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MicroRNAs (miRNAs) crucially modulate fundamental biologic processes such as angiogenesis. In the present study, we focused on the molecular function of miRNA-370-3p (miR-370) in regulating the angiogenic activity of endothelial cells (ECs). Transfec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21aa23e93d80c91eef5d69c1fda31721
Autor:
Nivetha Sarah Ebenezer, Jawed A. Siddiqui, Mohd W. Nasser, Imayavaramban Lakshmanan, Ravi Salgia, Surinder K. Batra, Shailendra Kumar Maurya, Parvez Khan
Publikováno v:
Semin Cell Dev Biol
The process of cancer initiation and development is a dynamic and complex mechanism involving multiple genetic and non-genetic variations. With the development of high throughput techniques like next-generation sequencing, the field of cancer biology
Publikováno v:
Biopreservation and Biobanking. 20:31-37
Freeze-drying is one of the sperm preservation methods leading to the long-term preservation of sperm genetic material. Our main goal of this study was to evaluate the effect of the trehalose freeze-drying method on sperm motility, viability, morphol
An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth
Autor:
Ulrike Kusebauch, Zhanqi Liu, Matthias Ernst, Shahin Rafii, Martin Lackmann, Andrew M. Scott, Lakmali Atapattu, Katja Horvay, Linda Hii, Moritz F. Eissman, Dimitar B. Nikolov, Chanly Chheang, Zhongwei Cao, Helen E. Abud, Bi-Sen Ding, Kai Xu, Nayanendu Saha, Carmen Llerena, Robert L. Moritz, Mary E. Vail, Peter W. Janes
Publikováno v:
The Journal of Experimental Medicine
Janes et al. developed an anti-ADAM10 mAb (8C7) that binds to an active form of ADAM10 present in tumors, particularly in stem-like cells. Administration of 8C7 inhibits Notch activity and tumor growth in mouse models, including regrowth after chemot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf5e1be2a19ef93692b5afad9f2f905
Autor:
Maria E. Teves, Eduardo R. S. Roldan
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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The spermatozoon is a highly differentiated and polarized cell, with two main structures: the head, containing a haploid nucleus and the acrosomal exocytotic granule, and the flagellum, which generates energy and propels the cell; both structures are
Publikováno v:
Seminars in Cell & Developmental Biology. 121:114-124
Varicoceles are dilated veins within the spermatic cord and a relatively common occurrence in men. Fortunately, the large majority of men are asymptomatic, however, a proportion of men with varicoceles can suffer from infertility and testosterone def
Autor:
William H. Walker
Publikováno v:
Semin Cell Dev Biol
Male fertility requires the continual production of sperm by the process of spermatogenesis. This process requires the correct timing of regulatory signals to germ cells during each phase of their development. MicroRNAs (miRNAs) in germ cells and sup
Publikováno v:
Seminars in Cell & Developmental Biology. 121:10-23
Sertoli cells (SCs) are immune privileged cells found in the testis that function to immunologically protect maturing germ cells from immune destruction. This immune protection is due to the blood-testis-barrier, which prevents infiltration of cytoto
Publikováno v:
Seminars in Cell & Developmental Biology. 121:63-70
Stem cells are specialized cells that can renew themselves through cell division and can differentiate into multi-lineage cells. Mesenchymal stem cells are adult stem cells that exist in animal and human tissues. Mesenchymal stem cells have the abili
Publikováno v:
American Journal of Physiology-Cell Physiology. 322:C94-C110
Following anabolic stimuli (mechanical loading and/or amino acid provision), the mechanistic target of rapamycin complex 1 (mTORC1), a master regulator of protein synthesis, translocates toward the cell periphery. However, it is unknown if mTORC1-med