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Publikováno v:
Seminars in Cancer Biology. 85:123-154
The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway involved in cell proliferation and survival. The three-layered MAPK signaling cascade is initiated upon RTK and RAS activation. Three RAF isoforms ARAF, BRAF and CRAF, and their d
Autor:
Pier Paolo Pandolfi, Min Sup Song
Publikováno v:
Seminars in Cancer Biology. 85:43-51
Members of the HECT family of E3 ubiquitin ligases have emerged as prominent regulators of PTEN function, subcellular localization and levels. In turn this unfolding regulatory network is allowing for the identification of genes directly involved in
Publikováno v:
Seminars in Cancer Biology. 85:219-233
Mounting evidence has demonstrated that a myriad of developmental signaling pathways, such as the Wnt, Notch, Hedgehog and Hippo, are frequently deregulated and play a critical role in regulating cancer stem cell (CSC) activity in human cancers, incl
Autor:
Jin Jiang
Publikováno v:
Semin Cancer Biol
Cell-cell communication through evolutionarily conserved signaling pathways governs embryonic development and adult tissue homeostasis. Deregulation of these signaling pathways has been implicated in a wide range of human diseases including cancer. O
Autor:
Salundi Basappa, Gautam Sethi, Chakrabhavi Dhananjaya Mohan, Vijai Kumar Gupta, Habbanakuppe D. Preetham, Shobith Rangappa, S. Chandra Nayaka, Kanchugarakoppal S. Rangappa
Publikováno v:
Seminars in Cancer Biology. 80:157-182
Signal transducer and activator of transcription (STAT) proteins are latent transcription factors that reside in the cytoplasm of several types of cells. In canonical signaling, upon stimulation by cytokines and growth factors, STATs get activated an
Autor:
Ajay Goel, Wenhao Weng
Publikováno v:
Semin Cancer Biol
Colorectal cancer (CRC) is one of most common malignancies worldwide and its incidence is still growing. In spite of recent advances in targeted therapies, their clinical efficacy has been limited, non-curative and unaffordable. A growing body of lit
Publikováno v:
Seminars in Cancer Biology. 80:145-156
Mushrooms, both edible and medicinal have received considerable attention against cancer due to their polysaccharides, polysaccharides-protein complexes and low molecular weight secondary metabolites content. Every year, millions of people die becaus
Autor:
Cornelia Braicu, Ioana Berindan-Neagoe, Alina-Andreea Zimta, Oana Zanoaga, Anupam Bishayee, Kaitlyn L. Kilpatrick, Adrian Bogdan Tigu, Seyed Mohammad Nabavi
Publikováno v:
Seminars in Cancer Biology. 80:218-236
Due to the high number of annual cancer-related deaths, and the economic burden that this malignancy affects today's society, the study of compounds isolated from natural sources should be encouraged. Most cancers are the result of a combined effect
Autor:
Soumya Ranjan Mishra, Chandra Sekhar Bhol, Sujit K. Bhutia, Samir Kumar Patra, Bishnu Prasad Behera, Srimanta Patra, Gautam Sethi, Prakash Priyadarshi Praharaj, Debasna P. Panigrahi, Kewal Kumar Mahapatra
Publikováno v:
Seminars in Cancer Biology. 80:205-217
Autophagy is an intracellular catabolic self-cannibalism that eliminates dysfunctional cytoplasmic cargos by the fusion of cargo-containing autophagosomes with lysosomes to maintain cyto-homeostasis. Autophagy sustains a dynamic interlink between cyt
Publikováno v:
Seminars in Cancer Biology. 80:276-305
Several signaling pathways and basic metabolites are responsible for the control of metabolism in both normal and cancer cells. As emerging hallmarks of cancer metabolism, the abnormal activities of these pathways are of the most noticeable events in