Zobrazeno 1 - 10
of 9 248
pro vyhledávání: '"Lipids"'
Autor:
Christina Voelkel-Johnson
Publikováno v:
Semin Cancer Biol
The aberrant biology of polyploid giant cancer cells (PGCC) includes dysregulation of the cell cycle, induction of stress responses, and dedifferentiation, all of which are likely accompanied by adaptations in biophysical properties and metabolic act
Autor:
Augustine M.K. Choi, Mi-Ae Park, Mijin Yun, Chun K. Kim, Kiichi Nakahira, Jong Seok Moon, Maria Haslip, Ilias I. Siempos, Judie A. Howrylak, Patty J. Lee, Seonmin Lee, Stefan W. Ryter
Publikováno v:
Journal of Clinical Investigation. 133
Cellular lipid metabolism has been linked to immune responses; however, the precise mechanisms by which de novo fatty acid synthesis can regulate inflammatory responses remain unclear. The NLRP3 inflammasome serves as a platform for caspase-1–depen
Publikováno v:
Glycoconjugate Journal. 39:55-74
Parkinson's disease (PD) is a neurodegenerative disorder that affects over 10 million aging people worldwide. This condition is characterized by the degeneration of dopaminergic neurons in the pars compacta region of the substantia nigra (SNpc) and b
Publikováno v:
J Invest Dermatol
Autoimmunity results from the breaking of immune tolerance, leading to inflammation and pathology. Although well studied in the conventional T-cell field, the role of nonconventional T cells in autoimmunity is less understood. CD1-restricted T cells
Autor:
Wenxuan Zhang, Rachel E. Thomas, Johan W. Jonker, Justina C. Wolters, Fentaw Abegaz, Janine K. Kruit, Ronald van Os, Marleen B Dommerholt, Barbara M. Bakker, Dirk-Jan Reijngoud, Maaike Blankestijn, Ydwine T. van der Veen, Marcel A. Vieira-Lara, Albert Gerding
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-18 (2021)
BMC Biology, 19(1):154. BioMed Central Ltd.
BMC Biology
Vieira-Lara, M A, Dommerholt, M B, Zhang, W, Blankestijn, M, Wolters, J C, Abegaz, F, Gerding, A, van der Veen, Y T, Thomas, R, van Os, R P, Reijngoud, D J, Jonker, J W, Kruit, J K & Bakker, B M 2021, ' Age-related susceptibility to insulin resistance arises from a combination of CPT1B decline and lipid overload ', BMC Biology, vol. 19, no. 1, 154 . https://doi.org/10.1186/s12915-021-01082-5
BMC Biology, 19(1):154. BioMed Central Ltd.
BMC Biology
Vieira-Lara, M A, Dommerholt, M B, Zhang, W, Blankestijn, M, Wolters, J C, Abegaz, F, Gerding, A, van der Veen, Y T, Thomas, R, van Os, R P, Reijngoud, D J, Jonker, J W, Kruit, J K & Bakker, B M 2021, ' Age-related susceptibility to insulin resistance arises from a combination of CPT1B decline and lipid overload ', BMC Biology, vol. 19, no. 1, 154 . https://doi.org/10.1186/s12915-021-01082-5
Background The skeletal muscle plays a central role in glucose homeostasis through the uptake of glucose from the extracellular medium in response to insulin. A number of factors are known to disrupt the normal response to insulin leading to the emer
Publikováno v:
Traffic (Copenhagen, Denmark)
Exosomes are extracellular vesicles that in recent years have received special attention for their regulatory functions in numerous biological processes. Recent evidence suggests a correlation between the composition of exosomes in body fluids and th
Publikováno v:
Biochemical and Biophysical Research Communications. 558:114-119
The CH2 domain is a critical element of the human Immunoglobulin G (IgG) constant region. Although the CH2 domain is the least stable domain in IgG, it is also a promising scaffold candidate for developing novel therapeutic approaches. Recently, we s
Autor:
Mia Furgurson, Ayrea Hurley, Jun Han, Alexandria M. Doerfler, Ang Li, Jason C. Burton, Christoph H. Borchers, Marco De Giorgi, William R. Lagor, Rachel H. Hsu, Kalyani R. Patel, Kelsey E Jarrett
Publikováno v:
J Lipid Res
Journal of Lipid Research, Vol 61, Iss 12, Pp 1675-1686 (2020)
Journal of Lipid Research, Vol 61, Iss 12, Pp 1675-1686 (2020)
HMG-CoA reductase (Hmgcr) is the rate-limiting enzyme in the mevalonate pathway and is inhibited by statins. In addition to cholesterol, Hmgcr activity is also required for synthesizing nonsterol isoprenoids, such as dolichol, ubiquinone, and farnesy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770616831edb479aac432495d2555db3
Endothelial progenitor cells (EPCs) promote angiogenesis and play an important role in myocardial and vascular repair after ischemia and infarction. EPCs consist of different subpopulations including CD34‑CD133+ EPCs, which are precursors of more m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa3e7b06dce8ad408e9f6577c062b5e
Autor:
Gui-qiong Huang, Zhang-Bin Tan, Hong-Mei Chen, Hui-Jie Fan, Ling-Peng Xie, Bin Liu, Yu-Ting Wu, Guanghong Chen, Ying-Chun Zhou, Min Liu, Hong-Lin Xu
Publikováno v:
Journal of Ginseng Research, Vol 46, Iss 1, Pp 156-166 (2022)
Journal of Ginseng Research
Journal of Ginseng Research
Background Panax ginseng Meyer (P. ginseng), a herb distributed in Korea, China and Japan, exerts benefits on diverse inflammatory conditions. However, the underlying mechanism and active ingredients remains largely unclear. Herein, we aimed to explo