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pro vyhledávání: '"Christopher Randolph"'
Autor:
Christopher Randolph
Publikováno v:
The American Journal of Geriatric Psychiatry. 27:1428-1432
Correctly diagnosing early symptomatic Alzheimer disease in the context of multinational clinical trials poses a significant challenge. Subjective complaints of memory are fairly ubiquitous in an older population, and establishing the presence of def
Autor:
Anna-Karin Berger, David Miller, Chris J. Edgar, Christopher Randolph, Ananth Annapragada, Michael Gold, Lisa J. Bain, Christopher J. Weber, Dominic Trépel, David S. Knopman, Glen Wunderlich, J. Michael Ryan, Alette M. Wessels, Dorene M. Rentz, Maria C. Carrillo, Megan Canniere Zoschg, Adam M. Staffaroni
Publikováno v:
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 7, Iss 1, Pp n/a-n/a (2021)
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 7, Iss 1, Pp n/a-n/a (2021)
Demonstrating that treatments are clinically meaningful across the Alzheimer's disease (AD) continuum is critical for meeting our goals of accelerating a cure by 2025. While this topic has been a focus of several Alzheimer's Association Research Roun
Autor:
David Miller, H. Robert Brashear, Christopher J. Weber, Christopher Randolph, Eric McDade, Paul Maruff, Lisa J. Bain, Martin M. Bednar, Zahinoor Ismail, Maria C. Carrillo, Ann Marie Hake
Publikováno v:
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Alzheimer's disease (AD) is a continuum consisting of a preclinical stage that occurs decades before symptoms appear. As researchers make advances in investigating the continuum, the importance of developing drugs for secondary prevention is garnerin
Autor:
Christopher Randolph, Joann Blessing-Moore, Kathleen Dass, Mark Rubin, Stuart Z. Epstein, Andrew Cooke, Andy Nish, Anil Nanda, Karen L. Gregory, Kirk V. Shepard, Miguel Capão-Filipe, Anita N. Wasan, Justin Greiwe
Publikováno v:
The journal of allergy and clinical immunology. In practice. 8(8)
Exercise-induced bronchoconstriction, otherwise known as exercise-induced bronchoconstriction with asthma or without asthma, is an acute airway narrowing that occurs as a result of exercise and can occur in patients with asthma. A panel of members fr
Autor:
David Michelson, Robert S. Stern, Christopher Randolph, Paul S. Aisen, Craig Shering, Nicole Dupre, Alette M. Wessels, Christopher Lines, James Kost, Bruno Vellas, Lyn Harper Mozley, Pierre N. Tariot, Tiffini Voss, Michael F. Egan, Christine Furtek, Yuki Mukai, John R. Sims, Jeffrey L. Cummings, Scott W. Andersen
Publikováno v:
Alzheimer'sdementia : the journal of the Alzheimer's AssociationREFERENCES. 16(11)
Introduction The APECS and AMARANTH trials showed that beta-secretase (BACE) inhibitors verubecestat and lanabecestat failed to slow cognitive and functional decline in individuals with prodromal or early Alzheimer's disease. Here, the performance on
Autor:
Christopher Randolph
Publikováno v:
J Neurol Neurosurg Psychiatry
OBJECTIVE: To determine whether subjects with chronic traumatic encephalopathy (CTE) and dementia have distinct clinical features compared to subjects with pathologically confirmed Alzheimer’s disease (AD). METHODS: Among 339 subjects assessed for
Autor:
Terry E. Goldberg, David S. Knopman, Robert Brashear, Maria C. Carrillo, Marta Segardahl Storck, Sarah E Tomaszewski Farias, Kathleen A. Welsh-Bohmer, Sandra Weintraub, James Hendrix, Michael T. Ropacki, Ferenc Martenyi, Lisa J. Bain, Judith Jaeger, Sietske A.M. Sikkes, Jessica B. Langbaum, Christopher Randolph, Denise C. Park, Ana Graf, Kumar Budur
Publikováno v:
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Alzheimer's and Dementia: Translational Research and Clinical Interventions, 4, 64-75. Elsevier Inc.
