Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Giulia Scalisi"'
Autor:
Carolina Manganeli Polonio, Evelyn S. Heck, Zhaorong Li, Francisco J. Quintana, Michael A. Wheeler, Cristina Gutiérrez-Vázquez, Moneera Alsuwailm, Isaac M. Chiu, Katelyn V. Batterman, Giulia Scalisi, Douglas L. Rosene, Alexandre Prat, Felipe A. Pinho-Ribeiro, Liliana Maria Sanmarco, Burkhard Becher, Mathias Linnerbauer, Federico Giovannoni, Stephanie Zandee
Publikováno v:
Nature. 590:473-479
Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that have important homeostatic and disease-promoting functions1. However, little is known about the homeostatic anti-inflammatory activities of astrocytes and their
Autor:
Kevin Petrecca, Alexandre Prat, John A. Heyman, Burkhard Becher, Jack P. Antel, Zhaorong Li, Michael A. Wheeler, Giulia Scalisi, Assaf Rotem, Charles P. Couturier, Liliana Maria Sanmarco, Iain C. Clark, Jeffrey R. Moffitt, Shravan Thaploo, Francisco J. Quintana, Stephanie Zandee, David A. Weitz, Veit Rothhammer, Jiannis Ragoussis, Sarah Alkwai, Brianna R. Watson, Emily C. Tjon
Publikováno v:
Nature, vol 578, iss 7796
Nature
Nature
Multiple sclerosis is a chronic inflammatory disease of the CNS(1). Astrocytes contribute to the pathogenesis of multiple sclerosis(2), but little is known about the heterogeneity of astrocytes and its regulation. Here we report the analysis of astro
Autor:
Francesca Fallarino, Ursula Grohmann, Giada Mondanelli, Marco Gargaro, Giorgia Manni, Giulia Scalisi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 757, p 757 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
The aryl-hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates numerous cellular responses. Originally investigated in toxicology because of its ability to bind environmental contaminants, AhR has attracted enormous atte
Autor:
Marco Gargaro, Eleonora Padiglioni, Giorgia Manni, Giulia Scalisi, Giada Mondanelli, Rita Romani, Francesca Fallarino, Maria Teresa Pallotta, Dario Nardi, Vincenzo Nicola Talesa, Paolo Puccetti
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
Endotoxin tolerance aims at opposing hyperinflammatory responses to lipopolysaccharide (LPS) exposure. The aryl hydrocarbon receptor (AhR) participates in protection against LPS-mediated tissue damage, as it plays a necessary role in restraining the
Autor:
Maria Teresa Pallotta, Ciriana Orabona, Marco Gargaro, Elisa Proietti, Eleonora Panfili, Ioana Maria Iamandii, Emilia Maria Cristina Mazza, Giorgia Manni, Violetta Cecchetti, Maria Laura Belladonna, Carmine Vacca, Serena Massari, Ursula Grohmann, Silvio Bicciato, Oriana Tabarrini, Davide Matino, Roberta Bianchi, Paolo Puccetti, Francesca Fallarino, Alberta Iacono, Giulia Scalisi, Claudia Volpi, Giada Mondanelli
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology, Vol 10 (2019)
Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the first step in the kynurenine pathway of tryptophan (Trp) degradation that produces several biologically active Trp metabolites. L-kynurenine (Kyn), the first byproduct by IDO1, promotes immunoregulat
Autor:
Alexandre Prat, Russ Hauser, Francisco J. Quintana, Manon Blain, Stephanie Zandee, Giulia Scalisi, Jessica E. Kenison, Merja Jaronen, Cristina Gutiérrez-Vázquez, Andreia Barroso, Michael A. Wheeler, Ruxandra Covacu, Jack P. Antel, Vijayaraghava T.S. Rao, Emily C. Tjon, Patrick Hewson, Veit Rothhammer, Chun-Cheih Chao
Publikováno v:
Cell. 176(3)
Genome-wide studies have identified genetic variants linked to neurologic diseases. Environmental factors also play important roles, but no methods are available for their comprehensive investigation. We developed an approach that combines genomic da
Autor:
Abdolmohamad Rostami, Carmine Vacca, Rita Romani, Marco Gargaro, James Crooks, Antonella Turco, Francesca Fallarino, Davide Matino, Bruno Gran, Paolo Puccetti, Matteo Pirro, Giulia Scalisi, Claudia Volpi
Publikováno v:
Mediators of Inflammation, Vol 2017 (2017)
Mediators of Inflammation
Mediators of Inflammation
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory, demyelinating disease of the CNS that mimics human multiple sclerosis (MS), and it is thought to be driven by Th1 and Th17 myelin-reactive cells. Although adaptive immunity is clearl