Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Thomas C. Foster"'
Publikováno v:
Aging (Albany NY)
We examined the contribution of N-methyl-D-aspartate receptor (NMDAR) subunits in the redox-mediated decline in NMDAR function during aging. GluN2A and GluN2B selective antagonists decreased peak NMDAR currents to a similar extent in young and aged a
Autor:
Ashok Kumar, Thomas C. Foster
Publikováno v:
Neurochemical Research. 44:38-48
Glutamate is the primary excitatory neurotransmitter in neurons and glia. N-methyl-D-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and kainate receptors are major ionotropic glutamate receptors. Glutamatergic neurotr
Publikováno v:
Antioxidants & Redox Signaling. 28:1724-1745
Oxidative stress increases in the brain with aging and neurodegenerative diseases. Previous work emphasized irreversible oxidative damage in relation to cognitive impairment. This research has evolved to consider a continuum of alterations, from redo
Publikováno v:
Behavioural Brain Research. 322:223-232
Increased human longevity has magnified the negative impact that aging can have on cognitive integrity of older individuals experiencing some decline in cognitive function. Approximately 30% of the elderly will have cognitive problems that influence