Weintraub, S, Carrillo, M C, Farias, S T, Goldberg, T E, Hendrix, J A, Jaeger, J, Knopman, D S, Langbaum, J B, Park, D C, Ropacki, M T, Sikkes, S A M, Welsh-Bohmer, K A, Bain, L J, Brashear, R, Budur, K, Graf, A, Martenyi, F, Storck, M S & Randolph, C 2018, ' Measuring cognition and function in the preclinical stage of Alzheimer's disease ', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 4, pp. 64-75 . https://doi.org/10.1016/j.trci.2018.01.003
Alzheimer's and Dementia: Translational Research and Clinical Interventions, 4, 64-75. Elsevier Inc.
Weintraub, S, Carrillo, M C, Farias, S T, Goldberg, T E, Hendrix, J A, Jaeger, J, Knopman, D S, Langbaum, J B, Park, D C, Ropacki, M T, Sikkes, S A M, Welsh-Bohmer, K A, Bain, L J, Brashear, R, Budur, K, Graf, A, Martenyi, F, Storck, M S & Randolph, C 2018, ' Measuring cognition and function in the preclinical stage of Alzheimer's disease ', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 4, pp. 64-75 . https://doi.org/10.1016/j.trci.2018.01.003
The Alzheimer's Association's Research Roundtable met in November 2016 to explore how best to measure changes in cognition and function in the preclinical stage of Alzheimer's disease. This review will cover the tools and instruments currently availa
Autor:
Joel H. Kramer, Bruce Albala, Michael T. Ropacki, Craig W. Ritchie, Karen Ritchie, Jeffrey Kaye, John Harrison, Christopher Randolph
Publikováno v:
Ritchie, K, Ropacki, M, Albala, B, Harrison, J, Kaye, J, Kramer, J, Randolph, C & Ritchie, C W 2017, ' Recommended cognitive outcomes in preclinical Alzheimer's disease : Consensus statement from the European Prevention of Alzheimer's Dementia project ', Alzheimer's and Dementia, vol. 13, no. 2, pp. 186-195 . https://doi.org/10.1016/j.jalz.2016.07.154
The Horizon 2020/IMI European Prevention of Alzheimer's Dementia (EPAD) project will undertake large-scale proof-of-concept trials in predementia Alzheimer's disease (AD). Within EPAD, the monitoring of cognitive trajectories in the preclinical perio
Autor:
Joann Blessing-Moore, Dana Wallace, David A. Khan, Jeffrey G. Demain, James M. Tracy, John Oppenheimer, David M. Lang, Theodore M. Freeman, David B.K. Golden, Matthew Greenhawt, Chitra Dinakar, Diane E. Schuller, Christopher Randolph, David F. Graft, Richard A. Nicklas, David I. Bernstein, Jay M. Portnoy, Michael S. Tankersley
Publikováno v:
Annals of Allergy, Asthma & Immunology. 118:28-54
Autor:
Carine Pose, Christopher Randolph, Jeffrey Kaye, Karen Ritchie, Bruce Albala, Jessica A. Ash, Joel H. Kramer, Craig W. Ritchie, Marion Mortamais, John Harrison, Michael T. Ropacki
Publikováno v:
Mortamais, M, Ash, J A, Harrison, J, Kaye, J, Kramer, J, Randolph, C, Pose, C, Albala, B, Ropacki, M, Ritchie, C W & Ritchie, K 2017, ' Detecting cognitive changes in preclinical Alzheimer's disease : A review of its feasibility ', Alzheimer's and Dementia, vol. 13, no. 4, pp. 468-492 . https://doi.org/10.1016/j.jalz.2016.06.2365
Significant progress has been made in characterizing the biological changes occurring in preclinical Alzheimer's disease (AD). Cognitive dysfunction has been viewed, however, as a late-stage phenomenon, despite increasing evidence that changes may be