Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Maria Tsoli"'
Autor:
Jinhan Xie, Paulette Barahona, Michelle Haber, Emily Mould, Andrew J. Gifford, Loretta Lau, Amit Kumar, Timothy W. Failes, Marie Wong-Erasmus, Dylan Grebert-Wade, Greg M. Arndt, M. Emmy M. Dolman, Dong-Anh Khuong-Quang, Chelsea Mayoh, Kanika Bhatia, Shu-Oi Chow, Alvin Kamili, Roxanne Cadiz, Richard B. Lock, Maria Tsoli, Vanessa Tyrrell, David S. Ziegler, Glenn M. Marshall, Penny Athanasatos
Publikováno v:
Cancer Cytopathology. 129:805-818
Background The development of high-throughput drug screening (HTS) using primary cultures provides a promising, clinically translatable approach to tailoring treatment strategies for patients with cancer. However, this has been challenging for solid
Autor:
Michael Karremann, Olaf Witt, Tabitha Bloom, Winand N.M. Dinjens, Felipe Andreiuolo, Michael Farrell, Scott Newman, Simone Hettmer, James Dalton, Leslie R. Bridges, Jens Schittenhelm, Martin Ebinger, Thomas S. Jacques, Francesca Diomedi-Camassei, Dominik Sturm, Jane Chalker, Matija Snuderl, David W. Ellison, Paula Proszek, Irene Slavc, Matthias A. Karajannis, Giovanna Stefania Colafati, Louise Howell, Christine Haberler, Simon Bailey, Barbara C. Worst, David A. Solomon, Andrew J. Martin, Stefan M. Pfister, Maria Vinci, Ho Keung Ng, Kelly Haupfear, Mellissa Maybury, Stephen Gilheeney, Bassel Zebian, Martin Sill, David T.W. Jones, Pablo Hernáiz Driever, Martin U. Schuhmann, Angela Mastronuzzi, Jessica K.R. Boult, Matthew Clarke, Rachael Natrajan, Kornelius Kerl, Lawrence Doey, Alex Virasami, Andrey Korshunov, Christof M. Kramm, Jane Cryan, David E. Kram, Timothy E.G. Hassall, Debbie Hughes, Claire Mitchell, Chris Jones, Monika A. Davare, Evelina Miele, Safa Al-Sarraj, Sara Temelso, Catherine Rowe, Suzanne J. Baker, Sergey Popov, Torsten Pietsch, Matthew D. Wood, Roger J. Packer, Lynley V. Marshall, Michael Capra, Valeria Molinari, Diana Carvalho, Marc Zuckermann, Andreas von Deimling, Uwe Kordes, Kathreena M Kurian, Shani Caspi, Ira J. Dunkel, Wilda Orisme, Ulrich Schüller, Claire Cairns, Matthias Preusser, Kristian Aquilina, Petter Brandal, Stephen Lowis, Iris Stoler, Christopher Chandler, Lissa C. Baird, Marc K. Rosenblum, Ji Wen, Felix Sahm, Barbara Faganel Kotnik, Stephen Crosier, Mara Popović, Andrea Carai, Lotte Hiddingh, Thale Kristin Olsen, Fernando Carceller, Simon P. Robinson, Maria Tsoli, Ruth G. Tatevossian, Anna Burford, Mike Hubank, Elisa Izquierdo, Tejus Bale, David Capper, Andrew S. Moore, David S. Ziegler, Amy R Fairchild, Aimee Avery, Alan Mackay, Jessica C Pickles, Mark Kristiansen, Jeffrey Knipstein, Darren Hargrave, Mark J. Cowley, Tobey J. MacDonald, Britta Ismer
Publikováno v:
Cancer Discovery, 10(7), 942-963. American Association for Cancer Research Inc.
