Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Holmen, Oddgeir"'
Autor:
Evans, Luke M., Tahmasbi, Rasool, Jones, Matthew, Vrieze, Scott I., Abecasis, Gonçalo R., Das, Sayantan, Bjelland, Doug W., deCandia, Teresa R., Abecasis, Gonçalo, Altshuler, David, Anderson, Carl A, Angius, Andrea, Barrett, Jeffrey C, Berndt, Sonja, Boehnke, Michael, Boomsma, Dorrett, Branham, Kari, Breen, Gerome, Brummett, Chad M, Busonero, Fabio, Campbell, Harry, Campbell, Peter, Chan, Andrew, Chen, Sai, Chew, Emily, Cocca, Massimiliano, Collins, Francis S, Corbin, Laura J, Cucca, Francesco, Danecek, Petr, de Bakker, Paul I W, Dedoussis, George, Dekker, Annelot, Delaneau, Olivier, Dorr, Marcus, Durbin, Richard, Farmaki, Aliki-Eleni, Ferrucci, Luigi, Forer, Lukas, Fraser, Ross M, Frayling, Timothy, Fuchsberger, Christian, Gabriel, Stacey, Gandin, Ilaria, Gasparini, Paolo, Gillies, Christopher E, Gilly, Arthur, Groop, Leif, Harrison, Tabitha, Hattersley, Andrew, Holmen, Oddgeir L, Hveem, Kristian, Iacono, William, Joshi, Amit, Kang, Hyun Min, Khalili, Hamed, Kooperberg, Charles, Koskinen, Seppo, Kretzler, Matthias, Kretzschmar, Warren, Kwong, Alan, Lee, James C, Levy, Shawn, Luo, Yang, Mahajan, Anubha, Marchini, Jonathan, McCarroll, Steven, McCarthy, Mark I, McCarthy, Shane, McGue, Matt, McInnis, Melvin, Meitinger, Thomas, Melzer, David, Mezzavilla, Massimo, Min, Josine L, Mohlke, Karen L, Myers, Richard M, Nauck, Matthias, Nickerson, Deborah, Palotie, Aarno, Pato, Carlos, Pato, Michele, Peters, Ulrike, Pirastu, Nicola, Rheenen, Wouter Van, Richards, J Brent, Ripatti, Samuli, Sala, Cinzia, Salomaa, Veikko, Sampson, Matthew G, Schlessinger, David, Schoen, Robert E, Schoenherr, Sebastian, Scott, Laura J, Sharp, Kevin, Sidore, Carlo, Slagboom, P Eline, Small, Kerrin, Smith, George Davey, Soranzo, Nicole, Spector, Timothy, Stambolian, Dwight, Swaroop, Anand, Swertz, Morris A, Teumer, Alexander, Timpson, Nicholas, Toniolo, Daniela, Traglia, Michela, Tuke, Marcus, Tuomilehto, Jaakko, den Berg, Leonard H Van, van Duijn, Cornelia M, Veldink, Jan, Vincent, John B, Volker, Uwe, Vrieze, Scott, Walter, Klaudia, Wijmenga, Cisca, Willer, Cristen, Wilson, James F, Wood, Andrew R, Zeggini, Eleftheria, Zhang, He, Yang, Jian, Goddard, Michael E., Visscher, Peter M., Keller, Matthew C.
Publikováno v:
Heredity. 121:616-630
Heritability is a fundamental parameter in genetics. Traditional estimates based on family or twin studies can be biased due to shared environmental or non-additive genetic variance. Alternatively, those based on genotyped or imputed variants typical
Autor:
Justice, Anne E, Karaderi, Tugce, Highland, Heather M, Young, Kristin L, Graff, Mariaelisa, Lu, Yingchang, Turcot, Valérie, Auer, Paul L, Fine, Rebecca S, Guo, Xiuqing, Schurmann, Claudia, Lempradl, Adelheid, Marouli, Eirini, Mahajan, Anubha, Winkler, Thomas W, Locke, Adam E, Medina-Gomez, Carolina, Esko, Tõnu, Vedantam, Sailaja, Giri, Ayush, Lo, Ken Sin, Alfred, Tamuno, Mudgal, Poorva, Ng, Maggie CY, Heard-Costa, Nancy L, Feitosa, Mary F, Manning, Alisa K, Willems, Sara M, Sivapalaratnam, Suthesh, Abecasis, Goncalo, Alam, Dewan S, Allison, Matthew, Amouyel, Philippe, Arzumanyan, Zorayr, Balkau, Beverley, Bastarache, Lisa, Bergmann, Sven, Bielak, Lawrence F, Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A, Bork-Jensen, Jette, Bottinger, Erwin P, Bowden, Donald W, Brandslund, Ivan, Broer, Linda, Burt, Amber A, Butterworth, Adam S, Caulfield, Mark J, Cesana, Giancarlo, Chambers, John C, Chasman, Daniel I, Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y, Collins, Francis S, Cook, James P, Cox, Amanda J, Crosslin, David S, Danesh, John, de Bakker, Paul IW, Denus, Simon de, Mutsert, Renée de, Dedoussis, George, Demerath, Ellen W, Dennis, Joe G, Denny, Josh C, Angelantonio, Emanuele Di, Dörr, Marcus, Drenos, Fotios, Dubé, Marie-Pierre, Dunning, Alison M, Easton, Douglas F, Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C, Fornage, Myriam, Fox, Caroline S, Franks, Paul W, Friedrich, Nele, Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Girotto, Giorgia, Gorski, Mathias, Grallert, Harald, Grarup, Niels, Grove, Megan L, Gustafsson, Stefan, Haessler, Jeff, Hansen, Torben, Hattersley, Andrew T, Hayward, Caroline, Heid, Iris M, Holmen, Oddgeir L, Hovingh, G Kees, Howson, Joanna MM, Hu, Yao, Hung, Yi-Jen, Hveem, Kristian, Ikram, M Arfan, Ingelsson, Erik, Jackson, Anne U, Jarvik, Gail P, Jia, Yucheng, Jørgensen, Torben, Jousilahti, Pekka, Justesen, Johanne M, Kahali, Bratati, Karaleftheri, Maria, Kardia, Sharon LR, Karpe, Fredrik, Kee, Frank, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S, Kovacs, Peter, Krämer, Bernhard K, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A, Lamparter, David, Lange, Leslie A, Langenberg, Claudia, Larson, Eric B, Lee, Nanette R, Lee, Wen-Jane, Lehtimäki, Terho, Lewis, Cora E, Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J, Luan, Jian'an, Lyytikäinen, Leo-Pekka, MacGregor, Stuart, Mägi, Reedik, Männistö, Satu, Marenne, Gaëlle, Marten, Jonathan, Masca, Nicholas GD, McCarthy, Mark I, Meidtner, Karina, Mihailov, Evelin, Moilanen, Leena, Moitry, Marie, Mook-Kanamori, Dennis O, Morgan, Anna, Morris, Andrew P, Müller-Nurasyid, Martina, Munroe, Patricia B, Narisu, Narisu, Nelson, Christopher P, Neville, Matt, Ntalla, Ioanna, O'Connell, Jeffrey