Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Philip T. Liu"'
Autor:
Kislay Parvatiyar, Robert L. Modlin, Euzenir Nunes Sarno, Barry R. Bloom, Genhong Cheng, Rosane M. B. Teles, Philip T. Liu, Maria Teresa Ochoa, Annalisa Legaspi, Aaron Choi, Angeline Tilly Dang, Michel Gilliet
Publikováno v:
JCI insight, vol 4, iss 8
Dang, Angeline Tilly; Teles, Rosane Mb; Liu, Phillip T; Choi, Aaron; Legaspi, Annalisa; Sarno, Euzenir N; et al.(2019). Autophagy links antimicrobial activity with antigen presentation in Langerhans cells.. JCI insight, 4(8). doi: 10.1172/jci.insight.126955. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6584h5s6
Dang, Angeline Tilly; Teles, Rosane Mb; Liu, Phillip T; Choi, Aaron; Legaspi, Annalisa; Sarno, Euzenir N; et al.(2019). Autophagy links antimicrobial activity with antigen presentation in Langerhans cells.. JCI insight, 4(8). doi: 10.1172/jci.insight.126955. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6584h5s6
DC, through the uptake, processing, and presentation of antigen, are responsible for activation of T cell responses to defend the host against infection, yet it is not known if they can directly kill invading bacteria. Here, we studied in human lepro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ce097a4e0c936b51446479a4aae72c
https://escholarship.org/uc/item/6584h5s6
https://escholarship.org/uc/item/6584h5s6
Publikováno v:
PLoS neglected tropical diseases, vol 12, iss 7
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 12, Iss 7, p e0006608 (2018)
Kim, Elliot W; Teles, Rosane MB; Haile, Salem; Liu, Philip T; & Modlin, Robert L. (2018). Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae.. PLoS neglected tropical diseases, 12(7), e0006608. doi: 10.1371/journal.pntd.0006608. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6wg8k5pv
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 12, Iss 7, p e0006608 (2018)
Kim, Elliot W; Teles, Rosane MB; Haile, Salem; Liu, Philip T; & Modlin, Robert L. (2018). Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae.. PLoS neglected tropical diseases, 12(7), e0006608. doi: 10.1371/journal.pntd.0006608. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6wg8k5pv
Background The immune system depends on effector pathways to eliminate invading pathogens from the host in vivo. Macrophages (MΦ) of the innate immune system are armed with vitamin D-dependent antimicrobial responses to kill intracellular microbes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4023b30d30128e6754c351e1e50a0d
https://escholarship.org/uc/item/6wg8k5pv
https://escholarship.org/uc/item/6wg8k5pv
Autor:
Rosane M. B. Teles, Philip T. Liu, Robert L. Modlin, Nathan W. Schmidt, Mirjam Schenk, Matteo Pellegrini, Gerard C. L. Wong, Susan Realegeno, Thomas H. Rea, Kindra M. Kelly-Scumpia, Ernest Y. Lee, Maria Teresa Ochoa, Angeline Tilly Dang, Jing Lu, Euzenir Nunes Sarno
Publikováno v:
PLoS Pathogens
Realegeno, Susan; Kelly-Scumpia, Kindra M; Dang, Angeline Tilly; Lu, Jing; Teles, Rosane; Liu, Philip T; Schenk, Mirjam; Lee, Ernest Y; Schmidt, Nathan W; Wong, Gerard C L; Sarno, Euzenir N; Rea, Thomas H; Ochoa, Maria T; Pellegrini, Matteo; Modlin, Robert L (2016). S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages. PLoS pathogens, 12(6), e1005705. Public Library of Science 10.1371/journal.ppat.1005705
PLoS pathogens, vol 12, iss 6
PLoS Pathogens, Vol 12, Iss 6, p e1005705 (2016)
Realegeno, Susan; Kelly-Scumpia, Kindra M; Dang, Angeline Tilly; Lu, Jing; Teles, Rosane; Liu, Philip T; Schenk, Mirjam; Lee, Ernest Y; Schmidt, Nathan W; Wong, Gerard C L; Sarno, Euzenir N; Rea, Thomas H; Ochoa, Maria T; Pellegrini, Matteo; Modlin, Robert L (2016). S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages. PLoS pathogens, 12(6), e1005705. Public Library of Science 10.1371/journal.ppat.1005705
