy A. O'Mara, Shashikant Lele, Thomas A. Sellers, Bo Gao, Holly R. Harris, Shan Wang-Gohrke, Lingeng Lu, Louise A. Brinton, Alessandra Macciotta, Digna R. Velez Edwards, Peter A. Fasching, Marc T. Goodman, Linda S. Cook, Constance Turman, Jacek Gronwald, Liv Cecilie Vestrheim Thomsen, Matthias Dürst, Kirsten B. Moysich, Usha Menon, Dong Liang, Arif B. Ekici, Bozena Konopka, Aurelio Barricarte, Thilo Dörk, Stefanie Burghaus, Michael Jones, Loren Lipworth, Zhihua Chen, Xiaoqing Chen, Alison Brand, Iain A. McNeish, Tanja Pejovic, Florian Heitz, Beth Y. Karlan, Anthony J. Swerdlow, Anna H. Wu
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention, 30, 1, pp. 217-228
Cancer Epidemiology, Biomarkers & Prevention, 30, 217-228
Cancer epidemiology, biomarkers & prevention, 30(1), 217-228. American Association for Cancer Research Inc.
Glubb, D M, Thompson, D J, Aben, K K, Alsulimani, A, Amant, F, Annibali, D, Attia, J, Barricarte, A, Beckmann, M W, Berchuck, A, Bermisheva, M, Bernardini, M Q, Bischof, K, Bjørge, L, Bodelon, C, Brand, A H, Brenton, J D, Brinton, L A, Bruinsma, F, Buchanan, D D, Burghaus, S, Bützow, R, Cai, H, Carney, M E, Chanock, S J, Chen, C, Chen, X, Chen, Z, Cook, L S, Cunningham, J M, De Vivo, I, Defazio, A, Doherty, J A, Dork, T, Du Bois, A, Dunning, A M, Durst, M, Edwards, T, Edwards, R P, Ekici, A B, Ewing, A, Fasching, P A, Ferguson, S, Flanagan, J M, Fostira, F, Fountzilas, G, Friedenreich, C M, Gao, B, Gaudet, M M, Gawełko, J, Gentry-maharaj, A, Giles, G G, Glasspool, R, Goodman, M T, Gronwald, J, Harris, H R, Harter, P, Hein, A, Heitz, F, Hildebrandt, M A T, Hillemanns, P, Høgdall, E, Høgdall, C K, Holliday, E G, Huntsman, D G, Huzarski, T, Jakubowska, A, Jensen, A, Jones, M E, Karlan, B Y, Karnezis, A, Kelley, J L, Khusnutdinova, E, Killeen, J L, Kjaer, S K, Klapdor, R, Köbel, M, Konopka, B, Konstantopoulou, I, Kopperud, R K, Koti, M, Kraft, P, Kupryjanczyk, J, Lambrechts, D, Larson, M C, Le Marchand, L, Lele, S, Lester, J, Li, A J, Liang, D, Liebrich, C, Lipworth, L, Lissowska, J, Lu, L, Lu, K H, Macciotta, A, Mattiello, A, May, T, Mcalpine, J N, Mcguire, V, Mcneish, I A, Menon, U, Modugno, F, Moysich, K B, Nevanlinna, H, Odunsi, K, Olsson, H, Orsulic, S, Osorio, A, Palli, D, Park-simon, T, Pearce, C L, Pejovic, T, Permuth, J B, Podgorska, A, Ramus, S J, Rebbeck, T R, Riggan, M J, Risch, H A, Rothstein, J H, Runnebaum, I B, Scott, R J, Sellers, T A, Senz, J, Setiawan, V W, Siddiqui, N, Sieh, W, Spiewankiewicz, B, Sutphen, R, Swerdlow, A J, Szafron, L M, Teo, S H, Thompson, P J, Thomsen, L C V, Titus, L, Tone, A, Tumino, R, Turman, C, Vanderstichele, A, Velez Edwards, D, Vergote, I, Vierkant, R A, Wang, Z, Wang-gohrke, S, Webb, P M, White, E, Whittemore, A S, Winham, S J, Wu, X, Wu, A H, Yannoukakos, D, Spurdle, A B & O'mara, T A 2021, ' Cross-cancer genome-wide association study of endometrial cancer and epithelial ovarian cancer identifies genetic risk regions associated with risk of both cancers. ', Cancer Epidemiology, Biomarkers & Prevention, vol. 30, no. 1, cebp.0739.2020, pp. 217-228 . https://doi.org/10.1158/1055-9965.EPI-20-0739
Cancer Epidemiology, Biomarkers & Prevention, 30, 217-228
Cancer epidemiology, biomarkers & prevention, 30(1), 217-228. American Association for Cancer Research Inc.
