Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Natalie, S Ryan"'
Autor:
Carolin Koriath, Nick C. Fox, Sarah J. Tabrizi, Jonathan D. Rohrer, Natalie S. Ryan, Jonathan M. Schott, Simon Mead, Henry Houlden, Joanna Kenny
Publikováno v:
Nature Reviews Neurology. 17:23-36
Techniques for clinical genetic testing in dementia disorders have advanced rapidly but remain to be more widely implemented in practice. A positive genetic test offers a precise molecular diagnosis, can help members of an affected family to determin
Autor:
Amanda Heslegrave, Lucía Chávez-Gutiérrez, Josef Pannee, Helen Rice, Imogen Swift, Antoinette O'Connor, Jennifer M. Nicholas, Emily Abel, Nanet Willumsen, Henrik Zetterberg, Simon Mead, Selina Wray, Nick C. Fox, Charles Arber, Chris Frost, James M. Polke, Erik Portelius, Kaj Blennow, Philip S.J. Weston, Teresa Poole, Natalie S. Ryan
Publikováno v:
Brain
In vitro studies of autosomal dominant Alzheimer’s disease implicate longer amyloid-β peptides in disease pathogenesis; however, less is known about the behaviour of these mutations in vivo. In this cross-sectional cohort study, we used liquid chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb18fa743001979676e88b0dddc7cfea
https://lirias.kuleuven.be/handle/123456789/679509
https://lirias.kuleuven.be/handle/123456789/679509
Autor:
Timothy J. Shakespeare, Nick C. Fox, Keir Yong, Alexandra L. Young, Ross W. Paterson, Jason D. Warren, Amelia Carton, Aida Suarez-Gonzalez, Eulogio Gil-Néciga, Basil H. Ridha, Razvan V. Marinescu, Alexander J.M. Foulkes, Ivanna M. Pavisic, Daniel C. Alexander, Sebastien Ourselin, Elizabeth K. Warrington, Neil P. Oxtoby, Natalie S. Ryan, Dilek Ocal, Manja Lehmann, Nicholas C. Firth, Catherine F. Slattery, Marc Modat, Martin N. Rossor, Gil D. Rabinovici, Silvia Primativo, Bruce L. Miller, M. Jorge Cardoso, Jonathan M. Schott, Sebastian J. Crutch
Publikováno v:
Firth, N C, Primativo, S, Marinescu, R V, Shakespeare, T J, Suarez-Gonzalez, A, Lehmann, M, Carton, A, Ocal, D, Pavisic, I, Paterson, R W, Slattery, C F, Foulkes, A J M, Ridha, B H, Gil-Néciga, E, Oxtoby, N P, Young, A L, Modat, M, Cardoso, M J, Ourselin, S, Ryan, N S, Miller, B L, Rabinovici, G D, Warrington, E K, Rossor, M N, Fox, N C, Warren, J D, Alexander, D C, Schott, J M, Yong, K X X & Crutch, S J 2019, ' Longitudinal neuroanatomical and cognitive progression of posterior cortical atrophy ', Brain, vol. 142, no. 7, pp. 2082-2095 . https://doi.org/10.1093/brain/awz136
Digital.CSIC. Repositorio Institucional del CSIC
instname
Brain : a journal of neurology, vol 142, iss 7
Brain
Digital.CSIC. Repositorio Institucional del CSIC
instname
Brain : a journal of neurology, vol 142, iss 7
Brain
In the first multicentre, international longitudinal investigation of disease progression in posterior cortical atrophy, Firth et al. reveal distinct trajectories of cognitive decline and patterns of tissue loss compared to typical Alzheimer’s dise
Autor:
Dilek Ocal, Lynn Ramsey, Natalie S. Ryan, Charlie Murphy, Lu Brown, Keir Xx Yong, Brian L. Day, Pam Hulme, Gaynor Hulme, Amy Peters, Sebastian J. Crutch, Simon Ball, Isabel Phillips, A. D. Brown, Peter Riley, Aida Suarez Gonzalez, Charlie R Harrison, Anthony J. Woods, Diego Kaski
Publikováno v:
Dementia. 17:1011-1022
The current report describes the journey from the sharing of a single, extraordinary experience during a support group conversation to the development of a novel scientific investigation of balance problems in a rarer form of dementia. The story cent
Autor:
