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Autor:
Chia-Chun Chang, Li-Ying Sung, Christopher L. Antos, Min Peng, Luis Eduardo Coelho Andrade, Gerson Dierley Keppeke, Ji-Long Liu
Publikováno v:
Developmental Biology. 478:89-101
Inosine monophosphate dehydrogenase (IMPDH) catalyzes the rate-limiting step in de novo guanine nucleotide biosynthesis. Its activity is negatively regulated by the binding of GTP. IMPDH can form a membraneless subcellular structure termed the cytoop
Publikováno v:
Biochemical and Biophysical Research Communications. 567:125-130
Differentiated mammary epithelial cells are responsible for milk synthesis during lactation, supporting early postnatal life in mammals. These cells are found in the terminal alveoli of a secretory epithelium, which is surrounded by myoepithelial cel
Publikováno v:
Molecular Biology of the Cell
Loss-of-function analysis is one of the major arsenals we have for understanding gene functions in mammalian cells. For analysis of essential genes, the major challenge is to develop simple methodologies for tight and rapid inducible gene inactivatio
Publikováno v:
Clinical and Experimental Nephrology. 25:1182-1192
Tubular injury plays a crucial role in the pathogenesis of diabetic nephropathy (DN). It is well known that many microRNAs (miRNAs) exert crucial effects on tubular injury. This study intends to explore the effect of miR-142-3p on the apoptosis and o
Autor:
Laura Payán-Bravo, Esther Lara, Sara Fontalva, Yosu Odriozola-Gil, Sebastián Chávez, Silvia Jimeno-González, Ildefonso Cases, Carles Suñé, Yerma Pareja-Sanchez, José Antonio Guerrero-Martínez, Xenia Peñate, Jose C. Reyes, Mari Cruz Muñoz-Centeno
Publikováno v:
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Nucleic Acids Research
instname
Digital.CSIC. Repositorio Institucional del CSIC
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Nucleic Acids Research
Prefoldin is a heterohexameric complex conserved from archaea to humans that plays a cochaperone role during the co-translational folding of actin and tubulin monomers. Additional functions of prefoldin have been described, including a positive contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca2dd77cba67057550c36122010a247
http://hdl.handle.net/10261/309906
http://hdl.handle.net/10261/309906
Publikováno v:
Journal of Cellular Biochemistry
WNT5A activates noncanonical Wnt signaling pathways and has critical functions in early development, differentiation, and tissue homeostasis. Two major WNT5A protein isoforms, which in this study we term WNT5A‐L(A) and WNT5A‐S(B), have been ident
Autor:
Aharon Nachshon, Michal Schwartz, Yoav Lubelsky, Hadas Tamir, Tal Fisher, Roni Winkler, Batsheva Rozman, Orel Mizrahi, Yfat Yahalom-Ronen, Nir Paran, Igor Ulitsky, Yaara Finkel, Boris Slobodin, Binyamin Zuckerman, Noam Stern-Ginossar, Tomer Israely, Avi Gluck
Publikováno v:
Nature
The coronavirus SARS-CoV-2 is the cause of the ongoing pandemic of COVID-191. Coronaviruses have developed a variety of mechanisms to repress host mRNA translation to allow the translation of viral mRNA, and concomitantly block the cellular innate im
Autor:
Aliki Kapazoglou, Eirini Sarrou, Sophia Letsiou, Ioannis Ganopoulos, Aggeliki Karamaouna, Georgia Tanou, Athanasios Molassiotis, Aliki Xanthopoulou
Publikováno v:
Molecular Biology Reports. 48:4441-4448
There is a persistent interest in innovative and multifunctional ingredients in biology research. With regards to this, natural sources have an important role due to their multiple benefits. Thus, this study aims to present the pleiotropic activity o
Autor:
David M. Gilbert, Shin-ichiro Hiraga, Toyoaki Natsume, Danny Leung, Ipek Tasan, Xuemeng Zhou, Anne D. Donaldson, Meng Zhang, Daniel A. Bartlett, Xiaowen Lyu, Takayo Sasaki, Timour Baslan, Amar M. Singh, Victor G. Corces, Masato T. Kanemaki, Lotte P. Watts, Kyle N. Klein, Stephen Dalton, Huimin Zhao, Peiyao A. Zhao
Publikováno v:
Science
Replication timing organizes epigenome The temporal order of DNA replication is conserved from yeast to humans, but its biological significance remains unclear. Klein et al. eliminated the protein RIF1, a master regulator of replication timing, in se
Autor:
Jian Wu, Pengfei Li, Huaijin Guan, Yu Cao, Xiaojuan Chen, Guowei Zhang, Lihua Kang, Yong Wang, Ying Wang, Tianqiu Zhou
Publikováno v:
Current Eye Research. 46:1353-1362
Purpose DNA damage contributes to the pathogenesis of age-related cataract (ARC) and is repaired through the nucleotide excision repair (NER) pathway, which includes ERCC6. Evidence has demonstrated that defective autophagy leads to lens organelle de