Zobrazeno 1 - 10
of 7 743
pro vyhledávání: '"Cancer stem cell"'
Publikováno v:
Seminars in Cancer Biology. 85:219-233
Mounting evidence has demonstrated that a myriad of developmental signaling pathways, such as the Wnt, Notch, Hedgehog and Hippo, are frequently deregulated and play a critical role in regulating cancer stem cell (CSC) activity in human cancers, incl
Publikováno v:
Seminars in Cancer Biology. 83:77-87
Despite the advances in treatment using chemotherapy or targeted therapies, due to static survival rates, non-small cell lung cancer (NSCLC) is the major cause of cancer-related deaths worldwide. Epigenetic-based therapies have been developed for NSC
Publikováno v:
Semin Cancer Biol
Brain tumors remain one of the most difficult tumors to treat and, depending on the diagnosis, have a poor prognosis. Of brain tumors, glioblastoma (GBM) is the most common malignant glioma and has a dismal prognosis, with only about 5% of patients a
Publikováno v:
Seminars in Cancer Biology. 82:150-161
Cancer initiating/ stem cells (CSCs) undergo self-renewal and differentiation that contributes to tumor initiation, recurrence and metastasis in colorectal cancer (CRC). Targeting of colorectal cancer stem cells (CCSCs) holds significant promise in e
Autor:
Yuehua Li, Ting Gao, Fuqiang Gong, Liming Xie, Xiaoping Wu, Baohong Jiang, Liting Tang, Yu Zhou, Hongbo Zhu, Yeru Tan
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:1723-1734
Background: Cancer stem cells could influence tumor recurrence and metastasis. Objective: To develop a new effective treatment modality targeting breast cancer stem cells (BCSCs) and to explore the role of Apatinib in BCSCs. Methods: BCSCs were isola
Autor:
Ajay Goel, Wenhao Weng
Publikováno v:
Semin Cancer Biol
Colorectal cancer (CRC) is one of most common malignancies worldwide and its incidence is still growing. In spite of recent advances in targeted therapies, their clinical efficacy has been limited, non-curative and unaffordable. A growing body of lit
Autor:
Soumya Ranjan Mishra, Chandra Sekhar Bhol, Sujit K. Bhutia, Samir Kumar Patra, Bishnu Prasad Behera, Srimanta Patra, Gautam Sethi, Prakash Priyadarshi Praharaj, Debasna P. Panigrahi, Kewal Kumar Mahapatra
Publikováno v:
Seminars in Cancer Biology. 80:205-217
Autophagy is an intracellular catabolic self-cannibalism that eliminates dysfunctional cytoplasmic cargos by the fusion of cargo-containing autophagosomes with lysosomes to maintain cyto-homeostasis. Autophagy sustains a dynamic interlink between cyt
Autor:
Zhiwei Sun, Hongmei Rosie Xing, Jingyuan Li, Doudou Liu, Bin Zeng, Qiting Zhao, Jianyu Wang, Ting Ye
Publikováno v:
FEBS Open Bio, Vol 11, Iss 7, Pp 1997-2007 (2021)
FEBS Open Bio
FEBS Open Bio
Mitophagy, a form of autophagy, plays a role in cancer development, progression and recurrence. Cancer stem cells (CSCs) also play a key role in these processes, although it not known whether mitophagy can regulate the stemness of CSCs. Here, we empl
Autor:
Goshi Shiota, Hiroyuki Tsuchiya
Publikováno v:
Tsuchiya, Hiroyuki. Shiota, Goshi. Immune evasion by cancer stem cells. Regenerative Therapy. 17. 20-33. doi:10.1016/j.reth.2021.02.006
Regenerative Therapy, Vol 17, Iss, Pp 20-33 (2021)
Regenerative Therapy
Regenerative Therapy, Vol 17, Iss, Pp 20-33 (2021)
Regenerative Therapy
Tumor immunity represents a new avenue for cancer therapy. Immune checkpoint inhibitors have successfully improved outcomes in several tumor types. In addition, currently, immune cell-based therapy is also attracting significant attention. However, t
Autor:
Jun Nishida, Shogo Ehata, Kohei Miyazono, Shimpei I. Kubota, Yusaku Momoi, Kosuke Miyakuni, Masafumi Kuroda
Publikováno v:
Cancer Science
Intratumoral heterogeneity, including in clear cell renal cell carcinoma, is a potential cause of drug resistance and metastatic cancer progression. We specified the heterogeneous population marked by endoglin (also known as CD105) in a preclinical m