Argyro Alatza, Jackie M. Casey, John Hardy, Lachlan Harris, Caoimhe Kerins, Nick C. Fox, Henrik Zetterberg, Tammaryn Lashley, Selina Wray, Nanet Willumsen, Georgie Lines, Charles Arber, Natalie S. Ryan, Anika K. Mueller, Christopher Lovejoy
Publikováno v:
Cell Reports, Vol 34, Iss 2, Pp 108615-(2021)
Cell Reports
Cell Reports
Summary Mutations in presenilin 1 (PSEN1) or presenilin 2 (PSEN2), the catalytic subunit of γ-secretase, cause familial Alzheimer’s disease (fAD). We hypothesized that mutations in PSEN1 reduce Notch signaling and alter neurogenesis. Expression da
Autor:
Ivanna M. Pavisic, Jessica D. Collins, Sebastian J. Crutch, Daniel C. Alexander, Kirsty Lu, Neil P. Oxtoby, Nick C. Fox, Antoinette O'Connor, Philip S.J. Weston, Natalie S. Ryan
Publikováno v:
Alzheimer's Research & Therapy
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-9 (2020)
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-9 (2020)
Background Understanding the earliest manifestations of Alzheimer’s disease (AD) is key to realising disease-modifying treatments. Advances in neuroimaging and fluid biomarkers have improved our ability to identify AD pathology in vivo. The critica
Autor:
Nick C. Fox, Marc Modat, Hui Zhang, Jonathan M. Schott, Jennifer M. Nicholas, Yuying Liang, Martin N. Rossor, Nicolas Toussaint, Sebastien Ourselin, Teresa Poole, Natalie S. Ryan, Philip S.J. Weston, Ivor J. A. Simpson
Publikováno v:
Alzheimer's Research & Therapy
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-10 (2020)
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-10 (2020)
Background There is increasing interest in improving understanding of the timing and nature of early neurodegeneration in Alzheimer’s disease (AD) and developing methods to measure this in vivo. Autosomal dominant familial Alzheimer’s disease (FA
Autor:
Chris Frost, Imogen Swift, Juan Lantero Rodriguez, Martin N. Rossor, Nicholas J. Ashton, Ivanna M. Pavisic, Henrik Zetterberg, Teresa Poole, Natalie S. Ryan, Amanda Heslegrave, Simon Mead, Kaj Blennow, Nick C. Fox, James M. Polke, Elisha Chung, Emily Abel, Philip S.J. Weston, Suzie Barker, Ayesha Khatun, Antoinette O'Connor, Thomas K. Karikari
Publikováno v:
Mol Psychiatry
Blood biomarkers have great potential to advance clinical care and accelerate trials in Alzheimer’s disease (AD). Plasma phospho-tau181 (p-tau181) is a promising blood biomarker however, it is unknown if levels increase in presymptomatic AD. Theref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68fe0e9d09a8f66af16cf96d8dc35a31
https://europepmc.org/articles/PMC7612227/
https://europepmc.org/articles/PMC7612227/
Autor:
Adni Investigators, Tammaryn Lashley, Josephine Barnes, Cassidy M. Fiford, Natalie S. Ryan, Carole H. Sudre, Chris Frost, Phoebe Walsh
This study investigated the relationship between white matter hyperintensities (WMH) and cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers. Subjects included 180 controls, 107 individuals with a significant memory concern, 320 individuals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97061fd799f3643bef5e5e457bca1ac3
https://researchonline.lshtm.ac.uk/id/eprint/4657622/1/Walsh-etal-2020-CSF_amyloid_is_a_consistent_predictor.pdf
https://researchonline.lshtm.ac.uk/id/eprint/4657622/1/Walsh-etal-2020-CSF_amyloid_is_a_consistent_predictor.pdf
Autor:
Tammaryn Lashley, Chris Frost, Natalie S. Ryan, Carole H. Sudre, Adni Investigators, Phoebe Walsh, Cassidy M. Fiford, Josephine Barnes
Publikováno v:
Neurobiology of aging. 97
Neurofilament light (NFL) is an emerging marker of axonal degeneration. This study investigated the relationship between white matter hyperintensities (WMHs) and plasma NFL in a large elderly cohort with, and without, cognitive impairment. We used th