Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Yang, Ge"'
Publikováno v:
Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 21, Iss, Pp 87-97 (2021)
Molecular Therapy: Oncolytics, Vol 21, Iss, Pp 87-97 (2021)
Although oxaliplatin is an effective chemotherapeutic drug commonly used for colorectal cancer (CRC) treatment, drug resistance usually occurs during the long-term use of it. It is urgent to create strategies to reduce the resistance of CRC cells to
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 123:721-726
The objective of this study was to evaluate the effect of apatinib on the pharmacokinetics of venlafaxine and O-desmethylvenlafaxine in SD rats and the inhibitory effects of apatinib on venlafaxine in rat and human liver microsomes. Twenty-one SD mal
Autor:
Shijie Song, Yang Ge, Kexin Liu, Qiang Meng, Jianbin Zhang, Xiaodong Ma, Xiuli Sun, Changyuan Wang, Yongming Li, Jiaxin Huang, Zhihao Liu, Jihong Yao
Publikováno v:
European Journal of Medicinal Chemistry. 143:1847-1857
The BTK and JAK3 receptor tyrosine kinases are two validated and therapeutically amenable targets in the treatment of B-cell lymphomas. Here we report the identification of several classes of pyrimidine derivatives as potent BTK and JAK3 dual inhibit
Autor:
Yang Ge, Kexin Liu, Jianbin Zhang, Yanxia Li, Qiang Meng, Song Anran, Jinyong Peng, Xiaodong Ma, Changyuan Wang, Zeyao Tang
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:2724-2729
With the aim to overcome the drug resistance induced by the EGFR T790M mutation (EGFRT790M), herein, a family of diphenylpyrimidine derivatives (Sty-DPPYs) bearing a C-2 (E)-4-(styryl)aniline functionality were designed and synthesized as potential E
Autor:
Stefan Rupf, Lei Cheng, Haohao Wang, Qian Li, Michael D. Weir, Matthias Hannig, Xuedong Zhou, Yang Ge, Keke Zhang, Hockin H.K. Xu, Suping Wang
Publikováno v:
International Journal of Oral Science
Dental restorative materials with antimicrobial properties can inhibit bacterial colonization, which may result in a reduction of caries at tooth-filling interaction zones. This study aimed to develop antibacterial glass–ionomer cements (GIC) conta
Publikováno v:
Biomedicine & Pharmacotherapy. 78:156-164
Background Islet transplantation is a commonly therapeutic strategy for diabetes mellitus. However, avascular phase and the poor formation of blood vessels in the late period lead to islet allograft loss which contributed to inefficiency and short-ac
Autor:
Minggang Yang, Yang Ge, Mingyun Li, Michael D. Weir, Biao Ren, Lei Cheng, Jing Chen, Xian Peng, Bolei Li, Yao Wu, Xuedong Zhou, Mingye Feng, Hockin H.K. Xu
Publikováno v:
Molecules, Vol 22, Iss 11, p 2013 (2017)
Molecules; Volume 22; Issue 11; Pages: 2013
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules; Volume 22; Issue 11; Pages: 2013
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
The effects of dimethylaminododecyl methacrylate (DMADDM) modified titanium implants on bacterial activity and microbial ecosystem of saliva-derived biofilm were investigated for the first time. Titanium discs were coated with DMADDM solutions at mas
Autor:
Yang Ge, Xuedong Zhou, Michael D. Weir, Hockin H.K. Xu, Suping Wang, Lei Cheng, Biao Ren, Mingye Feng, Mingyun Li
Publikováno v:
Materials, Vol 10, Iss 1, p 26 (2017)
Materials; Volume 10; Issue 1; Pages: 26
Materials
Materials; Volume 10; Issue 1; Pages: 26
Materials
The mechanical properties and anti-caries effect of a novel anti-caries adhesive containing poly (amidoamine) dendrimer (PAMAM) and dimethylaminododecyl methacrylate (DMADDM) were investigated for the first time. Microtensile bond strength and surfac
Autor:
Shida Wang, Mingyun Li, Xin Xu, Yang Ge, Xuedong Zhou, Keke Zhang, Lei Cheng, Yuqing Li, Suping Wang, Michael D. Weir, Ning Xu, Hockin H.K. Xu
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 7, Pp 12791-12806 (2014)
International Journal of Molecular Sciences; Volume 15; Issue 7; Pages: 12791-12806
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 15; Issue 7; Pages: 12791-12806
International Journal of Molecular Sciences
Antibacterial bonding agents and composites containing dimethylaminododecyl methacrylate (DMADDM) have been recently developed. The objectives of this study were to investigate the antibacterial effect of novel adhesives containing different mass fra
Autor:
Yang Ge, Kexin Liu, Yue Jin, Zhendong Song, Jinyong Peng, Yanxia Li, Changyuan Wang, Xiaodong Ma, Jianbin Zhang, Zeyao Tang
Publikováno v:
Bioorganicmedicinal chemistry. 24(21)
A series of novel azole-diphenylpyrimidine derivatives (AzDPPYs) were synthesized and biologically evaluated as potent EGFRT790M inhibitors. Among these analogues, the most active inhibitor 6e not only displayed high activity against EGFRT790M/L858R