Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Joshua Keegan"'
Autor:
Joshua Keegan, Goro Tajima, Anupamaa J Seshadri, Laura A Cahill, Kazuma Yamakawa, Yasutaka Nakahori, Fei Guo, James A. Lederer
Publikováno v:
J Leukoc Biol
CD4+ regulatory T cells (Tregs) are acutely activated by traumatic injury, which suggests that they may react to injury with similar kinetics as memory T cells. Here, we used a mouse burn trauma model to screen for memory-like T cell responses to inj
Autor:
Shahzad Shaefi, Simon C. Robson, Leo E. Otterbein, Michael B. Yaffe, Anupamaa J Seshadri, James A. Lederer, Carl J. Hauser, Fei Guo, Fan Zhang, Jennifer P Nguyen, Laura A Cahill, Joshua Keegan
Publikováno v:
PMC
Injury
Injury
Background Trauma causes tissue injury that results in the release of damage associated molecular patterns (DAMPs) and other mediators at the site of injury and systemically. Such mediators disrupt immune system homeostasis and may activate multicell
Autor:
Anna Karpenko, Joshua Keegan
Publikováno v:
Emergency medicine clinics of North America. 39(1)
The differential diagnosis for the comatose patient is includes structural abnormality, seizure, encephalitis, metabolic derangements, and toxicologic etiologies. Identifying and treating the underlying pathology in a timely manner is critical for th
Autor:
Joshua Keegan, D. Gallo, Jennifer P Nguyen, Dusan Hanidziar, Leo E. Otterbein, James A. Lederer, Yasutaka Nakahori, Laura A Cahill, Simon C. Robson
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Prolonged exposure to hyperoxia has deleterious effects on the lung, provoking both inflammation and alveolar injury. The elements of hyperoxic injury, which result in high rates of lethality in experimental models, are thought to include multicellul
Autor:
Gabriel A. Brat, Anupamaa Seshadri, Yasutaka Nakahori, Takeshi Wada, Ali Salim, Carl J. Hauser, Reza Askari, Jennifer P Nguyen, Matt Giangola, Joshua Keegan, Brian K. Yorkgitis, Wei Li, James A. Lederer
Publikováno v:
The journal of trauma and acute care surgery. 87(2)
Trauma induces a complex immune response, requiring a systems biology approach to capture multicellular changes. Using mass cytometry by time-of-flight (CyTOF), we evaluated time-dependent changes in peripheral blood in trauma patients to identify ch
Autor:
Alexandra V. Bocharnikov, Jennifer H. Anolik, Peter A. Nigrovic, James A. Lederer, Joshua Keegan, Chamith Y Fonseka, Michael B. Brenner, Soumya Raychaudhuri, Betty Diamond, Deepak A. Rao
Publikováno v:
Adaptive Immunity.
Background Pathologic T cell-B cell interactions and production of autoantibodies are hallmark features of SLE. T follicular helper (Tfh) cells are generally considered the principal T cell population capable of helping B cells. However, distinct T c
Autor:
Anupamaa J Seshadri, Ali Salim, Reza Askari, Gabriel A. Brat, James W. Dolan, James A. Lederer, Joshua Keegan, Brian K. Yorkgitis
Publikováno v:
Critical care medicine. 45(9)
Trauma induces a complex immune response that requires a systems biology research approach. Here, we used a novel technology, mass cytometry by time-of-flight, to comprehensively characterize the multicellular response to trauma.Peripheral blood mono
Publikováno v:
Journal of leukocyte biology. 99(3)
T cell receptor γδ cells are known to be the primary effector T cells involved in the response to bacterial infections, yet their phenotypic characteristics are not as well established as other T cell subsets. In this study, we used cytometry by ti