Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kristin Wilson"'
Autor:
Johannes Dworzak, Daniel G. Rudmann, Famke Aeffner, Kristin Wilson, Crystal Faelan, Suzanne Kanaly, Manish Ranjitkar, Holger Lange, J Kris Piper, Steven A. Moore, Joshua C. Black, Anthony J. Milici, D. Frank, Jay S. Charleston, G. David Young, Alexander Moody
Publikováno v:
Archives of Pathology & Laboratory Medicine. 143:197-205
Context.—Duchenne muscular dystrophy is a rare, progressive, and fatal neuromuscular disease caused by dystrophin protein loss. Common investigational treatment approaches aim at increasing dystrophin expression in diseased muscle. Some clinical tr
The Gold Standard Paradox in Digital Image Analysis: Manual Versus Automated Scoring as Ground Truth
Autor:
Famke Aeffner, Cris L. Luengo Hendriks, G. Dave Young, Joshua C. Black, Brad Bolon, Nathan T. Martin, Daniel G. Rudmann, Kristin Wilson, Joseph S. Krueger, Roberto Gianani, Sally R. Koegler
Publikováno v:
Archives of Pathology & Laboratory Medicine. 141:1267-1275
Context.—Novel therapeutics often target complex cellular mechanisms. Increasingly, quantitative methods like digital tissue image analysis (tIA) are required to evaluate correspondingly complex biomarkers to elucidate subtle phenotypes that can in
Publikováno v:
Toxicologic pathology. 48(1)
Pain is a complex constellation of cognitive, unpleasant sensory, and emotional experiences that primarily serves as a survival mechanism. Pain arises in the peripheral nervous system and pain signals synapse with nerve tracts extending into the cent
Autor:
John N. Hutchinson, Tyler Laszewski, Jessalyn M. Ubellacker, Victor Barrera, Rachel A. Freedman, Kristin Wilson, Sara Morrow, Elizabeth A. Mittendorf, Molly J. DeCristo, Jaclyn Sceneay, Daniel G. Stover, Sandra S. McAllister, Yuanbo Qin, Gregory J. Goreczny
Publikováno v:
Cancer discovery. 9(9)
Immune checkpoint blockade (ICB) therapy, which targets T cell–inhibitory receptors, has revolutionized cancer treatment. Among the breast cancer subtypes, evaluation of ICB has been of greatest interest in triple-negative breast cancer (TNBC) due
Autor:
Oliver C. Turner, Erik Hagendorn, Dirk Schaudien, Hibret A. Adissu, Famke Aeffner, Susan Newbigging, Robert Klopfleisch, Robert D. Cardiff, Michael C. Boyle, Mark J. Hoenerhoff, Kristin Wilson
Advancements in technology and digitization have ushered in novel ways of enhancing tissue-based research via digital microscopy and image analysis. Whole slide imaging scanners enable digitization of histology slides to be stored in virtual slide re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddf17482e7060326ca692016396317b
https://publica.fraunhofer.de/handle/publica/259052
https://publica.fraunhofer.de/handle/publica/259052
Autor:
Jay S. Charleston, G. David Young, Kristin Wilson, Daniel G. Rudmann, Jon Tinsley, Crystal Faelan, Steven A. Moore, Anthony J. Milici, D. Frank, Janet C. Patterson-Kane
Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are neuromuscular disorders that primarily affect boys due to an X-linked mutation in the DMD gene, resulting in reduced to near absence of dystrophin or expression of truncated fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd011661252ff27fbe18cfc203f5f1e
https://europepmc.org/articles/PMC5788182/
https://europepmc.org/articles/PMC5788182/
Autor:
Famke Aeffner, Dan Rudmann, Brad Bolon, Kristin Wilson, Charles R. Mahrt, Suzanne Kanaly, G. David Young, Elaine Charles
Publikováno v:
Toxicologic pathology. 44(6)
Historically, pathologists perform manual evaluation of H&E- or immunohistochemically-stained slides, which can be subjective, inconsistent, and, at best, semiquantitative. As the complexity of staining and demand for increased precision of manual ev