Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Daniel D. De Carvalho"'
Autor:
Wail Ba-alawi, Evelyne Lima-Fernandes, Jason W. Locasale, Daniel D. De Carvalho, Paul Savage, Ilias Ettayebi, Hellen Kuasne, Morag Park, Felicia Tai, Yunchi Ingrid Kao, Benjamin Haibe-Kains, Alexandra N. Fedor, Paul Guilhamon, Giacomo Grillo, Seyed Ali Madani Tonekaboni, Cheryl H. Arrowsmith, Xiaojing Liu, Constanza Martinez, Anne-Marie Fortier, Mathieu Lupien, Alex Murison, Geneviève Deblois, David W. Cescon
Publikováno v:
Cancer Discovery. 10:1312-1329
Tumor progression upon treatment arises from preexisting resistant cancer cells and/or adaptation of persister cancer cells committing to an expansion phase. Here, we show that evasion from viral mimicry response allows the growth of taxane-resistant
Autor:
Marie Jo Halaby, Vincenzo Bronte, Andreas Kloetgen, Trevor J. Pugh, David G. Brooks, Kebria Hezaveh, M. Teresa Ciudad, Tracy L. McGaha, Daniel D. De Carvalho, Mengdi Guo, David H. Munn, Sara Lamorte, Aristotelis Tsirigos, Bethany L. MacLeod, Marcus O. Butler, Stefano Ugel, Tiago Medina, Ankur Chakravarthy, Pamela S. Ohashi
Publikováno v:
Sci Immunol
General control nonderepressible 2 (GCN2) is an environmental sensor controlling transcription and translation in response to nutrient availability. Although GCN2 is a putative therapeutic target for immuno-oncology, its role in shaping the immune re
Autor:
Reema Deol, Tiago Medina, Rahul Shinde, Marie Jo Halaby, Yuriy Baglaenko, Zahi Touma, Sathi Babu Chodisetti, Kieran P. Manion, Haiyun Liu, Maria Eldh, Sara Lamorte, Kapil Chaudhary, Andreas Kloetgen, Drew Wallace, Kebria Hezaveh, Tracy L. McGaha, Ankur Chakravarthy, Aristotelis Tsirigos, David H. Munn, Joan E. Wither, Susanne Gabrielsson, Michael P. Madaio, Daniel D. De Carvalho, Buvana Ravishankar
Publikováno v:
Nature Immunology. 19:571-582
The transcription factor AhR modulates immunity at multiple levels. Here we report that phagocytes exposed to apoptotic cells exhibited rapid activation of AhR, which drove production of the cytokine IL-10. Activation of AhR was dependent on interact
Autor:
Mathieu Lupien, Yulia Jitkova, Michael Mullokandov, Helen Loo Yau, Rima Al-awar, James R. Hawley, Rose Hurren, Troy Ketela, S. Kim, Veronique Voisin, Neil MacLean, Daniel D. De Carvalho, Mark D. Minden, Geethu E. Thomas, Val A. Fajardo, Ahmed Aman, Zhenyue Hao, Zaza Khuchua, G. Wei Xu, Gary D. Bader, Richard P. Bazinet, Juan J. Aristizabal Henao, Mingjing Xu, Paul J. LeBlanc, Ayesh K. Seneviratne, Steven M. Claypool, Steven M. Chan, Xiaoming Wang, Atan Gross, Aaron D. Schimmer, Ken D. Stark, David Sharon, Raphaël Chouinard-Watkins, Danny V. Jeyaraju, Caitlin Schafer, Marcela Gronda
Summary Tafazzin (TAZ) is a mitochondrial transacylase that remodels the mitochondrial cardiolipin into its mature form. Through a CRISPR screen, we identified TAZ as necessary for the growth and viability of acute myeloid leukemia (AML) cells. Genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b74e60e809d7c98db8697836fef410
https://europepmc.org/articles/PMC7137093/
https://europepmc.org/articles/PMC7137093/
Autor:
Gary D. Bader, Troy Ketela, Veronique Voisin, Danny V. Jeyaraju, Dilshad H. Khan, G. Wei Xu, Sajid A. Marhon, Yulia Jitkova, Michael Mullokandov, Rob C. Laister, Aaron D. Schimmer, Xiaoming Wang, Rose Hurren, Daniel D. De Carvalho, Marcela Gronda, Ayesh K. Seneviratne, Zachary Blatman, Neil MacLean, Mark D. Minden, Atan Gross, Yan Wu
Publikováno v:
Blood. 136(1)
Through a clustered regularly insterspaced short palindromic repeats (CRISPR) screen to identify mitochondrial genes necessary for the growth of acute myeloid leukemia (AML) cells, we identified the mitochondrial outer membrane protein mitochondrial
Autor:
Peter A. Jones, Gangning Liang, David Roulois, Yadong Wang, Catherine A. O’Brien, Arnavaz Danesh, Rajat Singhania, Han Han, Trevor J. Pugh, Shu Yi Shen, Daniel D. De Carvalho, Helen Loo Yau
Publikováno v:
Cell. 162(5):961-973
SummaryDNA-demethylating agents have shown clinical anti-tumor efficacy via an unknown mechanism of action. Using a combination of experimental and bioinformatics analyses in colorectal cancer cells, we demonstrate that low-dose 5-AZA-CdR targets col
Autor:
Sabrina Müller, Daniel D. De Carvalho, David M. Underhill, George Y. Liu, Andrea J. Wolf, Gislâine A. Martins, Christopher N. Reyes, Moshe Arditi, Marisel Sanchez, Rajat Singhania, Stacey L. Kolar, Chihiro Ogawa
Publikováno v:
Cell hostmicrobe. 22(4)
Summary Humans do not usually develop effective immunity to Staphylococcus aureus reinfection. Using a murine model that mimics human infection, we show that lack of protective immunity to S. aureus systemic reinfection is associated with robust inte
Autor:
Peter A. Jones, Daniel D. De Carvalho, Xianghong Jasmine Zhou, Phillippa C. Taberlay, Tina B. Miranda, Gangning Liang, Chun-Chi Liu, Theresa K. Kelly, Jueng Soo You
Publikováno v:
Cell. 147:1283-1294
SummaryKey regulatory genes, suppressed by Polycomb and H3K27me3, become active during normal differentiation and induced reprogramming. Using the well-characterized enhancer/promoter pair of MYOD1 as a model, we have identified a critical role for e