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Autor:
Xiao Qian Chen, Shang Bin Yu, Song Lin Yin, Guo Qiang Liu, Feng Hu, Feng Liu, Chun Yang Li, Xiao Hong Xu, Ting Ting Zhang
Publikováno v:
Biochemical and Biophysical Research Communications. 569:1-9
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor without curable therapy. Surgical resection remains the first choice of patients with GBM but tumors relapse rapidly even combined with conventional chemoradiotherapy. The
Publikováno v:
Biochemical and Biophysical Research Communications. 568:30-36
Autophagy, the process of lysosomal degradation of biological materials within cells, is often halted abnormally in proteopathies, such as tauopathy and amyloidopathy. Thus, autophagy regulators that rescue dysregulated autophagy have great potential
Publikováno v:
Biochemical and Biophysical Research Communications. 567:131-137
Our previous research suggested the presence of a novel SETDB1-mediated FosB pathway that could be responsible for the regulation of cell proliferation and invasiveness during anticancer treatments. In this study, we prepared FosB knock-out (FosB-KO)
Publikováno v:
Biochemical and Biophysical Research Communications. 567:92-98
Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that plays an integral role in eliminating abnormal mRNA and corresponding proteins. It is unclear whether the NMD pathway is involved in regulating ferroptosis, which is a type of iro
Autor:
Anjie Xia, Jinliang Yang, Yuxi Wang, Minhao Huang, Lun Tan, Wenting Li, Yuyan Li, Zhixiong Zhang
Publikováno v:
Biochemical and Biophysical Research Communications. 566:197-203
Maytansinoids, the chemical derivatives of Maytansine, are commonly used as potent cytotoxic payloads in antibody-drug conjugates (ADC). Structure-activity-relationship studies had identified the C3 ester side chain as a critical element for antitumo
Publikováno v:
Biochemical and Biophysical Research Communications. 567:118-124
Osteosarcoma is the most common primary orthopedic malignant bone tumor in adolescents. However, the traditional neoadjuvant chemotherapy regimen has reached the bottleneck. TPZ is a hypoxic prodrug that has a powerful anti-tumor effect in the hypoxi
Publikováno v:
Biochem Biophys Res Commun
The emergence of multidrug resistant (MDR) HIV strains severely reduces the effectiveness of antiretroviral therapy. Clinical inhibitor darunavir (1) has picomolar binding affinity for HIV-1 protease (PR), however, drug resistant variants like PR(S17
Publikováno v:
Biochemical and Biophysical Research Communications. 567:183-189
Colon cancer is a common human cancer worldwide. The survival rate of late staged or metastatic colon cancer patients remains low even though the effectiveness of treatment in colon cancer has greatly improved. Research on tumorigenesis mechanisms an
Publikováno v:
Biochemical and Biophysical Research Communications. 565:64-71
Neutrophil extracellular traps (NETs) are extracellular webs of DNA, histones and granular contents that are released by neutrophils to control infections. However, NETs that is not properly regulated can propagate inflammation and thrombosis. It was
Publikováno v:
Biochemical and Biophysical Research Communications. 567:125-130
Differentiated mammary epithelial cells are responsible for milk synthesis during lactation, supporting early postnatal life in mammals. These cells are found in the terminal alveoli of a secretory epithelium, which is surrounded by myoepithelial cel