Glubb, D M, Thompson, D J, Aben, K K, Alsulimani, A, Amant, F, Annibali, D, Attia, J, Barricarte, A, Beckmann, M W, Berchuck, A, Bermisheva, M, Bernardini, M Q, Bischof, K, Bjørge, L, Bodelon, C, Brand, A H, Brenton, J D, Brinton, L A, Bruinsma, F, Buchanan, D D, Burghaus, S, Bützow, R, Cai, H, Carney, M E, Chanock, S J, Chen, C, Chen, X, Chen, Z, Cook, L S, Cunningham, J M, De Vivo, I, Defazio, A, Doherty, J A, Dork, T, Du Bois, A, Dunning, A M, Durst, M, Edwards, T, Edwards, R P, Ekici, A B, Ewing, A, Fasching, P A, Ferguson, S, Flanagan, J M, Fostira, F, Fountzilas, G, Friedenreich, C M, Gao, B, Gaudet, M M, Gawełko, J, Gentry-maharaj, A, Giles, G G, Glasspool, R, Goodman, M T, Gronwald, J, Harris, H R, Harter, P, Hein, A, Heitz, F, Hildebrandt, M A T, Hillemanns, P, Høgdall, E, Høgdall, C K, Holliday, E G, Huntsman, D G, Huzarski, T, Jakubowska, A, Jensen, A, Jones, M E, Karlan, B Y, Karnezis, A, Kelley, J L, Khusnutdinova, E, Killeen, J L, Kjaer, S K, Klapdor, R, Köbel, M, Konopka, B, Konstantopoulou, I, Kopperud, R K, Koti, M, Kraft, P, Kupryjanczyk, J, Lambrechts, D, Larson, M C, Le Marchand, L, Lele, S, Lester, J, Li, A J, Liang, D, Liebrich, C, Lipworth, L, Lissowska, J, Lu, L, Lu, K H, Macciotta, A, Mattiello, A, May, T, Mcalpine, J N, Mcguire, V, Mcneish, I A, Menon, U, Modugno, F, Moysich, K B, Nevanlinna, H, Odunsi, K, Olsson, H, Orsulic, S, Osorio, A, Palli, D, Park-simon, T, Pearce, C L, Pejovic, T, Permuth, J B, Podgorska, A, Ramus, S J, Rebbeck, T R, Riggan, M J, Risch, H A, Rothstein, J H, Runnebaum, I B, Scott, R J, Sellers, T A, Senz, J, Setiawan, V W, Siddiqui, N, Sieh, W, Spiewankiewicz, B, Sutphen, R, Swerdlow, A J, Szafron, L M, Teo, S H, Thompson, P J, Thomsen, L C V, Titus, L, Tone, A, Tumino, R, Turman, C, Vanderstichele, A, Velez Edwards, D, Vergote, I, Vierkant, R A, Wang, Z, Wang-gohrke, S, Webb, P M, White, E, Whittemore, A S, Winham, S J, Wu, X, Wu, A H, Yannoukakos, D, Spurdle, A B & O'mara, T A 2021, ' Cross-cancer genome-wide association study of endometrial cancer and epithelial ovarian cancer identifies genetic risk regions associated with risk of both cancers. ', Cancer Epidemiology, Biomarkers & Prevention, vol. 30, no. 1, cebp.0739.2020, pp. 217-228 . https://doi.org/10.1158/1055-9965.EPI-20-0739
Background: Accumulating evidence suggests a relationship between endometrial cancer and ovarian cancer. Independent genome-wide association studies (GWAS) for endometrial cancer and ovarian cancer have identified 16 and 27 risk regions, respectively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05013621ea6b2cd03a98c84750051500
https://hdl.handle.net/2066/231075
https://hdl.handle.net/2066/231075
Autor:
Manuel A. R. Ferreira, Ali Naji, Todd L. Edwards, Anne E. Justice, Marylyn D. Ritchie, John D. Overton, Theodore G. Drivas, Nathan Katz, Ying H. Shen, Yanming Li, Renae Judy, Anastasia Lucas, Amanda Dobbyn, Anurag Verma, Scott M. Damrauer, Daniel J. Rader, Geetha Chittoor, Maria Fasolino, Xinyuan Zhang, Jinbo Chen, Scott A. LeMaire, Alexander H. Li, Joseph H. Breeyear, Rachel L. Kember, Kumardeep Chaudhary, Joseph Park, JoEllen Weaver, Shadi Ahmadmehrabi, Alan Daugherty, Hisashi Sawada, Yuki Bradford, Klaus H. Kaestner, Jeffrey G. Reid, Ron Do, Navya Shilpa Josyula, Golnaz Vahedi, Girish N. Nadkarni, Judy H. Cho, Chen Zhang, Aris Baras, Venkata R M Chavali
Publikováno v:
Nat Med
The clinical impact of rare loss-of-function variants has yet to be determined for most genes. Integration of DNA sequencing data with electronic health records (EHRs) could enhance our understanding of the contribution of rare genetic variation to h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a14e815fc8981dcb22592d74596aad7
https://europepmc.org/articles/PMC8775355/
https://europepmc.org/articles/PMC8775355/
Publikováno v:
Trends in Genetics
The causes for disparities in implementation of precision medicine are complex, due in part to differences in clinical care and a lack of engagement and recruitment of under-represented populations in studies. New tools and large genetic cohorts can