Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kevin J Harrington"'
Autor:
Burak Gumuscu, Kevin J. Harrington, Hoi-Shen Radcliffe, Lillian L. Siu, Wendy Snyder, Danny Rischin, Beatriz Castelo Fernandez, Ezra E.W. Cohen, Jason Chesney, Anthony Kong, Jonathan D. Cheng, Nicolas Mach
Publikováno v:
Clinical Cancer Research, Vol. 26, No 19 (2020) pp. 5153-5161
Purpose: The prognosis for patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) is poor, and only a minority of patients benefit from checkpoint immunotherapy. Talimogene laherparepvec (T-VEC), an oncolytic immunoth
Autor:
Jeffery S. Russell, Shanmugasundaram Ramkumar, Everett E. Vokes, Robert L. Ferris, Makoto Tahara, Maura L. Gillison, Lisa Licitra, Mark Lynch, Robert I. Haddad, Joël Guigay, Caroline Even, Nabil F. Saba, Kevin J. Harrington, Fernando Concha-Benavente, Jérôme Fayette, Li Li, Peter Brossart, George R. Blumenschein, A. Dimitrios Colevas
Publikováno v:
Clin Cancer Res
Purpose: Cetuximab, which modulates immune responses, may affect the efficacy of subsequent immunotherapy. Here, we assessed outcomes with nivolumab, by prior cetuximab exposure, in patients with recurrent or metastatic (R/M) squamous cell carcinoma
Autor:
Kate Newbold, Shreerang Bhide, Alan Melcher, Amy Trinh, KH Wong, Pablo Nenclares, Lucinda Gunn, Heba Soliman, Mateo Bover, Kevin J. Harrington, Christopher M. Nutting, Isla Leslie, Derfel Ap Dafydd
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
BackgroundPrevious studies have suggested that inflammatory markers (neutrophil-to-lymphocyte ratio (NLR), lactate dehydrogenase (LDH) and fibrinogen) are prognostic biomarkers in patients with a variety of solid cancers, including those treated with
Autor:
Mansour T. A. Sharabiani, Paul Carter, S.A. Bhide, Kevin J. Harrington, R. Shaikh, Isaac Garcia-Murillas, D.M. Allin, Katie L. Newbold, Khin Thway, D. Kim, D. Gonzales-de-Castro, Ben O'Leary, Mike Hubank
Publikováno v:
European Journal of Cancer. 103:165-175
Background Conventional biomarkers in thyroid cancer are not disease specific and fluctuate in advanced disease, making interpretation difficult. Circulating tumour DNA (ctDNA) has been shown to be a useful biomarker in other solid tumours. This is a
Autor:
Jonathan D. Cheng, Barbara Burtness, José Dinis, Misoo C. Ellison, Nicolas Mach, Christophe Le Tourneau, Diana Chirovsky, Ainara Soria, Ramona F. Swaby, Lisa Licitra, Kevin J. Harrington, Denis Soulières, Myung-Ju Ahn, Ranee Mehra, Ezra E.W. Cohen, Jean-Pascal Machiels
Publikováno v:
Journal of the National Cancer Institute, Vol. 113, no.2, p. 171-181 (2021)
J Natl Cancer Inst
Journal of the National Cancer Institute, vol 113, iss 2
Journal of the National Cancer Institute, Vol. 113, No 2 (2021) pp. 171-181
J Natl Cancer Inst
Journal of the National Cancer Institute, vol 113, iss 2
Journal of the National Cancer Institute, Vol. 113, No 2 (2021) pp. 171-181
Background Head and neck squamous cell carcinoma (HNSCC) affects health-related quality of life (HRQoL); few treatments have demonstrated clinically meaningful HRQoL benefit. KEYNOTE-040 evaluated pembrolizumab vs standard of care (SOC) in patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c605279800d9cce11c0a442019697bb
https://hdl.handle.net/2078.1/245855
https://hdl.handle.net/2078.1/245855
Autor:
Sara Reis, Intan Hamid, Sophie McGrath, Susannah Stanway, Alicia Okines, Jaishree Bhosle, Vasileios Angelis, Marco Gerlinger, Heba Soliman, Zayd Tippu, Firza Gronthoud, Robin L. Jones, Emma Cottier, Charlotte Fribbens, Jillian Noble, David Watkins, Spyridon Gennatas, Kroopa Joshi, Pablo Nenclares, Kevin J. Harrington
Publikováno v:
European Journal of Cancer
Background In light of the coronavirus disease 2019 (COVID-19) pandemic, cancer centres in the United Kingdom and Europe re-organised their services at an unprecedented pace, and many patients with cancer have had their treatments severely disrupted.
Autor:
Brian Ng-Cheng-Hin, D. McQuaid, Kate Newbold, Shreerang Bhide, Alex Dunlop, Kee Howe Wong, Christopher M. Nutting, Kevin J. Harrington
Publikováno v:
The British Journal of Radiology
Objective: This study investigates the impact of a restricted craniocaudal (CC) field length of Methods: 110 HNC patients who underwent radical primary or adjuvant radiotherapy were retrospectively analysed. We assessed the proportion of treatment fi
Autor:
Kevin J. Harrington, Pablo Nenclares, Sheerang A. Bhide, Alan Melcher, Kate Newbold, Christopher M. Nutting, Pierre Pialat, Helena Sandoval-Insausti, Lucinda Gunn
Publikováno v:
European journal of cancer (Oxford, England : 1990). 131
Background Pre-clinical evidence suggests reduced efficacy of anticancer treatment in patients exposed to broad-spectrum antibiotics. It is hypothesised that this phenomenon may be explained by the effects of antibiotics on the composition of the mic
Autor:
Shreerang Bhide, Aisha Miah, Sarah L. Gulliford, James P Morden, Kevin J. Harrington, Shane Zaidi, Katie L. Newbold, Emma Hall, Christopher M. Nutting
Publikováno v:
Clinical Oncology (Royal College of Radiologists (Great Britain)
Aims To establish whether there is a difference in recovery of salivary function with bilateral superficial lobe parotid-sparing intensity-modulated radiotherapy (BSLPS-IMRT) versus contralateral parotid-sparing IMRT (CLPS-IMRT) in patients with loca
Autor:
Éva Remenár, Martin Forster, Judit Kocsis, Magnus T. Dillon, Jonathan Greenberg, Frederic Rolland, Gábor Pajkos, Kevin J. Harrington
Publikováno v:
European journal of cancer (Oxford, England : 1990). 123
Background The fully human monoclonal antibody patritumab blocks HER3 activation, a resistance mechanism to cetuximab, induced by heregulin (HRG). A phase Ib study in recurrent and/or metastatic (R/M) squamous cell carcinoma of the head and neck (SCC