Clarke, M, Mackay, A, Ismer, B, Pickles, J C, Tatevossian, R G, Newman, S, Bale, T A, Stoler, I, Izquierdo, E, Temelso, S, Carvalho, D M, Molinari, V, Burford, A, Howell, L, Virasami, A, Fairchild, A R, Avery, A, Chalker, J, Kristiansen, M, Haupfear, K, Dalton, J D, Orisme, W, Wen, J, Hubank, M, Kurian, K M, Rowe, C & Lowis, S P 2020, ' Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes ', Cancer Discovery . https://doi.org/10.1158/2159-8290.CD-19-1030
Cancer Discov
Clarke, M, Mackay, A, Ismer, B, Pickles, J C, Tatevossian, R G, Newman, S, Bale, T A, Stoler, I, Izquierdo, E, Temelso, S, Carvalho, D M, Molinari, V, Burford, A, Howell, L, Virasami, A, Fairchild, A R, Avery, A, Chalker, J, Kristiansen, M, Haupfear, K, Dalton, J D, Orisme, W, Wen, J, Hubank, M, Kurian, K M, Rowe, C & Lowis, S P 2020, ' Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes ', Cancer Discovery . https://doi.org/10.1158/2159-8290.CD-19-1030
Cancer Discov
Infant high-grade gliomas appear clinically distinct from their counterparts in older children, indicating that histopathologic grading may not accurately reflect the biology of these tumors. We have collected 241 cases under 4 years of age, and carr
Autor:
Meera Warby, Gang Wu, David G. Huntsman, Maria Tsoli, Georgia Chenevix-Trench, Charles G. Mullighan, Kenneth Offit, Evadnie Rampersaud, Vasiliki Leventaki, Katherine L. Tucker, Ilaria Iacobucci, Kasmintan A. Schrader, Debbie Payne-Turner, Vijai Joseph, David S. Ziegler, Michelle L. Churchman, Rosemary Sutton, Chunxu Qu, R. Scott Mead
Publikováno v:
Blood Advances. 3:1039-1046
Recent studies have identified germline mutations in TP53, PAX5, ETV6, and IKZF1 in kindreds with familial acute lymphoblastic leukemia (ALL), but the genetic basis of ALL in many kindreds is unknown despite mutational analysis of the exome. Here, we
Autor:
John Caird, Stephanie Francis, Rachid Drissi, Chris Jones, Anahid Ehteda, Maria Vinci, Cynthia Hawkins, Jordan R. Hansford, Darach Crimmins, Alexander Plessier, Dannis G. van Vuurden, Tim Hassall, Danielle Upton, Bing Liu, David Castel, Jane Pears, Jane Cryan, Michael Farrell, Louise E. Ludlow, Esther Hulleman, Diana Carvalho, Michelle Monje, Chelsea Mayoh, Michaël H. Meel, Maria Tsoli, Jacques Grill, Andrea Carai, Maryam Fouladi, Maria Kirby, David S. Ziegler, Angela Mastronuzzi, Nicholas G. Gottardo, Han Shen, Laura Franshaw
Publikováno v:
Tsoli, M, Shen, H, Mayoh, C, Franshaw, L, Ehteda, A, Upton, D, Carvalho, D, Vinci, M, Meel, M H, van Vuurden, D, Plessier, A, Castel, D, Drissi, R, Farrell, M, Cryan, J, Crimmins, D, Caird, J, Pears, J, Francis, S, Ludlow, L E A, Carai, A, Mastronuzzi, A, Liu, B, Hansford, J, Gottardo, N, Hassall, T, Kirby, M, Fouladi, M, Hawkins, C, Monje, M, Grill, J, Jones, C, Hulleman, E & Ziegler, D S 2019, ' International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma ', Journal of Neuro-Oncology, vol. 141, no. 2, pp. 253-263 . https://doi.org/10.1007/s11060-018-03038-2
Journal of Neuro-Oncology, 141(2), 253-263. Kluwer Academic Publishers
Journal of Neuro-Oncology, 141(2), 253-263. Kluwer Academic Publishers
Purpose: Diffuse intrinsic pontine glioma is the most aggressive form of high grade glioma in children with no effective therapies. There have been no improvements in survival in part due poor understanding of underlying biology, and lack of represen
Autor:
Loretta Lau, Mark J. Cowley, Paul G Ekert, Michael Rodriguez, Chelsea Mayoh, Richard J. Cohn, Velimir Gayevskiy, Marie Wong, Andrew J. Gifford, Mark Pinese, Amit Kumar, Mark Reynolds, Michelle Haber, David S. Ziegler, Vanessa Tyrrell, Michael C. Cox, Glenn M. Marshall, Dong-Anh Khuong-Quang, Emily Mould, Maria Tsoli
