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Publikováno v:
Seminars in Cancer Biology. 86:1207-1217
The development of microbial products for cancer treatment has been in the spotlight in recent years. In order to accelerate the lengthy and expensive drug development process, in silico screening tools are systematically employed, especially during
Autor:
Elizabeth Bancroft, Chee Goh, Elizabeth Page, Zsofia Kote-Jarai, Elena Castro, Christos Mikropoulos, Edward J. Saunders, Nandita M. deSouza, David E. Neal, Stephen Hazell, Antonis C. Antoniou, Natalie Taylor, Pardeep Kumar, Nigel Borley, Rosalind A. Eeles, Freddie C. Hamdy, Sibel Saya, