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Autor:
Maud Magdeleine, Nicolas Fuggetta, Nicolas-Frédéric Lipp, Vanessa Delfosse, William Bourguet, Guillaume Drin, Souade Ikhlef
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-24 (2021)
BMC Biology
BMC Biology, BioMed Central, 2021, 19 (1), pp.248. ⟨10.1186/s12915-021-01183-1⟩
BMC Biology, 2021, 19 (1), pp.248. ⟨10.1186/s12915-021-01183-1⟩
BMC Biology
BMC Biology, BioMed Central, 2021, 19 (1), pp.248. ⟨10.1186/s12915-021-01183-1⟩
BMC Biology, 2021, 19 (1), pp.248. ⟨10.1186/s12915-021-01183-1⟩
Background Lipid species are accurately distributed in the eukaryotic cell so that organelle and plasma membranes have an adequate lipid composition to support numerous cellular functions. In the plasma membrane, a precise regulation of the level of
Autor:
Cleophas Cheruiyot, Antje D. Ebert, Jonathan Bodenschatz, Ruheen Wali, Michael Habeck, Andreas Janshoff, Hang Xu, Gerd Hasenfuss
Publikováno v:
FEBS Letters. 595:2544-2557
We developed an integrated platform for analysis of parameterized data from human disease models. We report a non-negative blind deconvolution (NNBD) approach to quantify calcium (Ca2+ ) handling, beating force and contractility in human-induced plur
Autor:
Ya-Yu Zhao, Chen-Chun Wang, Jia-Lu Ying, Xue Chen, Hong-Bo Jin, Cheng-Cheng Yang, Xin-Yao Yin, Yi-Chi Lu, Pan Du
Publikováno v:
Biochemical and Biophysical Research Communications. 568:103-109
At present, stem cell transplantation has a significant therapeutic effect on spinal cord injury (SCI), however, it is still challenging for the seed cells selection. In this study, in order to explore cells with wide neural repair potentials, we sel
Publikováno v:
Biochemical and Biophysical Research Communications. 568:76-82
Medulloblastoma, the most common malignant brain tumor in children, consists of four molecular subgroups WNT, SHH, Group 3, and Group 4. Group 3 has the worst survival rate among the four subgroups and is characterized by the expression of retina-spe
Autor:
Xiao Qian Chen, Shang Bin Yu, Song Lin Yin, Guo Qiang Liu, Feng Hu, Feng Liu, Chun Yang Li, Xiao Hong Xu, Ting Ting Zhang
Publikováno v:
Biochemical and Biophysical Research Communications. 569:1-9
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor without curable therapy. Surgical resection remains the first choice of patients with GBM but tumors relapse rapidly even combined with conventional chemoradiotherapy. The
Publikováno v:
Biochemical and Biophysical Research Communications. 568:89-94
Manganese (Mn), even though an essential trace element, causes neurotoxicity in excess. In adults, over-exposure to Mn causes clinical manifestations, including dystonia, progressive bradykinesia, disturbance of gait, slurring, and stuttering of spee
Publikováno v:
Biochemical and Biophysical Research Communications. 568:30-36
Autophagy, the process of lysosomal degradation of biological materials within cells, is often halted abnormally in proteopathies, such as tauopathy and amyloidopathy. Thus, autophagy regulators that rescue dysregulated autophagy have great potential
Publikováno v:
Biochemical and Biophysical Research Communications. 567:131-137
Our previous research suggested the presence of a novel SETDB1-mediated FosB pathway that could be responsible for the regulation of cell proliferation and invasiveness during anticancer treatments. In this study, we prepared FosB knock-out (FosB-KO)
Publikováno v:
Biochemical and Biophysical Research Communications. 567:92-98
Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that plays an integral role in eliminating abnormal mRNA and corresponding proteins. It is unclear whether the NMD pathway is involved in regulating ferroptosis, which is a type of iro
Autor:
Anjie Xia, Jinliang Yang, Yuxi Wang, Minhao Huang, Lun Tan, Wenting Li, Yuyan Li, Zhixiong Zhang
Publikováno v:
Biochemical and Biophysical Research Communications. 566:197-203
Maytansinoids, the chemical derivatives of Maytansine, are commonly used as potent cytotoxic payloads in antibody-drug conjugates (ADC). Structure-activity-relationship studies had identified the C3 ester side chain as a critical element for antitumo