Publikováno v:
British Journal of Cancer
Genes encoding TRK are oncogenic drivers in multiple tumour types including infantile fibrosarcoma, papillary thyroid cancer and high-grade gliomas (HGG). TRK fusions have a critical role in tumourigenesis in 40% of infant HGG. Here we report the fir
Autor:
Chelsea Mayoh, Mark R. Burns, Ruby Pandher, Anahid Ehteda, Michelle Haber, Laura D. Gamble, David S. Ziegler, Caitlin Ung, Dannielle Upton, Nada Jabado, Claudia L. Kleinman, Maria Tsoli, Steven Hébert, Denise M. T. Yu, Murray D. Norris, Aaminah Khan
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Diffuse intrinsic pontine glioma (DIPG) is an incurable malignant childhood brain tumor, with no active systemic therapies and a 5-year survival of less than 1%. Polyamines are small organic polycations that are essential for DNA replication, transla
Autor:
Swapna Joshi, Murray D. Norris, Sandy Simon, Orazio Vittorio, Sylvie Shen, Andrei V. Gudkov, Ornella Tolhurst, Anahid Ehteda, Caitlin Ung, Jourdin R. C. Rouaen, Ruby Pandher, Aaminah Khan, Michelle Haber, Elisha Hayden, Laura Franshaw, Rebecca Lehmann, Chelsea Mayoh, Yujie Tang, Katerina Gurova, David S. Ziegler, Maria Tsoli, Federico M. Giorgi, Anjana Gopalakrishnan, Jie Liu, Chi Nam Ignatius Pang, Anne Kankean, Peter Trebilcock
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108994-(2021)
Summary: Diffuse intrinsic pontine glioma (DIPG) is an aggressive and incurable childhood brain tumor for which new treatments are needed. CBL0137 is an anti-cancer compound developed from quinacrine that targets facilitates chromatin transcription (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbee79680e90f0fba780fc68415fa1d
https://hdl.handle.net/11585/831846
https://hdl.handle.net/11585/831846
Autor:
Anahid Ehteda, Greg M. Arndt, Annafranca Farfalla, Domenico Cassano, Valerio Voliani, Caitlin Ung, Maria Tsoli, Jie Liu, Giuseppe Cirillo, Timothy W. Failes, Dannielle Upton, Salvador Pocoví-Martínez, Maria Kavallaris, David S. Ziegler, Friederike M. Mansfeld, Orazio Vittorio, Christopher J. Katsinas
Publikováno v:
Cancers, Vol 13, Iss 1278, p 1278 (2021)
Cancers
Volume 13
Issue 6
Cancers
Volume 13
Issue 6
Simple Summary Diffuse intrinsic pontine gliomas (DIPGs) are the most aggressive high-grade gliomas known to affect children. Due to the infiltrative nature of the DIPG tumours in the brainstem, they are very difficult to treat. Unfortunately, childr
Autor:
Glenn M. Marshall, Murray D. Norris, Jennifer A. Byrne, Maria Tsoli, David S. Ziegler, Chelsea Mayoh, Siva Sivarajasingam, Laura Franshaw
BACKGROUND. There are limited data to predict which novel childhood cancer therapies are likely to be successful. To help rectify this, we sought to identify the factors that impact the success of phase II clinical trials for pediatric malignancies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4584d16e5d5311aa4798ad5c74adaed
https://europepmc.org/articles/PMC6693728/
https://europepmc.org/articles/PMC6693728/
Autor:
Jie Liu, Richard J. Cohn, Julia X. Yin, Andrew J. Gifford, Michael Rodriguez, Martin A. Weber, Warren Kaplan, Laura Franshaw, Federica Saletta, Swapna Joshi, Tim Failes, Kerrie L. McDonald, Glenn M. Marshall, Carol Wadham, Mark J. Cowley, Emily Mould, Paul G Ekert, Greg M. Arndt, Vanessa Tyrrell, Velimir Gayevskiy, Mark Pinese, Amit Kumar, David S. Ziegler, Toby Trahair, Maria Tsoli, Michelle Haber
Publikováno v:
Cancer Biology & Therapy
Pediatric high grade gliomas (HGG) are primary brain malignancies that result in significant morbidity and mortality. One of the challenges in their treatment is inter- and intra-tumoral heterogeneity. Precision medicine approaches have the potential