R, Owen, Katharine R, Pedersen, Oluf, Peloso, Gina M, Pennell, Craig E, Perola, Markus, Perry, James A, Perry, John RB, Pers, Tune H, Ewing, Ailith, Polasek, Ozren, Raitakari, Olli T, Rasheed, Asif, Raulerson, Chelsea K, Rauramaa, Rainer, Reilly, Dermot F, Reiner, Alex P, Ridker, Paul M, Rivas, Manuel A, Robertson, Neil R, Robino, Antonietta, Rudan, Igor, Ruth, Katherine S, Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J, Schreiner, Pamela J, Schulze, Matthias B, Scott, Robert A, Segura-Lepe, Marcelo, Sim, Xueling, Slater, Andrew J, Small, Kerrin S, Smith, Blair H, Smith, Jennifer A, Southam, Lorraine, Spector, Timothy D, Speliotes, Elizabeth K, Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E, Strauch, Konstantin, Stringham, Heather M, Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swart, Karin MA, Tardif, Jean-Claude, Taylor, Kent D, Teumer, Alexander, Thompson, Deborah J, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H, Tönjes, Anke, Torres, Mina, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Uitterlinden, André G, Uusitupa, Matti, van Duijn, Cornelia M, Vanhala, Mauno, Varma, Rohit, Vermeulen, Sita H, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F, Vuckovic, Dragana, Wagenknecht, Lynne E, Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A, Wang, Shuai, Wareham, Nicholas J, Warren, Helen R, Waterworth, Dawn M, Wessel, Jennifer, White, Harvey D, Willer, Cristen J, Wilson, James G, Wood, Andrew R, Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yerges-Armstrong, Laura M, Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zheng, He, Zhou, Wei, Zillikens, M Carola, CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CH, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct, ReproGen Consortium, T2D-Genes Consortium, MAGIC Investigators, Rivadeneira, Fernando, Borecki, Ingrid B, Pospisilik, J Andrew, Deloukas, Panos, Frayling, Timothy M, Lettre, Guillaume, Mohlke, Karen L, Rotter, Jerome I, Kutalik, Zoltán, Hirschhorn, Joel N, Cupples, L Adrienne, Loos, Ruth JF, North, Kari E, Lindgren, Cecilia M
Publikováno v:
Nature Genetics, 51, 3, pp. 452-469
Nature Genetics, 51, 452-469
Nature genetics, 51(3), 452-469. Nature Publishing Group
Nature Genetics
Nature genetics
Nature Genetics, 51(3), 452-469. Nature Publishing Group
Nature genetics, vol. 51, no. 3, pp. 452-469
Nat. Genet. 51, 452–469 (2019)
Justice, A E, Karaderi, T, Highland, H M, Young, K L, Graff, M, Lu, Y, Turcot, V, Auer, P L, Fine, R S, Guo, X, Schurmann, C, Lempradl, A, Marouli, E, Mahajan, A, Winkler, T W, Locke, A E, Medina-Gomez, C, Esko, T N, Vedantam, S, Giri, A, Lo, K S, Alfred, T, Mudgal, P, Ng, M C Y, Heard-Costa, N L, Feitosa, M F, Manning, A K, Willems, S M, Sivapalaratnam, S, Abecasis, G, Alam, D S, Allison, M, Amouyel, P, Arzumanyan, Z, Balkau, B, Bastarache, L, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Böger, C A, Bork-Jensen, J, Bottinger, E P, Bowden, D W, Brandslund, I, Li, J, Swart, K M A, Vermeulen, S H, CHD Exome+ Consortium, Frayling, T M, Lettre, G, Mohlke, K L, Rotter, J I, Kutalik, Z, Hirschhorn, J N, Cupples, L A, Loos, R J F, North, K E & Lindgren, C M 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics, vol. 51, pp. 452–469 . https://doi.org/10.1038/s41588-018-0334-2
Justice, A E, Karaderi, T, Highland, H M, Young, K L, Graff, M, Lu, Y, Turcot, V, Auer, P L, Fine, R S, Guo, X, Schurmann, C, Lempradl, A, Marouli, E, Mahajan, A, Winkler, T W, Locke, A E, Medina-Gomez, C, Esko, T, Vedantam, S, Giri, A, Lo, K S, Alfred, T, Mudgal, P, Ng, M C Y, Heard-Costa, N L, Feitosa, M F, Manning, A K, Willems, S M, Sivapalaratnam, S, Abecasis, G, Alam, D S, Allison, M, Amouyel, P, Arzumanyan, Z, Balkau, B, Bastarache, L, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Böger, C A, Bork-Jensen, J, Bottinger, E P, Bowden, D W, Brandslund, I, Broer, L, Burt, A A, Butterworth, A S, Caulfield, M J, Cesana, G, Chambers, J C, Chasman, D I, Chen, Y-D I, Chowdhury, R, Christensen, C, Chu, A Y, Collins, F S, Cook, J P, Cox, A J, Crosslin, D S, Danesh, J, de Bakker, P I W, de Denus, S, de Mutsert, R, Dedoussis, G, Demerath, E W, Dennis, J G, Denny, J C, Di Angelantonio, E, Dörr, M, Drenos, F, Dubé, M-P, Dunning, A M, Easton, D F, Elliott, P, Evangelou, E, Farmaki, A-E, Feng, S, Ferrannini, E, Ferrieres, J, Florez, J C, Fornage, M, Fox, C S, Franks, P W, Friedrich, N, Gan, W, Gandin, I, Gasparini, P, Giedraitis, V, Girotto, G, Gorski, M, Grallert, H, Grarup, N, Grove, M L, Gustafsson, S, Haessler, J, Hansen, T, Hattersley, A T, Hayward, C, Heid, I M, Holmen, O L, Kees Hovingh, G, Howson, J M M, Hu, Y, Hung, Y-J, Hveem, K, Ikram, M A, Ingelsson, E, Jackson, A U, Jarvik, G P, Jia, Y, Jørgensen, T, Jousilahti, P, Justesen, J M, Kahali, B, Karaleftheri, M, Kardia, S L R, Karpe, F, Kee, F, Kitajima, H, Komulainen, P, Kooner, J S, Kovacs, P, Krämer, B K, Kuulasmaa, K, Kuusisto, J, Laakso, M, Lakka, T A, Lamparter, D, Lange, L A, Langenberg, C, Larson, E B, Lee, N R, Lee, W-J, Lehtimäki, T, Lewis, C E, Li, H, Li, J, Li-Gao, R, Lin, L-A, Lin, X, Lind, L, Lindström, J, Linneberg, A, Liu, C-T, Liu, D J, Luan, J, Lyytikäinen, L-P, MacGregor, S, Mägi, R, Männistö, S, Marenne, G, Marten, J, Masca, N G D, McCarthy, M I, Meidtner, K, Mihailov, E, Moilanen, L, Moitry, M, Mook-Kanamori, D