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Autor:
Guo-Bin Huang, Xinhai Zhu, Xiao-Hong Ma, Huan Ma, Qian Bi, Hong-Mei Jiang, Xihui Gan, Si-Yu Chen, Yong-Cong Shao, Silin Li, Hui-Ying Yang, Jinhu Guo, Ye-Bing Yang
Publikováno v:
Biochemical and Biophysical Research Communications. 567:9-16
The circadian clock plays a critical role in synchronizing the inner molecular, metabolic and physiological processes to environmental cues that cycle with a period of 24 h. Non-24 h and shift schedules are commonly used in maritime operations, and b
Severe steatosis and mild colitis are important for the early occurrence of hepatocellular carcinoma
Autor:
Masaru Kumagai, Shunsuke Nojiri, Atsunori Tsuchiya, Shuji Terai, Satoko Motegi, Takeki Sato, Suguru Takeuchi, Takashi Owaki, Yusuke Watanabe, Takahiro Iwasawa, Masahiro Ogawa, Yuzo Kawata, Hiroteru Kamimura
Publikováno v:
Biochemical and Biophysical Research Communications. 566:36-44
The number of patients with non-alcoholic steatohepatitis (NASH) and inflammatory bowel disease (IBD) is increasing. This study elucidates the effect of both NASH and IBD on hepatocellular carcinoma (HCC) using a mouse model combining NASH and IBD. T
Autor:
Wang Duan, Ting Guo, Qinxue Shen, Xiaoli Ouyang, Wei Guo, Qianhui Zhou, Hong Peng, Man Luo, Yaomei Long
Publikováno v:
Biochemical and Biophysical Research Communications. 565:43-49
Fibrocytes originate from the bone marrow monocyte lineage and participate in the pathogenesis of pulmonary fibrosis. Research providing a comprehensive picture of fibrocytes is still limited. Cofilin-1 (CFL-1) is an important protein that regulates
Autor:
Arisa Ochi, Yasumasa Ikeda, Naoki Kashihara, Kojiro Nagai, Kensei Taguchi, Masanori Tamaki, Ken-ichi Aihara, Hideharu Abe, Masashi Miyoshi, Craig R. Brooks, Hiroyuki Kadoya, Kenji Nishimura, Seiji Kishi
Publikováno v:
Biochemical and Biophysical Research Communications. 556:142-148
The relationship between cellular senescence and fibrosis in the kidney is being elucidated and we have identified it as therapeutic target in recent studies. Chronic kidney disease has also become a lifestyle disease, often developing on the backgro
Publikováno v:
Biochemical and Biophysical Research Communications. 555:54-60
Non-alcoholic fatty liver disease (NAFLD) is the pathological manifestation of metabolic syndrome in liver. Its pathological changes may evolve from the initial simple steatosis to non-alcoholic steatohepatitis, liver fibrosis and even liver cancer.
Publikováno v:
Biochemical and Biophysical Research Communications. 553:1-8
Background and aims Hypercholesterolemia is characterized by the elevation of plasma total cholesterol level, especially low-density lipoprotein (LDL) cholesterol. This disease is usually caused by a mutation in genes such as LDL receptor, apolipopro
Autor:
Zhizhuo Huang, Yujun Hao, Jie Yang, Baoyu He, Shishun Huang, Hongli Pan, Delan Luo, Wei Chao, Jianchao Zeng
Publikováno v:
Biochemical and Biophysical Research Communications. 551:100-106
Colorectal cancer (CRC) is prevalent worldwide and novel diagnostic and prognostic biomarkers are needed to improve precision medicine. Circular RNAs (circRNAs) are currently being considered as emerging tumor biomarkers. Herein, we aimed to explore
Publikováno v:
Biochemical and Biophysical Research Communications. 545:1-7
Mammary epithelial cells synthesize and secrete norepinephrine (NE) into breast milk to regulate β-casein expression through the adrenergic β2 receptor. We investigated the expression, localization, and roles of NE transporter (NET) in the mammary
Autor:
Rena Senda, Keigo Katayama, Akihito Morita, Yuki Shimba, Shinji Miura, Yasutomi Kamei, Masahiko Ikeda
Publikováno v:
Biochemical and Biophysical Research Communications. 540:61-66
Calorie restriction (CR) reportedly prevents atherosclerotic diseases. Furthermore, CR induces forkhead box protein-O1 (FOXO-1) expression in the skeletal muscle, altering the character of the skeletal muscle. We previously reported that the change i
Autor:
Angela Song En Huang, Hao Yuan Cheng
Publikováno v:
Biochemical and Biophysical Research Communications
Coronavirus disease 2019 (COVID-19) has become the greatest threat to human society in a century. To better devise control strategies, policymakers should adjust policies based on scientific evidence in hand. Several countries have limited the epidem