Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Daniel D. De Carvalho"'
Publikováno v:
Cancer Discovery. 11:2707-2725
Features of the cancer epigenome distinguish cancers from their respective cell of origin and establish therapeutic vulnerabilities that can be exploited through pharmacologic inhibition of DNA- or histone-modifying enzymes. Epigenetic therapies conv
Autor:
Thomas Kislinger, Jeffrey Zuccato, Shahbaz Khan, Yasin Mamatjan, Sébastien Froelich, Gelareh Zadeh, Namita Sinha, Shirin Karimi, Olivia Singh, Jeffrey C Liu, Ankur Chakravarthy, Anne-Laure Bernat, Joao Paulo Almeida, Homa Adle-Biassette, Farshad Nassiri, Sheila Mansouri, Vikas Patil, Kenneth Aldape, Mohammed Hasen, Daniel D. De Carvalho
Publikováno v:
Neuro Oncol
Background Chordomas are rare malignant bone cancers of the skull-base and spine. Patient survival is variable and not reliably predicted using clinical factors or molecular features. This study identifies prognostic epigenetic chordoma subtypes that
Autor:
Shengrui Feng, Daniel D. De Carvalho
Publikováno v:
The FEBS Journal. 289:1214-1239
The appropriate coordination between epigenetic regulators is essential for spatial and temporal regulation of gene expression and maintenance of cell identity. Cancer is a disease driven by both genetic and epigenetic alterations. The widespread dys
Autor:
Joe McDonough, G. Lesa, Franca Ligas, Miguel Rivera, Ira Jacobs, Andrew D.J. Pearson, Malcolm A. Smith, Maureen Hattersley, Dominik Karres, Aundrietta D. Duncan, Nada Jabado, Daniel D. De Carvalho, Koen Norga, Peter C. Adamson, Donna Ludwinski, Gregory H. Reaman, Brian Gadbaw, Elizabeth Fox, Samuel C. Blackman, Mark W. Kieran, Gilles Vassal, Christian Baumann, Vickie Buenger, Delphine Heenen, Scott A. Armstrong, Michael J. Kelly, Amy Barone, Adrian Senderowicz, Franck Bourdeaut, Martha Donoghue, Tilmann Taube, Peter T.C. Ho, Lynley V. Marshall, Patrick A. Brown, Michael L. Meyers, Kimberly Stegmaier, Zariana Nikolova, Susan L. Weiner
Publikováno v:
European Journal of Cancer. 139:135-148
The fifth multistakeholder Paediatric Strategy Forum focussed on epigenetic modifier therapies for children and adolescents with cancer. As most mutations in paediatric malignancies influence chromatin-associated proteins or transcription and paediat
Autor:
Helen Loo Yau, Parinaz Mehdipour, Ilias Ettayebi, Charles A. Ishak, Ankur Chakravarthy, Daniel D. De Carvalho, Catherine A. O’Brien, Amir H. Hosseini, Fabíola Attié de Castro, Yadong Wang, Sagi Abelson, Sajid A. Marhon
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Cancer therapies that target epigenetic repressors can mediate their effects by activating retroelements within the human genome. Retroelement transcripts can form double-stranded RNA (dsRNA) that activates the MDA5 pattern recognition receptor1–6.
Autor:
Wail Ba-alawi, Evelyne Lima-Fernandes, Jason W. Locasale, Daniel D. De Carvalho, Paul Savage, Ilias Ettayebi, Hellen Kuasne, Morag Park, Felicia Tai, Yunchi Ingrid Kao, Benjamin Haibe-Kains, Alexandra N. Fedor, Paul Guilhamon, Giacomo Grillo, Seyed Ali Madani Tonekaboni, Cheryl H. Arrowsmith, Xiaojing Liu, Constanza Martinez, Anne-Marie Fortier, Mathieu Lupien, Alex Murison, Geneviève Deblois, David W. Cescon
Publikováno v:
Cancer Discovery. 10:1312-1329
Tumor progression upon treatment arises from preexisting resistant cancer cells and/or adaptation of persister cancer cells committing to an expansion phase. Here, we show that evasion from viral mimicry response allows the growth of taxane-resistant
Autor:
Karan J. Abraham, Miling Wang, Jack Greenblatt, Lauren A. Ostrowski, Aparna Gorthi, Parasvi S. Patel, Daniel D. De Carvalho, Razq Hakem, Michael Ohh, Roxanne Oshidari, Alexander J.R. Bishop, Violena Pietrobon, Anas Samman, Arash Algouneh, Dorothy Yanling Zhao, Stephen Lee, Michael Bokros, Janet N.Y. Chan, V Talya Yerlici, Rajat Singhania, Brendan C. Dickson, Yupeng Liu, Elva Vidya, Negin Khosraviani, Karim Mekhail
Publikováno v:
Nature
Proteins are manufactured by ribosomes—macromolecular complexes of protein and RNA molecules that are assembled within major nuclear compartments called nucleoli1,2. Existing models suggest that RNA polymerases I and III (Pol I and Pol III) are the
Publikováno v:
Annual Review of Cancer Biology. 4:159-176
Domesticated retroelements contribute extensively as regulatory elements within host gene networks. Upon germline integration, retroelement mobilization is restricted through epigenetic silencing, mutational degradation, and innate immune defenses de
Publikováno v:
Nature Protocols. 14:2749-2780
Circulating cell-free DNA (cfDNA) comprises small DNA fragments derived from normal and tumor tissue that are released into the bloodstream. Recently, methylation profiling of cfDNA as a liquid biopsy tool has been gaining prominence due to the prese
Publikováno v:
Immunity. 54:11-13
In a recent issue of Cell, Bowling et al. describe a mechanism by which spliceosome-targeted therapies result in intron-containing transcripts that form double-stranded RNAs (dsRNAs), thereby activating tumor antiviral signaling (viral mimicry) and d