O, Morgan, A, Morris, A P, Müller-Nurasyid, M, Munroe, P B, Narisu, N, Nelson, C P, Neville, M, Ntalla, I, Owen, K R, O'Connell, J R, Pedersen, O, Peloso, G M, Pennell, C E, Perola, M, Perry, J A, Perry, J R B, Pers, T H, Ewing, A, Polasek, O, Raitakari, O T, Rasheed, A, Raulerson, C K, Rauramaa, R, Reilly, D F, Reiner, A P, Ridker, P M, Rivas, M A, Robertson, N R, Robino, A, Rudan, I, Ruth, K S, Saleheen, D, Salomaa, V, Samani, N J, Schreiner, P J, Schulze, M B, Scott, R A, Segura-Lepe, M, Sim, X, Slater, A J, Small, K S, Smith, B H, Smith, J A, Southam, L, Spector, T D, Speliotes, E K, Stefansson, K, Steinthorsdottir, V, Stirrups, K E, Strauch, K, Stringham, H M, Stumvoll, M, Sun, L, Surendran, P, Swart, K M A, Tardif, J-C, Taylor, K D, Teumer, A, Thompson, D J, Thorleifsson, G, Thorsteinsdottir, U, Thuesen, B H, Tönjes, A, Torres, M, Tsafantakis, E, Tuomilehto, J, Uitterlinden, A G, Uusitupa, M, van Duijn, C M, Vanhala, M, Varma, R, Vermeulen, S H, Vestergaard, H, Vitart, V, Vogt, T F, Vuckovic, D, Wagenknecht, L E, Walker, M, Wallentin, L, Wang, F, Wang, C A, Wang, S, Wareham, N J, Warren, H R, Waterworth, D M, Wessel, J, White, H D, Willer, C J, Wilson, J G, Wood, A R, Wu, Y, Yaghootkar, H, Yao, J, Yerges-Armstrong, L M, Young, R, Zeggini, E, Zhan, X, Zhang, W, Hua Zhao, J, Zhao, W, Zheng, H, Zhou, W, Zillikens, M C, CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, EPIC-CVD consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Rivadeneira, F, Borecki, I B, Pospisilik, J A, Deloukas, P, Frayling, T M, Lettre, G, Mohlke, K L, Rotter, J I, Kutalik, Z, Hirschhorn, J N, Cupples, L A, Loos, R J F, North, K E & Lindgren, C M 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics, vol. 51, no. 3, pp. 452-469 . https://doi.org/10.1038/s41588-018-0334-2
CHD Exome+ Consortium 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics, vol. 51, no. 3, pp. 452-469 . https://doi.org/10.1038/s41588-018-0334-2
Nature Genetics, 51(3), 452
T2D-Genes Consortium, The MAGIC Investigators, CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct & ReproGen Consortium 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics, vol. 51, no. 3, pp. 452-469 . https://doi.org/10.1038/s41588-018-0334-2
2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics . https://doi.org/10.1038/s41588-018-0334-2
CHD Exome+ Consortium 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body fat distribution ', Nature Genetics, vol. xx, no. xx, xx, pp. xx . https://doi.org/10.1038/s41588-018-0334-2
Nature Genetics, 51. Nature Publishing Group
Justice, A E, Karaderi, T, Highland, H M, Young, K L, Graff, M, Lu, Y, Turcot, V, Auer, P L, Fine, R S, Guo, X, Schurmann, C, Lempradl, A, Marouli, E, Mahajan, A, Winkler, T W, Locke, A E, Medina-Gomez, C, Esko, T, Vedantam, S, Giri, A, Lo, K S, Alfred, T, Mudgal, P, Ng, M C Y, Heard-Costa, N L, Feitosa, M F, Manning, A K, Willems, S M, Sivapalaratnam, S, Abecasis, G, Alam, D S, Allison, M, Amouyel, P, Arzumanyan, Z, Balkau, B, Bastarache, L, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Böger, C A, Bork-Jensen, J, Bottinger, E P, Bowden, D W, Brandslund, I, Christensen, C, Hansen, T, Thuesen, B H & CHD Exome+ Consortium 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics, vol. 51, no. 3, pp. 452-469 . https://doi.org/10.1038/s41588-018-0334-2
Nature Genetics, 51, 452-469
Nature genetics, 51(3), 452-469. Nature Publishing Group
Nature Genetics
Nature genetics
Nature Genetics, 51(3), 452-469. Nature Publishing Group
Nature genetics, vol. 51, no. 3, pp. 452-469
Nat. Genet. 51, 452–469 (2019)
Justice, A E, Karaderi, T, Highland, H M, Young, K L, Graff, M, Lu, Y, Turcot, V, Auer, P L, Fine, R S, Guo, X, Schurmann, C, Lempradl, A, Marouli, E, Mahajan, A, Winkler, T W, Locke, A E, Medina-Gomez, C, Esko, T N, Vedantam, S, Giri, A, Lo, K S, Alfred, T, Mudgal, P, Ng, M C Y, Heard-Costa, N L, Feitosa, M F, Manning, A K, Willems, S M, Sivapalaratnam, S, Abecasis, G, Alam, D S, Allison, M, Amouyel, P, Arzumanyan, Z, Balkau, B, Bastarache, L, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Böger, C A, Bork-Jensen, J, Bottinger, E P, Bowden, D W, Brandslund, I, Li, J, Swart, K M A, Vermeulen, S H, CHD Exome+ Consortium, Frayling, T M, Lettre, G, Mohlke, K L, Rotter, J I, Kutalik, Z, Hirschhorn, J N, Cupples, L A, Loos, R J F, North, K E & Lindgren, C M 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics, vol. 51, pp. 452–469 . https://doi.org/10.1038/s41588-018-0334-2
Justice, A E, Karaderi, T, Highland, H M, Young, K L, Graff, M, Lu, Y, Turcot, V, Auer, P L, Fine, R S, Guo, X, Schurmann, C, Lempradl, A, Marouli, E, Mahajan, A, Winkler, T W, Locke, A E, Medina-Gomez, C, Esko, T, Vedantam, S, Giri, A, Lo, K S, Alfred, T, Mudgal, P, Ng, M C Y, Heard-Costa, N L, Feitosa, M F, Manning, A K, Willems, S M, Sivapalaratnam, S, Abecasis, G, Alam, D S, Allison, M, Amouyel, P, Arzumanyan, Z, Balkau, B, Bastarache, L, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Böger, C A, Bork-Jensen, J, Bottinger, E P, Bowden, D W, Brandslund, I, Broer, L, Burt, A A, Butterworth, A S, Caulfield, M J, Cesana, G, Chambers, J C, Chasman, D I, Chen, Y-D I, Chowdhury, R, Christensen, C, Chu, A Y, Collins, F S, Cook, J P, Cox, A J, Crosslin, D S, Danesh, J, de Bakker, P I W, de Denus, S, de Mutsert, R, Dedoussis, G, Demerath, E