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Autor:
Maria E. Teves, Eduardo R. S. Roldan
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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The spermatozoon is a highly differentiated and polarized cell, with two main structures: the head, containing a haploid nucleus and the acrosomal exocytotic granule, and the flagellum, which generates energy and propels the cell; both structures are
Publikováno v:
Seminars in Cell & Developmental Biology. 121:114-124
Varicoceles are dilated veins within the spermatic cord and a relatively common occurrence in men. Fortunately, the large majority of men are asymptomatic, however, a proportion of men with varicoceles can suffer from infertility and testosterone def
Autor:
William H. Walker
Publikováno v:
Semin Cell Dev Biol
Male fertility requires the continual production of sperm by the process of spermatogenesis. This process requires the correct timing of regulatory signals to germ cells during each phase of their development. MicroRNAs (miRNAs) in germ cells and sup
Publikováno v:
Seminars in Cell & Developmental Biology. 121:10-23
Sertoli cells (SCs) are immune privileged cells found in the testis that function to immunologically protect maturing germ cells from immune destruction. This immune protection is due to the blood-testis-barrier, which prevents infiltration of cytoto
Publikováno v:
American Journal of Physiology-Cell Physiology. 322:C94-C110
Following anabolic stimuli (mechanical loading and/or amino acid provision), the mechanistic target of rapamycin complex 1 (mTORC1), a master regulator of protein synthesis, translocates toward the cell periphery. However, it is unknown if mTORC1-med
Autor:
C. Yan Cheng, Chris K C Wong, Xiaolong Wu, Lingling Wang, Adolfo Perrotta, Bruno Silvestrini, Fei Sun, Linxi Li
Publikováno v:
Seminars in Cell & Developmental Biology. 121:53-62
In rodents and humans, the major cellular events at spermatogenesis include self-renewal of spermatogonial stem cells and undifferentiated spermatogonia via mitosis, commitment of spermatogonia to differentiation and transformation to spermatocytes,
Autor:
Matthias Titeux, David Michonneau, Nicolas Pallet, Armance Marchal, Soëli Charbonnier, Juliette Leon, Julien Zuber, Katrin Vogt, Marianne Delville, Hélène Vinçon, Ivan Nemazanyy, Isabelle André, Jean-Luc Taupin, Christophe Legendre, Birgit Sawitzki, Tifanie Blein, Marina Cavazzana, Dany Anglicheau, Sylvain Latour, Baptiste Lamarthée, Lucas Rabaux, Emmanuelle Six, Emmanuel Martin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-26844-1⟩
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-021-26844-1⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-26844-1⟩
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-021-26844-1⟩
The use of chimeric antigen receptor (CAR)-engineered regulatory T cells (Tregs) has emerged as a promising strategy to promote immune tolerance. However, in conventional T cells (Tconvs), CAR expression is often associated with tonic signaling, whic
Autor:
Ghanem, Mada, Homps-Legrand, Méline, Garnier, Marc, Morer, Lise, Goletto, Tiphaine, Frija-Masson, Justine, Wicky, Paul-Henri, Jaquet, Pierre, Bancal, Catherine, Hurtado-Nedelec, Margarita, de Chaisemartin, Luc, Jaillet, Madeleine, Mailleux, Arnaud, Quesnel, Christophe, Poté, Nicolas, Debray, Marie-Pierre, de Montmollin, Etienne, Neukirch, Catherine, Borie, Raphael, Taillé, Camille, Crestani, Bruno, Covid Cohort Study Group, French, Andréjak, Claire
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 2021, 321 (5), pp.L847-L858. ⟨10.1152/ajplung.00105.2021⟩
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2021, 321 (5), pp.L847-L858. ⟨10.1152/ajplung.00105.2021⟩
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 2021, 321 (5), pp.L847-L858. ⟨10.1152/ajplung.00105.2021⟩
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2021, 321 (5), pp.L847-L858. ⟨10.1152/ajplung.00105.2021⟩
Increased blood fibrocytes are associated with a poor prognosis in fibrotic lung diseases. We aimed to determine whether the percentage of circulating fibrocytes could be predictive of severity and prognosis during coronavirus disease 2019 (COVID-19)
Autor:
Wataru Morozumi, Yuki Iwata, Hideaki Hara, Masamitsu Shimazawa, Shinsuke Nakamura, Kota Aoshima, Satoshi Inagaki
Publikováno v:
Journal of Pharmacological Sciences, Vol 147, Iss 2, Pp 211-221 (2021)
Trabecular meshwork (TM) regulates the intraocular pressure (IOP) through the control of aqueous humor outflow. Previous reports show that TM cells express 11 types of mechanosensitive molecules, including Piezo 1, which sense mechanical stimuli. How
Autor:
Rachel Warren, Gloria S. Pryhuber, Andrew M. Dylag, Jeannie Haak, Min Yee, Michael A. O'Reilly
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
It is well known that supplemental oxygen used to treat preterm infants in respiratory distress is associated with permanently disrupting lung development and the host response to influenza A virus (IAV). However, many infants who go home with normal