Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Kevin J Harrington"'
Autor:
Mansour T. A. Sharabiani, Paul Carter, S.A. Bhide, Kevin J. Harrington, R. Shaikh, Isaac Garcia-Murillas, D.M. Allin, Katie L. Newbold, Khin Thway, D. Kim, D. Gonzales-de-Castro, Ben O'Leary, Mike Hubank
Publikováno v:
European Journal of Cancer. 103:165-175
Background Conventional biomarkers in thyroid cancer are not disease specific and fluctuate in advanced disease, making interpretation difficult. Circulating tumour DNA (ctDNA) has been shown to be a useful biomarker in other solid tumours. This is a
Autor:
Kelly Jones, Robert Huddart, Mansour T. A. Sharabiani, Susan Lalondrelle, Merina Ahmed, Kevin J. Harrington, Alison Tree, Shaista Hafeez
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 101:1168-1171
There is currently significant interest in the potential benefits of combining radiation and immune checkpoint blockade (ICB) to stimulate both regional and distant abscopal immune responses. In melanoma and lung cancer, patients who have received ra
Autor:
Jérôme Fayette, George R. Blumenschein, Joël Guigay, Everett E. Vokes, Tamara Rordorf, Caroline Even, Nabil F. Saba, Lara Carmen Iglesias Docampo, Manish Monga, Robert L. Ferris, Robert I. Haddad, Kevin J. Harrington, Lisa Licitra, Naomi Kiyota, Li Li, A. Dimitrios Colevas, Maura L. Gillison, Stefan Kasper, Makoto Tahara, Francis P. Worden, Mark Lynch
Publikováno v:
The Oncologist. 23:1079-1082
Nivolumab significantly improved overall survival (OS) vs investigator's choice (IC) of chemotherapy at the primary analysis of randomized, open-label, phase 3 CheckMate 141 in patients with recurrent or metastatic (R/M) squamous cell carcinoma of th
Autor:
Margaret A. Knowles, Gough G. Au, Carla S. Möller-Levet, David Mansfield, Alan Melcher, Richard G. Vile, Nicola E. Annels, Darren R. Shafren, M. Denyer, Rachel E. Butler, Guy Simpson, Kevin J. Harrington, Mehreen Arif, Hardev Pandha
Publikováno v:
Molecular Therapy: Oncolytics, Vol 9, Iss, Pp 1-12 (2018)
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics
As a clinical setting in which local live biological therapy is already well established, non-muscle invasive bladder cancer (NMIBC) presents intriguing opportunities for oncolytic virotherapy. Coxsackievirus A21 (CVA21) is a novel intercellular adhe
Publikováno v:
Oncotarget
The HOX and PBX gene families encode transcription factors that have key roles in establishing the identity of cells and tissues in early development. Over the last 20 years it has become apparent that they are also dysregulated in a wide range of so
Autor:
Andrew J. Hayes, Aadil A. Khan, Kevin J. Harrington, Henry G. Smith, Tim Pencavel, Michelle J. Wilkinson, Joan Kyula-Currie, Gráinne McEntee, Victoria Roulstone, David Mansfield
Publikováno v:
Oncotarget
Advanced extremity melanoma and sarcoma present a significant therapeutic challenge, requiring multimodality therapy to treat or even palliate disease. These aggressive tumours are relatively chemo-resistant, therefore new treatment approaches are ur
Autor:
Victoria Roulstone, Henry G. Smith, David Mansfield, Claire Gregory, Gráinne McEntee, Matthew C. Coffey, Michelle J. Wilkinson, Kevin J. Harrington, Joan N. Kyula
Publikováno v:
Oncotarget
// Grainne McEntee 1 , Joan N. Kyula 1 , David Mansfield 1 , Henry Smith 1, 2 , Michelle Wilkinson 1, 2 , Claire Gregory 1 , Victoria Roulstone 1 , Matt Coffey 3 , Kevin J. Harrington 1 1 Targeted Therapy Team, the Institute of Cancer Research, Londo
Publikováno v:
International Journal of Surgical Pathology. 26:31-33
Mucoepidermoid carcinoma (MEC) shows a wide morphologic spectrum, including epithelium with oncocytic or squamous metaplastic changes overlying a prominent cystic architecture, as well as tumor-associated lymphoid tissue. We illustrate a case of MEC
Autor:
Kevin J. Harrington
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 25(1)
A new way of delivering radiotherapy at very high dose rates is described and compared with conventional radiotherapy. The ultrahigh dose-rate therapy reduces damage to normal pig skin and exerts potent activity against spontaneous nasal tumors in ca
Autor:
Vijayvel Jayaprakash, Lisa Licitra, Nabil F. Saba, Jérôme Fayette, Joël Guigay, Naomi Kiyota, Robert L. Ferris, Kevin J. Harrington, Stefan Kasper, Li Li, Francis P. Worden, Caroline Even, Robert I. Haddad, Makoto Tahara, Maura L. Gillison, Lara Carmen Iglesias Docampo, Mark Lynch, Tamara Rordorf, Everett E. Vokes, George R. Blumenschein, A. Dimitrios Colevas
Publikováno v:
Oral oncology. 81
OBJECTIVES: We report 2-year results from CheckMate 141 to establish the long-term efficacy and safety profile of nivolumab and outcomes by tumor PD-L1 expression in patients with recurrent or metastatic (R/M),platinum-refractory squamous cell carcin