W, Dennis, J G, Denny, J C, Di Angelantonio, E, Dörr, M, Drenos, F, Dubé, M-P, Dunning, A M, Easton, D F, Elliott, P, Evangelou, E, Farmaki, A-E, Feng, S, Ferrannini, E, Ferrieres, J, Florez, J C, Fornage, M, Fox, C S, Franks, P W, Friedrich, N, Gan, W, Gandin, I, Gasparini, P, Giedraitis, V, Girotto, G, Gorski, M, Grallert, H, Grarup, N, Grove, M L, Gustafsson, S, Haessler, J, Hansen, T, Hattersley, A T, Hayward, C, Heid, I M, Holmen, O L, Kees Hovingh, G, Howson, J M M, Hu, Y, Hung, Y-J, Hveem, K, Ikram, M A, Ingelsson, E, Jackson, A U, Jarvik, G P, Jia, Y, Jørgensen, T, Jousilahti, P, Justesen, J M, Kahali, B, Karaleftheri, M, Kardia, S L R, Karpe, F, Kee, F, Kitajima, H, Komulainen, P, Kooner, J S, Kovacs, P, Krämer, B K, Kuulasmaa, K, Kuusisto, J, Laakso, M, Lakka, T A, Lamparter, D, Lange, L A, Langenberg, C, Larson, E B, Lee, N R, Lee, W-J, Lehtimäki, T, Lewis, C E, Li, H, Li, J, Li-Gao, R, Lin, L-A, Lin, X, Lind, L, Lindström, J, Linneberg, A, Liu, C-T, Liu, D J, Luan, J, Lyytikäinen, L-P, MacGregor, S, Mägi, R, Männistö, S, Marenne, G, Marten, J, Masca, N G D, McCarthy, M I, Meidtner, K, Mihailov, E, Moilanen, L, Moitry, M, Mook-Kanamori, D O, Morgan, A, Morris, A P, Müller-Nurasyid, M, Munroe, P B, Narisu, N, Nelson, C P, Neville, M, Ntalla, I, Owen, K R, O'Connell, J R, Pedersen, O, Peloso, G M, Pennell, C E, Perola, M, Perry, J A, Perry, J R B, Pers, T H, Ewing, A, Polasek, O, Raitakari, O T, Rasheed, A, Raulerson, C K, Rauramaa, R, Reilly, D F, Reiner, A P, Ridker, P M, Rivas, M A, Robertson, N R, Robino, A, Rudan, I, Ruth, K S, Saleheen, D, Salomaa, V, Samani, N J, Schreiner, P J, Schulze, M B, Scott, R A, Segura-Lepe, M, Sim, X, Slater, A J, Small, K S, Smith, B H, Smith, J A, Southam, L, Spector, T D, Speliotes, E K, Stefansson, K, Steinthorsdottir, V, Stirrups, K E, Strauch, K, Stringham, H M, Stumvoll, M, Sun, L, Surendran, P, Swart, K M A, Tardif, J-C, Taylor, K D, Teumer, A, Thompson, D J, Thorleifsson, G, Thorsteinsdottir, U, Thuesen, B H, Tönjes, A, Torres, M, Tsafantakis, E, Tuomilehto, J, Uitterlinden, A G, Uusitupa, M, van Duijn, C M, Vanhala, M, Varma, R, Vermeulen, S H, Vestergaard, H, Vitart, V, Vogt, T F, Vuckovic, D, Wagenknecht, L E, Walker, M, Wallentin, L, Wang, F, Wang, C A, Wang, S, Wareham, N J, Warren, H R, Waterworth, D M, Wessel, J, White, H D, Willer, C J, Wilson, J G, Wood, A R, Wu, Y, Yaghootkar, H, Yao, J, Yerges-Armstrong, L M, Young, R, Zeggini, E, Zhan, X, Zhang, W, Hua Zhao, J, Zhao, W, Zheng, H, Zhou, W, Zillikens, M C, CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, EPIC-CVD consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Rivadeneira, F, Borecki, I B, Pospisilik, J A, Deloukas, P, Frayling, T M, Lettre, G, Mohlke, K L, Rotter, J I, Kutalik, Z, Hirschhorn, J N, Cupples, L A, Loos, R J F, North, K E & Lindgren, C M 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics, vol. 51, no. 3, pp. 452-469 . https://doi.org/10.1038/s41588-018-0334-2
CHD Exome+ Consortium 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics, vol. 51, no. 3, pp. 452-469 . https://doi.org/10.1038/s41588-018-0334-2
Nature Genetics, 51(3), 452
T2D-Genes Consortium, The MAGIC Investigators, CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct & ReproGen Consortium 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics, vol. 51, no. 3, pp. 452-469 . https://doi.org/10.1038/s41588-018-0334-2
2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics . https://doi.org/10.1038/s41588-018-0334-2
CHD Exome+ Consortium 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body fat distribution ', Nature Genetics, vol. xx, no. xx, xx, pp. xx . https://doi.org/10.1038/s41588-018-0334-2
Nature Genetics, 51. Nature Publishing Group
Justice, A E, Karaderi, T, Highland, H M, Young, K L, Graff, M, Lu, Y, Turcot, V, Auer, P L, Fine, R S, Guo, X, Schurmann, C, Lempradl, A, Marouli, E, Mahajan, A, Winkler, T W, Locke, A E, Medina-Gomez, C, Esko, T, Vedantam, S, Giri, A, Lo, K S, Alfred, T, Mudgal, P, Ng, M C Y, Heard-Costa, N L, Feitosa, M F, Manning, A K, Willems, S M, Sivapalaratnam, S, Abecasis, G, Alam, D S, Allison, M, Amouyel, P, Arzumanyan, Z, Balkau, B, Bastarache, L, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Böger, C A, Bork-Jensen, J, Bottinger, E P, Bowden, D W, Brandslund, I, Christensen, C, Hansen, T, Thuesen, B H & CHD Exome+ Consortium 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics, vol. 51, no. 3, pp. 452-469 . https://doi.org/10.1038/s41588-018-0334-2
Body fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site va
Autor:
