Zobrazeno 31 - 40
of 32 177
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Autor:
Daniel Pérez-Cremades, A.K.M. Khyrul Wara, Stefan Haemmig, Yihuan Deng, Qiuyan Dai, Eugenia Shvartz, Viorel Simion, Galina K. Sukhova, Dafeng Yang, Huaner Ni, Carmel Assa, Rulin Zhuang, Mark W. Feinberg, Jingshu Chen, Grasiele Sausen, Henry S. Cheng
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Vascular smooth muscle cell (VSMC) plasticity plays a critical role in the development of atherosclerosis. Long noncoding RNAs (lncRNAs) are emerging as important regulators in the vessel wall and impact cellular function through diverse i
Autor:
Xiao Qian Chen, Shang Bin Yu, Song Lin Yin, Guo Qiang Liu, Feng Hu, Feng Liu, Chun Yang Li, Xiao Hong Xu, Ting Ting Zhang
Publikováno v:
Biochemical and Biophysical Research Communications. 569:1-9
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor without curable therapy. Surgical resection remains the first choice of patients with GBM but tumors relapse rapidly even combined with conventional chemoradiotherapy. The
Autor:
Samantha L. Sampson, Gerhard Walzl, Brandon Anton Paarwater, Jane A. Shaw, Leigh A. Kotze, Jomien Mouton, Stephanus T. Malherbe, Nelita du Plessis
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 321:L566-L575
The influence of smoke-derived or air pollution-derived cytoplasmic particulate matter (PM) can be detrimental and can lead to failed lung immunity. We investigated mycobacterial uptake, intracellular replication, and soluble immune-mediator response
Autor:
Ling Zhang, Parirokh Awasthi, Zine-Eddine Kherraf, Zhibing Zhang, Ven Natarajan, Yitian Yap, Wei Li, Bo Hu, Pancharatnam Jeyasuria, Pierre F. Ray, Qian Huang, Rex A. Hess, Caroline Cazin, James G. Granneman, Ljiljana Mladenovic-Lucas, Qi Zhou
Publikováno v:
Dev Biol
Intraflagellar transport (IFT) is an evolutionarily conserved mechanism essential for the assembly and maintenance of most eukaryotic cilia and flagella, including mammalian sperm tails. Depletion of IFT27, a component of the IFT complex, in male ger
Autor:
Christopher P. Chaney, Thomas L. Carroll, Anne R. Ryan, Ashwani Kumar Gupta, Alicia R. England, Max Hiltabidle, Leif Oxburgh, Ondine Cleaver, Mitzy A. Cowdin, Edward Daniel
Publikováno v:
Dev Biol
Chronic kidney disease (CKD) and end stage renal disease (ESRD) are increasingly frequent and devastating conditions that have driven a surge in the need for kidney transplantation. A stark shortage of organs has fueled interest in generating viable
CAR- and TRuC-redirected regulatory T cells differ in capacity to control adaptive immunity to FVIII
Autor:
Jyoti Rana, Sandeep R. P. Kumar, Todd M. Brusko, Rania Saboungi, Moanaro Biswas, Maite Muñoz-Melero, Daniel J. Perry
Publikováno v:
Molecular Therapy. 29:2660-2676
Regulatory T cells (Tregs) control immune responses in autoimmune disease, transplantation, and enable antigen-specific tolerance induction in protein-replacement therapies. Tregs can exert a broad array of suppressive functions through their T cell
Autor:
Vincent Prevot, Michael D Culler, Éva Rumpler, András Matolcsy, Gábor Szabó, Csaba Vastagh, Erik Hrabovszky, Viktória Váczi, Miklós Sárvári, Szilárd Póliska, Cecile Allet, Imre Farkas, Gergely Rácz, Paolo Giacobini, Norbert Solymosi, Balázs Göcz, Szabolcs Takács, Katalin Skrapits, Ferenc Erdélyi, Blanka Tóth, Ludovica Cotellessa
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Human reproduction is controlled by ∼2,000 hypothalamic gonadotropin-releasing hormone (GnRH) neurons. Here we report the discovery and characterization of additional 150-200,000 GnRH-synthesizing cells in the human basal ganglia and basal forebrai
Autor:
Nikola Šutulović, Nela Puškaš, Olivera Stanojlović, Djurdja Jerotic, Djuro Macut, Dragan Hrnčić, Sonja Suvakov, Aleksandra Rašić-Marković, Tatjana Simic, Željko Grubač
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Sleep architecture alterations, among which sleep fragmentation is highly prevalent, represent risk factors for a variety of diseases, ranging from cardiovascular to brain disorders, including anxiety. What mediates anxiety occurrence upon sleep frag
The inflammatory role of dysregulated IRS2 in pulmonary vascular remodeling under hypoxic conditions
Autor:
Qing Lin, Homare Ito, Achsah D. Keegan, Kazuyo Yamaji-Kegan, Roger A. Johns, Rasa Tamosiuniene, John Skinner, Mark R. Nicolls, Mayumi Nakahara
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Pulmonary hypertension (PH) is a devastating disease characterized by progressive elevation of pulmonary vascular resistance, right ventricular failure, and ultimately death. We have shown previously that insulin receptor substrate 2 (IRS2), a molecu
Autor:
Tadayoshi Okimoto, Takahiro Hiratsuka, Shusaku Kurogi, Masafumi Inomata, Tomohisa Uchida, Daisuke Kakisako, Teijiro Hirashita, Masatsugu Moriyama, Chisato Nakada, Yoshiyuki Tsukamoto, Naoki Hijiya, Yuka Hirashita, Tsuyoshi Etoh, Tomonori Akagi, Masaaki Kodama, Yoshitake Ueda, Kazuhiro Mizukami, Yoko Kudo, Koichi Honda, Kazunari Murakami, Hidefumi Shiroshita
Publikováno v:
Laboratory Investigation. 101:1036-1047
Mutations in RAS or BRAF are associated with poor prognosis and resistance to epidermal growth factor receptor (EGFR)-targeted therapy in colorectal cancer (CRC). Despite their common ability to activate downstream genes such as MEK and ERK, the ther