PLoS pathogens, vol 12, iss 6
PLoS Pathogens, Vol 12, Iss 6, p e1005705 (2016)
Triggering antimicrobial mechanisms in macrophages infected with intracellular pathogens, such as mycobacteria, is critical to host defense against the infection. To uncover the unique and shared antimicrobial networks induced by the innate and adapt
Autor:
Stephanie Kao, Min Qin, Jenny Kim, Laura J. Marinelli, Hermes Garban, George W. Agak, Lisa D. Hisaw, Diane Thiboutot, Philip T. Liu, Aslan Pirouz, Andrew J. Park
Publikováno v:
Annals of Dermatology. 29:688
Background: Acne vulgaris is a disease of the pilosebaceous unit characterized by increased sebum production, hyperkeratinization, and immune responses to Propionibacterium acnes (PA). Here, we explore a possible mechanism by which a lipid receptor,
Autor:
Manali Mehta, Evangelia Komisopoulou, Thomas H. Rea, Euzenir Nunes Sarno, Aria Vazirnia, Thomas G. Graeber, Rosane M. B. Teles, Robert L. Modlin, Benjamin G. Ferguson, Philip T. Liu, Kristina Edfeldt, Matthew Wheelwright
Publikováno v:
Nature medicine
Leprosy provides a model to investigate mechanisms of immune regulation in humans, given that the disease forms a spectrum of clinical presentations that correlate with host immune responses. Here we identified 13 miRNAs that were differentially expr
Autor:
Melissa Kanchanapoomi, Ulrich Zügel, Genhong Cheng, Mirjam Schenk, Robert L. Modlin, Andreas Steinmeyer, Xiaoran Zhang, Matthew Wheelwright, Philip T. Liu, Aria Vazirnia, Paul W. Dempsey, Valencia P. Walker, Bruce W. Hollis
Publikováno v:
Liu, Philip T; Schenk, Mirjam; Walker, Valencia P; Dempsey, Paul W; Kanchanapoomi, Melissa; Wheelwright, Matthew; Vazirnia, Aria; Zhang, Xiaoran; Steinmeyer, Andreas; Zügel, Ulrich; Hollis, Bruce W; Cheng, Genhong; Modlin, Robert L (2009). Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses. PLoS ONE, 4(6), e5810. Public Library of Science 10.1371/journal.pone.0005810
PLoS ONE
PloS one, vol 4, iss 6
PLoS ONE, Vol 4, Iss 6, p e5810 (2009)
PLoS ONE
PloS one, vol 4, iss 6
PLoS ONE, Vol 4, Iss 6, p e5810 (2009)
Antimicrobial effector mechanisms are central to the function of the innate immune response in host defense against microbial pathogens. In humans, activation of Toll-like receptor 2/1 (TLR2/1) on monocytes induces a vitamin D dependent antimicrobial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60b43ea362f30d13c7a16c845f77b3b
https://boris.unibe.ch/102306/1/19503839.PDF
https://boris.unibe.ch/102306/1/19503839.PDF
Autor:
Robert L. Modlin, Shinobu Suzuki, Gustavo A. Miranda, Sagar A. Vaidya, Genhong Cheng, Timothy F. Lane, Nobutaka Suzuki, Sean E. Doyle, Philip T. Liu, Wen Chen Yeh, Ryan M. O'Connell, Edward Kai-Hua Chow
Publikováno v:
The Journal of experimental medicine, vol 199, iss 1
The Journal of Experimental Medicine
The Journal of Experimental Medicine
Toll-like receptor (TLR) signaling and phagocytosis are hallmarks of macrophage-mediated innate immune responses to bacterial infection. However, the relationship between these two processes is not well established. Our data indicate that TLR ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea186269f9a3cbea8903faa0aa978f3
https://escholarship.org/uc/item/1v9026g1
https://escholarship.org/uc/item/1v9026g1
Autor:
H. Ray Jalian, Philip T. Liu, Jenny Kim, Annaliza J. Legaspi, Jenny Phan, Melissa Kanchanapoomi
Publikováno v:
Journal of Investigative Dermatology. (12):2777-2782
Propionibacterium acnes is a critical component in the pathogenesis of acne vulgaris, stimulating the production of various inflammatory mediators, such as cytokines and chemokines, important in the local inflammatory response found in acne. This stu