Alison Pattie, Ailith Pirie, Francis S. Collins, Charles Kooperberg, Nienke van Leeuwen, Carmel Moore, Sharon L.R. Kardia, Neil R. Robertson, Lisa Bastarache, Allan Linneberg, Peter T. Campbell, Helena Kuivaniemi, Struan F.A. Grant, Sascha Fauser, Sekar Kathiresan, Lars Lind, Erin B. Ware, Olli T. Raitakari, Dawn M. Waterworth, James G. Wilson, Markus Perola, Chris J. Packard, Michelle L. O'Donoghue, Fredrik Karpe, Roel A. Ophoff, Sailaja Vedantam, Artitaya Lophatananon, Uwe Völker, Emmanouil Tsafantakis, Hakon Hakonarson, Dajiang J. Liu, Craig E. Pennell, Xueling Sim, Jennifer E. Huffman, Sandosh Padmanabhan, Digna R. Velez Edwards, Michiel L. Bots, Ayush Giri, Renée de Mutsert, Emanuele Di Angelantonio, Nicholas J. Wareham, Jin Li, Gail P. Jarvik, Evangelos Evangelou, Anne Tybjærg-Hansen, Patricia B. Munroe, Penny Gordon-Larsen, Lia E. Bang, Ivan Brandslund, Hester M. den Ruijter, Jussi Hernesniemi, Nancy L. Heard-Costa, Angela L. Mazul, Jonathan Tyrer, Danish Saleheen, Mark J. Caulfield, John Andrew Pospisilik, Annette Peters, Caroline Hayward, Iris M. Heid, J. Wouter Jukema, Valérie Turcot, Matt Neville, Rudolf Uher, Patricia A. Peyser, Jessica D. Faul, Asif Rasheed, Shuai Wang, John C. Chambers, Jordi Corominas Galbany, Murray H. Brilliant, Yucheng Jia, Torben Hansen, Veikko Salomaa, Mary F. Feitosa, Mathias Gorski, Li-An Lin, George Dedoussis, Honghuang Lin, Ethan M. Lange, Veronique Vitart, Bratati Kahali, Alexander Teumer, Jerome I. Rotter, Wayne H-H Sheu, Vilmantas Giedraitis, Aliki-Eleni Farmaki, Lorraine Southam, Ele Ferrannini, Anette P. Gjesing, Krina T. Zondervan, Stavroula Kanoni, David J. Roberts, Rebecca S. Fine, Svati H. Shah, Tugce Karaderi, Claudia Langenberg, Stefan Johansson, Elizabeth K. Speliotes, Alexander P. Reiner, Ching-Ti Liu, Yiqin Wang, Pål R. Njølstad, Gabriel Cuellar-Partida, Amanda J. Cox, Tim D. Spector, Paul W. Franks, Anke Tönjes, John D. Rioux, Jeffrey Haessler, Paul L. Auer, Ingrid B. Borecki, Deborah J. Thompson, Weihua Zhang, John R. B. Perry, Paul Elliott, Folkert W. Asselbergs, Myriam Fornage, Ken Sin Lo, Marie Moitry, Paul Mitchell, Martin den Heijer, Zoltán Kutalik, Tune H. Pers, Kari Stefansson, Kari Kuulasmaa, Robert E. Schoen, Mark C.H. De Groot, Laura M. Yerges-Armstrong, Jing Hua Zhao, Beverley Balkau, Peggy L. Peissig, Michael Boehnke, Janie Corley, Katharine R. Owen, Unnur Thorsteinsdottir, Naveed Sattar, Sita H. Vermeulen, Thomas N. Person, Mark I. McCarthy, Paul I.W. de Bakker, David Lamparter, Poorva Mudgal, Nicholette D. Palmer, Maria Karaleftheri, Jan-Håkan Jansson, Ozren Polasek, Ruth J. F. Loos, Daniel R. Witte, Dermot F. Reilly, Anubha Mahajan, Stella Trompet, James A. Perry, Yingchang Lu, Claudia Schurmann, Yii-Der Ida Chen, Hidetoshi Kitajima, Dale R. Nyholt, John Danesh, Pamela J. Schreiner, Narisu Narisu, Jose C. Florez, Adelheid Lempradl, Gerome Breen, Torben Jørgensen, Anu Loukola, Joe Dennis, Hans-Jörgen Grabe, Vilmundur Gudnason, Timo A. Lakka, Heather M. Highland, Sven Bergmann, Marie-Pierre Dubé, Giovanni Veronesi, Martina Müller-Nurasyid, Jaakko Tuomilehto, Nele Friedrich, Joel N. Hirschhorn, Pia R. Kamstrup, Nilesh J. Samani, Josh C. Denny, Mika Kähönen, Massimiliano Cocca, Liang Sun, Karina Meidtner, Carsten A. Böger, Sara M. Willems, Marcelo P. Segura-Lepe, Johanna Kuusisto, Hanieh Yaghootkar, Konstantin Strauch, Ruth Frikke-Schmidt, Jane Gibson, Matti Uusitupa, Oscar H. Franco, Yongmei Liu, Heather M. Stringham, Rohit Varma, Grant W. Montgomery, Dennis O. Mook-Kanamori, Stefania Cappellani, Paul L. Huang, Albert V. Smith, Eric Kim, Anke R. Hammerschlag, Katherine S. Ruth, Carolina Medina-Gomez, Gerard Pasterkamp, Cristen J. Willer, Alisa K. Manning, Frida Renström, René S. Kahn, Lili Milani, Feijie Wang, Tessel E. Galesloot, Fernando Rivadeneira, Leo-Pekka Lyytikäinen, Adam S. Butterworth, Tamara B. Harris, Matthew A. Allison, Paul M. Ridker, David J. Carey, Todd L. Edwards, Panos Deloukas, Xiuqing Guo, Lawrence F. Bielak, Leena Moilanen, Heiner Boeing, Peter Kovacs, Karen L. Mohlke, Myriam Rheinberger, Cramer Christensen, Betina H. Thuesen, Mike A. Nalls, Erik Ingelsson, Nicholas G. D. Masca, Colin N. A. Palmer, Audrey E. Hendricks, Linda Broer, Vanisha Mistry, Praveen Surendran, Audrey Y. Chu, Rainer Rauramaa, Angela D'Eustacchio, Helen Griffiths, Satu Männistö, Patrick T. Ellinor, Terho Lehtimäki, Katherine E. Tansey, I. Sadaf Farooqi, Gaëlle Marenne, Anneke I. den Hollander, Jessica van Setten, Hannu Puolijoki, Tinca J. C. Polderman, Timothy M. Frayling, Niels Grarup, Eric Boerwinkle, Gonçalo R. Abecasis, Adam E. Locke, Mengmeng Du, Manuel A. Rivas, Philippe Amouyel, Jaakko Kaprio, Leslie A. Lange, Loes M. Olde Loohuis, Trevor A. Mori, Lambertus A. Kiemeney, Wei Zhao, Eva Rb Petersen, Huaixing Li, Thomas W. Winkler, Tellervo Korhonen, Kathleen Stirrups, Jean Ferrières, Wei Zhou, Ian J. Deary, Guillaume Lettre, M. Arfan Ikram, Alex W. Hewitt, Marit E. Jørgensen, Ian Ford, Liang He, Mark Walker, Stefan Gustafsson, Andre Franke, Yao Hu, Jaana Lindström, Jonathan P. Bradfield, Anne E. Justice, Kristin L. Young, Sander W. van der Laan, Shuang Feng, Yadav Sapkota, Douglas F. Easton, Cornelia M. van Duijn, Amy J. Swift, Kjell Nikus, Helen R. Warren, Christian Theil Have, Wei Gan, Steven A. Lubitz, Harvey D. White, Pirjo Komulainen, John M. Starr, Jeffrey R. O'Connel, Anette Varbo, Daniel I. Chasman, Ruifang Li-Gao, Lynne E. Wagenknecht, Matthias Blüher, Xiaowei Zhan, Thomas F. Vogt, Eleftheria Zeggini, Tamuno Alfred, Katja K.H. Aben, Lars Wallentin, Joanna M. M. Howson, Jie Yao, Eulalia Catamo, Henrik Vestergaard, Gina M. Peloso, Markku Laakso, Matthias B. Schulze, Hayato Tada, Jennifer Wessel, Andrew R. Wood, Erwin P. Bottinger, Cora E. Lewis, Robin Young, Carol A. Wang, Oddgeir L. Holmen, Andrew J. Slater, Jean-Claude Tardif, Xu Lin, Inês Barroso, Gail Davies, Tibor V. Varga, Andrew J. Lotery, Igor Rudan, Andrew T. Hattersley, Michael Stumvoll, David Ellinghaus, Andrew C. Heath, Frank Kee, Christopher P. Nelson, Donald W. Bowden, Alison M. Dunning, Marianne