Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Diwakar Davar"'
Publikováno v:
OncoTargets and Therapy. 13:10039-10061
Toll-like receptor 9 (TLR9) is a pattern recognition receptor that is predominantly located intracellularly in immune cells, including dendritic cells, macrophages, natural killer cells, and other antigen-presenting cells (APC). The primary ligands f
Autor:
Yana G. Najjar, Diwakar Davar, Xi Yang, Saba Shaikh, Greg M. Delgoffe, Yan Zang, Amy Rose, John M. Kirkwood, Hassane M. Zarour, Hong Wang, Jason J. Luke, Cindy Sander
Publikováno v:
Regular and young investigator award abstracts.
Background Immunotherapy has changed the treatment landscape for melanoma, although many patients (pts) do not respond to treatment. While there are likely multiple mechanisms of resistance at play, one key mechanism is the generation of an immunosup
Autor:
Hassane M. Zarour, Diwakar Davar
Publikováno v:
Biomarkers for Immunotherapy of Cancer ISBN: 9781493997725
Methods Mol Biol
Methods Mol Biol
Tumor development is characterized by the accumulation of mutational and epigenetic changes that transform normal cells and survival pathways into self-sustaining cells capable of untrammeled growth. Although multiple modalities including surgery, ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96bab0394177e85f73e465a3037e92e
https://doi.org/10.1007/978-1-4939-9773-2_2
https://doi.org/10.1007/978-1-4939-9773-2_2
Autor:
Alan J. Korman, Diwakar Davar, Cindy Sander, Mignane B. Ka, John M. Kirkwood, Julien Fourcade, Hassane M. Zarour, Hong Wang, Ornella Pagliano, Zhaojun Sun, Joe-Marc Chauvin, Sofiane Saada, Carmine Menna, Rada Amin
CD4+ Tregs impede T cell responses to tumors. They express multiple inhibitory receptors that support their suppressive functions, including T cell Ig and ITIM domain (TIGIT). In melanoma patients, we show that Tregs exhibit increased TIGIT expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b285657653ceffba41ce16464236057
https://europepmc.org/articles/PMC6124410/
https://europepmc.org/articles/PMC6124410/
Autor:
Amit Hemadri, Yana G. Najjar, Cindy Sander, Hassane M. Zarour, John M. Kirkwood, Amy Rose, Yan Lin, Huang Lin, Diwakar Davar
Publikováno v:
Journal of Clinical Oncology. 37:9572-9572
9572 Background: Retrospective studies suggest that various med could dichotomous effects in regards to immunotherapy. These include adverse (antibiotics) and positive (aspirin, beta-blockers) influences. To evaluate potential additive or detrimental
Autor:
Carmine Menna, Amirin Dzutsev, Marie Vétizou, Jonathan H. Badger, John M. Kirkwood, John McCullogh, Hassane M. Zarour, Giorgio Trinchieri, Diwakar Davar, Ornella Pagliano
Publikováno v:
Cancer Immunology Research. 7:IA38-IA38
Immunotherapy with blocking anti-PD1 monoclonal antibodies (a PD1 mAbs) has become one of the most potent therapies of melanoma, providing extended clinical benefits to 30-40% advanced melanoma patients. There is substantial evidence that pre-existin
Autor:
John M. Kirkwood, Yan Lin, Yana G. Najjar, Mark Sparrow, Ryan Massa, Diwakar Davar, Amy Rose, Heather Kelley, Huang Lin, David J. Mauro, Arthur M. Krieg
Publikováno v:
Journal of Clinical Oncology. 36:e21507-e21507
e21507Background: Prior reports have described an association with hepatic metastases and total TB with reduced response rates to anti-PD-1 treatment in subjects with advanced MEL. We explored base...
Publikováno v:
Journal of Skin Cancer, Vol 2011 (2011)
Journal of Skin Cancer
Journal of Skin Cancer
With an incidence that is increasing at 2–5% per year, cutaneous melanoma is an international scourge that disproportionately targets young individuals. Despite much research, the treatment of advanced disease is still quite challenging. Immunother