Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Crystal L Mackall"'
Publikováno v:
Annual review of cancer biology
Immune-based therapies have now been credentialed for pediatric cancers with the robust efficacy of chimeric antigen receptor (CAR) T cells for pediatric B cell acute lymphocytic leukemia (ALL), offering a chance of a cure for children with previousl
Autor:
Steven A. Feldman, Kara L. Davis, John H. Baird, Robert Lowsky, Rachel C. Lynn, Magali Bazzano, Judith A. Shizuru, Matthew J. Frank, Surbhi Sidana, Maria Caterina Rotiroti, Maria Iglesias, Sean Mackay, Sally Arai, Bita Sahaf, Shabnum Patel, Nirali N. Shah, Laura Johnston, Jay Y. Spiegel, Jing Zhou, Juliana Craig, Robert S. Negrin, Robbie G. Majzner, Andrew R. Rezvani, Zach Ehlinger, Ilan R. Kirsch, Parveen Shiraz, Chelsea D. Mullins, Michael G. Ozawa, Nikolaos Gkitsas, Crystal L. Mackall, Terry J. Fry, Warren D. Reynolds, Yasodha Natkunam, Sneha Ramakrishna, Scott J. Bornheimer, Allison P. Jacob, Lori Muffly, Jean Oak, Haiying Qin, Katherine A. Kong, Wen-Kai Weng, Everett Meyer, Nasheed Hossain, John S. Tamaresis, Sheren F. Younes, David B. Miklos, Liora M. Schultz, Eric J Yang, Harshini Chinnasamy
Publikováno v:
Nature Medicine
Despite impressive progress, more than 50% of patients treated with CD19-targeting chimeric antigen receptor T cells (CAR19) experience progressive disease. Ten of 16 patients with large B cell lymphoma (LBCL) with progressive disease after CAR19 tre
Autor:
Aidan Tousley, Sabine Heitzeneder, Johanna Theruvath, Robbie G. Majzner, Skyler P. Rietberg, Elena Sotillo, Volker Wiebking, Ronald D. Vale, Rui Dong, Rebecca Richards, Peng Xu, Evan W. Weber, Alexander R. Dunn, Rachel C. Lynn, Louai Labanieh, Vipul T. Vachharajani, Sang M. Nguyen, Meena Kadapakkam, Crystal L. Mackall, June Helen Myklebust
Publikováno v:
Cancer Discov
Cancer discovery, vol 10, iss 5
Cancer discovery, vol 10, iss 5
Insufficient reactivity against cells with low antigen density has emerged as an important cause of chimeric antigen receptor (CAR) T-cell resistance. Little is known about factors that modulate the threshold for antigen recognition. We demonstrate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37be618bc24a6cfd2084ac1ba61efbba
https://europepmc.org/articles/PMC7939454/
https://europepmc.org/articles/PMC7939454/
Autor:
D. Williams Parsons, Paul S. Meltzer, Sharon E. Plon, Douglas S. Hawkins, Crystal L. Mackall, Steven G. DuBois, Lisa Mirabello, R. Lor Randall, Katherine A. Janeway, Poul H. Sorensen, Ching C. Lau, Rajen Mody, Malcolm A. Smith, Carol J. Bult, Pooja Hingorani, Sharon A. Savage, Javed Khan, Richard Gorlick, Stephen X. Skapek, Cigall Kadoch, Damon R. Reed, Peter C. Adamson, Philip J. Lupo, Marc Ladanyi, Jack F. Shern, Brian D. Crompton, Stephen L. Lessnick, Joshua D. Schiffman, Chand Khanna
Publikováno v:
Cancer genetics, vol 209, iss 5
Sarcomas are a rare subgroup of pediatric cancers comprised of a variety of bone and soft-tissue tumors. While significant advances have been made in improving outcomes of patients with localized pediatric sarcomas since the addition of systemic chem
Autor:
Sang M. Nguyen, Michael C. Jensen, Haiying Qin, Jack F. Shern, Daniel W. Lee, Haiyan Lei, Javed Khan, Kathryn M. Welp, Thomas J. Fountaine, Rebecca Gardner, Elad Jacoby, Berkley E. Gryder, Yinmeng Yang, Young K. Song, Terry J. Fry, Christopher D. Chien, Crystal L. Mackall, Alix E. Seif
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Adoptive immunotherapy using chimeric antigen receptor (CAR) expressing T cells targeting the CD19 B lineage receptor has demonstrated marked success in relapsed pre-B-cell acute lymphoblastic leukaemia (ALL). Persisting CAR-T cells generate sustaine
Autor:
Jiaqiang Ren, Hanh Khuu, Minh Tran, Crystal L. Mackall, Sue Ellen Frodigh, Melinda S. Merchant, David F. Stroncek, Daniel W. Lee, Marianna Sabatino
Background aims Autologous chimeric antigen receptor (CAR) T-cell therapies have shown promising clinical outcomes, but T-cell yields have been variable. CD19- and GD2-CAR T-cell manufacturing records were reviewed to identify sources of variability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c13f850306b0fc264f7e656225e291c
https://europepmc.org/articles/PMC4898642/
https://europepmc.org/articles/PMC4898642/