Benn, Oluf Pedersen, Amber A. Burt, Aniruddh P. Patel, G. Kees Hovingh, David S. Crosslin, Gorm B. Jensen, Keng-Hung Lin, Dewan S. Alam, Jian'an Luan, Ying Wu, Tõnu Esko, Kathleen Mullan Harris, Antonietta Robino, Anne U. Jackson, Eirini Marouli, Robert A. Scott, Jette Bork-Jensen, Olov Rolandsson, Nanette R. Lee, Gerard Tromp, Megan L. Grove, Suthesh Sivapalaratnam, Sameer E. Al-Harthi, Roberta McKean-Cowdin, Paolo Gasparini, Ellen W. Demerath, Marco Brumat, Maggie C.Y. Ng, Børge G. Nordestgaard, Kari E. North, Rajiv Chowdhury, Mauno Vanhala, Andrew P. Morris, Sarah E. Medland, Sune F. Nielsen, Ilaria Gandin, Øyvind Helgeland, James P. Cook, Kent D. Taylor, Andrew D. Morris, Gudmar Thorleifsson, André G. Uitterlinden, Pang Yao, Valgerdur Steinthorsdottir, Eric B. Larson, Kerrin S. Small, Cecilia M. Lindgren, Dragana Vuckovic, Mariaelisa Graff, Fotios Drenos, Jaspal S. Kooner
Publikováno v:
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L & Balkau, B & Bang, L E & Corley, J & Davies, G & Deary, I J & Hayward, C & Morris, A D & Pattie, A & Polasek, O & Rudan, I & Starr, J M & Vitart, V 2017, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-41 . https://doi.org/10.1038/s41588-017-0011-x
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L, Balkau, B, Bang, L E, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Lophatananon, A, Morris, A & CHD Exome+ Consortium 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-35 . https://doi.org/10.1038/s41588-017-0011-x
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L, Balkau, B, Bang, L E, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Hammerschlag, A R & Polderman, T J 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-41 . https://doi.org/10.1038/s41588-017-0011-x
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L, Balkau, B, Bang, L E, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Jørgensen, T & CHD Exome+ Consortium 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-41 . https://doi.org/10.1038/s41588-017-0011-x
Grarup, N, Hansen, T, Jørgensen, M E, Lin, L-A, Pedersen, O, Witte, D R, CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, MAGIC Investigators & Understanding Society Scientific Group 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-41 . https://doi.org/10.1038/s41588-017-0011-x
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Kee, F, Hirschhorn, J N & Loos, R J F 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, pp. 26-41 . https://doi.org/10.1038/s41588-017-0011-x
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T N, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L, Balkau, B, Bang, L E, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Böger, C A, Bork-Jensen, J, Bots, M L, Bottinger, E P, Bowden, D W, Brandslund, I, Breen, G, Brilliant, M H, Broer, L, Brumat, M, Burt, A A, Butterworth, A S, Campbell, P T, Cappellani, S, Carey, D J, Catamo, E, Caulfield, M J, Chambers, J C, Chasman, D I, Chen, Y-D I, Chowdhury, R, Christensen, C, Chu, A Y, Cocca, M, Cook, J P, Corley, J, Corominas Galbany, J, Cox, A J, Crosslin, D S, Cuellar-Partida, G, D'Eustacchio, A, Danesh, J, Davies, G, Bakker, P I W, Groot, M C H, Mutsert, R, Deary, I J, Dedoussis, G, Demerath, E W, Heijer, M, Hollander, A I, Ruijter, H M, Dennis, J G, Denny, J C, Angelantonio, E, Drenos, F, du, M, Dubé, M-P, Dunning, A M, Easton, D F, Edwards, T L, Ellinghaus, D, Ellinor, P T, Elliott, P, Evangelou, E, Farmaki, A-E, Farooqi, I S, Faul, J D, Fauser, S, Feng, S, Ferrannini, E, Ferrieres, J, Florez, J C, Ford, I, Fornage, M, Franco, O H, Franke, A, Franks, P W, Friedrich, N, Frikke-Schmidt, R, Galesloot, T E, Gan, W, Gandin, I, Gasparini, P, Gibson, J, Giedraitis, V, Gjesing, A P, Gordon-Larsen, P, Gorski, M, Grabe, H-J R, Grant, S F A, Grarup, N, Griffiths, H L, Grove, M L, Gudnason, V, Gustafsson, S, Haessler, J, Hakonarson, H, Hammerschlag, A R, Hansen, T, Harris, K M, Harris, T B, Hattersley, A T, Have, C T, Hayward, C, He, L, Heard-Costa, N L, Heath, A C, Heid, I M, Helgeland, Ø, Hernesniemi, J, Hewitt, A W, Holmen, O L, Hovingh, G K, Howson, J M M, Hu, Y, Huang, P L, Huffman, J E, Ikram, M A, Ingelsson, E, Jackson, A U, Jansson, J-H K, Jarvik, G P, Jensen, G B, Jia, Y, Johansson, S, Jørgensen, M E, Jørgensen, T, Jukema, J W, Kahali, B, Kahn, R S, Kähönen, M, Kamstrup, P R, Kanoni, S, Kaprio, J, Karaleftheri, M, Kardia, S L R, Karpe, F, Kathiresan, S, Kee, F, Kiemeney, L A, Kim, E, Kitajima, H, Komulainen, P, Kooner, J S, Kooperberg, C, Korhonen, T, Kovacs, P, Kuivaniemi, H, Kutalik, Z, Kuulasmaa, K, Kuusisto, J, Laakso, M, Lakka, T A, Lamparter, D, Lange, E M, Lange, L A, Langenberg, C, Larson, E B, Lee, N R, Lehtimäki, T, Lewis, C E, Li, H, Li, J, Li-Gao, R, Lin, H, Lin, K-H, Lin, L-A, Lin, X, Lind, L, Lindström, J, Linneberg, A, Liu, C-T, Liu, D J, Liu, Y, Lo, K S, Lophatananon, A, Lotery, A J, Loukola, A, Luan, JA, Lubitz, S A, Lyytikäinen, L-P, Männistö, S, Marenne, G, Mazul, A L, McCarthy, M I, McKean-Cowdin, R, Medland, S E, Meidtner, K, Milani, L, Mistry, V, Mitchell, P, Mohlke, K L, Moilanen, L, Moitry, M, Montgomery, G W, Mook-Kanamori, D O, Moore, C, Mori, T A, Morris, A D, Morris, A P, Müller-Nurasyid, M, Munroe, P B, Nalls, M A, Narisu, N, Nelson, C P, Neville, M, Nielsen, S F, Nikus, K, Njølstad, P L R, Nordestgaard, B