Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Mariano Severgnini"'
Autor:
Jiani Hu, Khanh T. Do, Geoffrey I. Shapiro, Emily M. Thrash, Claire Manuszak, Anita Giobbie-Hurder, Allison Powers, Sarah Kelland, Adrienne de Jonge, Mariano Severgnini
Publikováno v:
Cancer Immunology, Immunotherapy. 70:2991-3000
Checkpoint kinase 1 (CHK1) has dual roles in both the DNA damage response and in the innate immune response to genotoxic stress. The combination of CHK1 inhibition and immune checkpoint blockade has the potential to enhance anti-tumoral T-cell activa
Autor:
Joao Victor Machado Alessi, Biagio Ricciuti, Greg Jones, Gonzalo Recondo, Mizuki Nishino, Tim Forshew, Michael Cheng, Mariano Severgnini, Marissa N. Lawrence, Christine A. Lydon, Mark M. Awad
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
BackgroundCurrently available biomarkers are imperfect in their ability to predict responses to the multiple first-line treatment options available for patients with advanced non-small cell lung cancer (NSCLC). Having an early pharmacodynamic marker
Autor:
Jonathan D. Schoenfeld, Mizuki Nishino, F. Stephen Hodi, Raymond H. Mak, Michael Manos, Mariano Severgnini
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-7 (2019)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
Background Pneumonitis is a potential consequence of both lung-directed radiation and immune checkpoint blockade (ICB), particularly treatment with PD-1/PD-L1 inhibitors. Significant morbidity and mortality can result, and severe pneumonitis attribut
Autor:
Limor Cohen, Cloud P. Paweletz, Biagio Ricciuti, Anika E. Adeni, David R. Walt, Julianna Supplee, Reiko Nishihara, Pasi A. Jänne, Padric M. Garden, Mariano Severgnini, Alissa Keegan, Mark M. Awad
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundBlood-based biomarkers of anti-solid tumor immune checkpoint blockade (ICB) response are lacking. We hypothesized that changes in systemic cytokine levels with the initial doses of programmed cell death protein 1 (PD-1) pathway inhibitors w
Autor:
Danielle N. Margalit, F. Stephen Hodi, Robert I. Haddad, Roy B. Tishler, Mariano Severgnini, Jonathan D. Schoenfeld, Vishwajith Sridharan, Stephanie A. Lynch
Publikováno v:
Journal for Immunotherapy of Cancer
Background Preclinical studies suggest a synergistic effect between radiation, immunotherapy and anti-angiogenic therapy, although the mechanisms are unclear. Angiogenic cytokines are known to affect the immune system, and their levels may be associa