R G, Nyholt, D R, O'Connel, J R, O'Donoghue, M L, Olde Loohuis, L M, Ophoff, R A, Owen, K R, Packard, C J, Padmanabhan, S, Palmer, C N A, Palmer, N D, Pasterkamp, G, Patel, A P, Pattie, A, Pedersen, O, Peissig, P L, Peloso, G M, Pennell, C E, Perola, M, Perry, J A, Perry, J R B, Pers, T H, Person, T N, Peters, A, Petersen, E R B, Peyser, P A, Pirie, A, Polasek, O, Polderman, T J, Puolijoki, H, Raitakari, O T, Rasheed, A, Rauramaa, R, Reilly, D F, Renström, F, Rheinberger, M, Ridker, P M, Rioux, J D, Rivas, M A, Roberts, D J, Robertson, N R, Robino, A, Rolandsson, O, Rudan, I, Ruth, K S, Saleheen, D, Salomaa, V, Samani, N J, Sapkota, Y, Sattar, N, Schoen, R E, Schreiner, P J, Schulze, M B, Scott, R A, Segura-Lepe, M P, Shah, S H, Sheu, W H-H, Sim, X, Slater, A J, Small, K S, Smith, A V, Southam, L, Spector, T D, Speliotes, E K, Starr, J M, Stefansson, K, Steinthorsdottir, V, Stirrups, K E, Strauch, K, Stringham, H M, Stumvoll, M, Sun, L, Surendran, P, Swift, A J, Tada, H, Tansey, K E, Tardif, J-C, Taylor, K D, Teumer, A, Thompson, D J, Thorleifsson, G, Thorsteinsdottir, U, Thuesen, B H, Tönjes, A, Tromp, G, Trompet, S, Tsafantakis, E, Tuomilehto, J, Tybjaerg-Hansen, A, Tyrer, J P, Uher, R, Uitterlinden, A G, Uusitupa, M, Laan, S W, Duijn, C M, Leeuwen, N, van Setten, J, Vanhala, M, Varbo, A, Varga, T V, Varma, R, Velez Edwards, D R, Vermeulen, S H, Veronesi, G, Vestergaard, H, Vitart, V, Vogt, T F, Völker, U, Vuckovic, D, Wagenknecht, L E, Walker, M, Wallentin, L, Wang, F, Wang, C A, Wang, S, Wang, Y, Ware, E B, Wareham, N J, Warren, H R, Waterworth, D M, Wessel, J, White, H D, Willer, C J, Wilson, J G, Witte, D R, Wood, A R, Wu, Y, Yaghootkar, H, Yao, J, Yao, P, Yerges-Armstrong, L M, Young, R, Zeggini, E, Zhan, X, Zhang, W, Zhao, J H, Zhao, W, Zhou, W, Zondervan, K T, Rotter, J I, Pospisilik, J A, Rivadeneira, F, Borecki, I B, Deloukas, P, Frayling, T M, Lettre, G, North, K E, Lindgren, C M, Hirschhorn, J N & Loos, R J F 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-35 . https://doi.org/10.1038/s41588-017-0011-x
Nature Genetics, 50(1), 26. Nature Publishing Group
Nature Genetics
Nat. Genet. 50, 26-41 (2018)
Nature genetics, 50(1), 26-41. Nature Publishing Group
Nature Genetics, 50(1), 26-41. Nature Publishing Group
Nature genetics, vol. 50, no. 1, pp. 26-41
Nature Genetics, 50(1), 26
NATURE GENETICS
Nature genetics 50(1), 26-41 (2017). doi:10.1038/s41588-017-0011-x
Nature Genetics, 50, 26-41
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L, Balkau, B, Bang, L E, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, L F, Brandslund, I, Christensen, C, Jensen, G B, Jørgensen, M E, Thuesen, B H & CHD Exome+ Consortium 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-41 . https://doi.org/10.1038/s41588-018-0050-y
Nature Genetics, 50(1), 26-35. Nature Publishing Group
Nature Genetics, 50, 1, pp. 26-41
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L, Balkau, B, Bang, L E, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Lophatananon, A, Morris, A & CHD Exome+ Consortium 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-35 . https://doi.org/10.1038/s41588-017-0011-x
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L, Balkau, B, Bang, L E, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Hammerschlag, A R & Polderman, T J 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-41 . https://doi.org/10.1038/s41588-017-0011-x
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L, Balkau, B, Bang, L E, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Jørgensen, T & CHD Exome+ Consortium 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-41 . https://doi.org/10.1038/s41588-017-0011-x
Grarup, N, Hansen, T, Jørgensen, M E, Lin, L-A, Pedersen, O, Witte, D R, CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, MAGIC Investigators & Understanding Society Scientific Group 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-41 . https://doi.org/10.1038/s41588-017-0011-x
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Kee, F, Hirschhorn, J N & Loos, R J F 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, pp. 26-41 . https://doi.org/10.1038/s41588-017-0011-x
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T N, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L, Balkau, B, Bang, L E, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Böger, C A, Bork-Jensen, J, Bots, M L, Bottinger, E P, Bowden, D W, Brandslund, I, Breen, G, Brilliant, M H, Broer, L, Brumat, M, Burt, A A, Butterworth, A S, Campbell, P T, Cappellani, S, Carey, D J, Catamo, E, Caulfield, M J, Chambers, J C, Chasman, D I, Chen, Y-D I, Chowdhury, R, Christensen, C, Chu, A Y, Cocca, M, Cook, J P, Corley, J, Corominas Galbany, J, Cox, A J, Crosslin, D S, Cuellar-Partida, G, D'Eustacchio, A, Danesh, J, Davies, G, Bakker, P I W, Groot, M C H, Mutsert, R, Deary, I J, Dedoussis, G, Demerath, E W, Heijer, M, Hollander, A I, Ruijter, H M, Dennis, J G, Denny, J C, Angelantonio, E, Drenos, F, du, M, Dubé, M-P, Dunning, A M, Easton, D F, Edwards, T L, Ellinghaus, D, Ellinor, P T, Elliott, P, Evangelou, E, Farmaki, A-E, Farooqi, I S, Faul, J D, Fauser, S, Feng, S, Ferrannini, E, Ferrieres, J, Florez, J C, Ford, I, Fornage, M, Franco, O H, Franke, A, Franks, P W, Friedrich, N, Frikke-Schmidt, R, Galesloot, T E, Gan, W, Gandin, I, Gasparini, P, Gibson, J, Giedraitis, V, Gjesing, A P, Gordon-Larsen, P, Gorski, M, Grabe, H-J R, Grant, S F A, Grarup, N, Griffiths, H L, Grove, M L, Gudnason, V, Gustafsson, S, Haessler, J, Hakonarson, H, Hammerschlag, A R, Hansen, T, Harris, K M, Harris, T B, Hattersley, A T, Have, C T, Hayward, C, He, L, Heard-Costa, N L, Heath, A C, Heid, I M, Helgeland, Ø, Hernesniemi, J, Hewitt, A W, Holmen, O L, Hovingh, G K, Howson, J M M, Hu, Y, Huang, P L, Huffman, J E, Ikram, M A, Ingelsson, E, Jackson, A U, Jansson, J-H K, Jarvik, G P, Jensen, G B, Jia, Y, Johansson, S, Jørgensen, M E, Jørgensen, T, Jukema, J W, Kahali, B, Kahn, R S, Kähönen, M, Kamstrup, P R, Kanoni, S, Kaprio, J, Karaleftheri, M, Kardia, S L R, Karpe, F, Kathiresan, S, Kee, F, Kiemeney, L A, Kim, E, Kitajima, H, Komulainen, P, Kooner, J S, Kooperberg, C, Korhonen, T, Kovacs, P, Kuivaniemi, H, Kutalik, Z, Kuulasmaa, K, Kuusisto, J, Laakso, M, Lakka, T A, Lamparter, D, Lange, E M, Lange, L A, Langenberg, C, Larson, E B, Lee, N R, Lehtimäki, T, Lewis, C E, Li, H, Li, J, Li-Gao, R, Lin, H, Lin, K-H, Lin, L-A, Lin, X, Lind, L, Lindström, J, Linneberg, A, Liu, C-T, Liu, D J, Liu, Y, Lo, K S, Lophatananon, A, Lotery, A J, Loukola, A, Luan, JA, Lubitz, S A, Lyytikäinen, L-P, Männistö, S, Marenne, G, Mazul, A L, McCarthy, M I, McKean-Cowdin, R, Medland, S E, Meidtner, K, Milani, L, Mistry, V, Mitchell, P, Mohlke, K L, Moilanen, L, Moitry, M, Montgomery, G W, Mook-Kanamori, D O, Moore, C, Mori, T A, Morris, A D, Morris, A P, Müller-Nurasyid, M, Munroe, P B, Nalls, M A, Narisu, N, Nelson, C P, Neville, M, Nielsen, S F, Nikus, K, Njølstad, P L R, Nordestgaard, B R G, Nyholt, D R, O'Connel, J R, O'Donoghue, M L, Olde Loohuis, L M, Ophoff, R A, Owen, K R, Packard, C J, Padmanabhan, S, Palmer, C N A, Palmer, N D, Pasterkamp, G, Patel, A P, Pattie, A, Pedersen, O, Peissig, P L, Peloso, G M, Pennell, C E, Perola, M, Perry, J A, Perry, J R B, Pers, T H, Person, T N, Peters, A, Petersen, E R B, Peyser, P A, Pirie, A, Polasek, O, Polderman, T J, Puolijoki, H, Raitakari, O T, Rasheed, A, Rauramaa, R, Reilly, D F, Renström, F, Rheinberger, M, Ridker, P M, Rioux, J D, Rivas, M A, Roberts, D J, Robertson, N R, Robino, A, Rolandsson, O, Rudan, I, Ruth, K S, Saleheen, D, Salomaa, V, Samani, N J, Sapkota, Y, Sattar, N, Schoen, R E, Schreiner, P J, Schulze, M B, Scott, R A, Segura-Lepe, M P, Shah, S H, Sheu, W H-H, Sim, X, Slater, A J, Small, K S, Smith, A V, Southam, L, Spector, T D, Speliotes, E K, Starr, J M, Stefansson, K, Steinthorsdottir, V, Stirrups, K E, Strauch, K, Stringham, H M, Stumvoll, M, Sun, L, Surendran, P, Swift, A J, Tada, H, Tansey, K E, Tardif, J-C, Taylor, K D, Teumer, A, Thompson, D J, Thorleifsson, G, Thorsteinsdottir, U, Thuesen, B H, Tönjes, A, Tromp, G, Trompet, S, Tsafantakis, E, Tuomilehto, J, Tybjaerg-Hansen, A, Tyrer, J P, Uher, R, Uitterlinden, A G, Uusitupa, M, Laan, S W, Duijn, C M, Leeuwen, N, van Setten, J, Vanhala, M, Varbo, A, Varga, T V, Varma, R, Velez Edwards, D R, Vermeulen, S H, Veronesi, G, Vestergaard, H, Vitart, V, Vogt, T F, Völker, U, Vuckovic, D, Wagenknecht, L E, Walker, M, Wallentin, L, Wang, F, Wang, C A, Wang, S, Wang, Y, Ware, E B, Wareham, N J, Warren, H R, Waterworth, D M, Wessel, J, White, H D, Willer, C J, Wilson, J G, Witte, D R, Wood, A R, Wu, Y, Yaghootkar, H, Yao, J, Yao, P, Yerges-Armstrong, L M, Young, R, Zeggini, E, Zhan, X, Zhang, W, Zhao, J H, Zhao, W, Zhou, W, Zondervan, K T, Rotter, J I, Pospisilik, J A, Rivadeneira, F, Borecki, I B, Deloukas, P, Frayling, T M, Lettre, G, North, K E, Lindgren, C M, Hirschhorn, J N & Loos, R J F 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-35 . https://doi.org/10.1038/s41588-017-0011-x
Nature Genetics, 50(1), 26. Nature Publishing Group
Nature Genetics
Nat. Genet. 50, 26-41 (2018)
Nature genetics, 50(1), 26-41. Nature Publishing Group
Nature Genetics, 50(1), 26-41. Nature Publishing Group
Nature genetics, vol. 50, no. 1, pp. 26-41
Nature Genetics, 50(1), 26
NATURE GENETICS
Nature genetics 50(1), 26-41 (2017). doi:10.1038/s41588-017-0011-x
Nature Genetics, 50, 26-41
Turcot, V, Lu, Y, Highland, H M, Schurmann, C, Justice, A E, Fine, R S, Bradfield, J P, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, A E, Karaderi, T, Lempradl, A, Locke, A E, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, K L, Alfred, T, Feitosa, M F, Masca, N G D, Manning, A K, Medina-Gomez, C, Mudgal, P, Ng, M C Y, Reiner, A P, Vedantam, S, Willems, S M, Winkler, T W, Abecasis, G, Aben, K K, Alam, D S, Alharthi, S E, Allison, M, Amouyel, P, Asselbergs, F W, Auer, P L, Balkau, B, Bang, L E, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, L F, Brandslund, I, Christensen, C, Jensen, G B, Jørgensen, M E, Thuesen, B H & CHD Exome+ Consortium 2018, ' Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity ', Nature Genetics, vol. 50, no. 1, pp. 26-41 . https://doi.org/10.1038/s41588-018-0050-y
Nature Genetics, 50(1), 26-35. Nature Publishing Group
Nature Genetics, 50, 1, pp. 26-41
Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains
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https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247d0a0f65cfe65a4234fc1f8f72fc1d
https://doi.org/10.1038/s41588-017-0011-x
https://doi.org/10.1038/s41588-017-0011-x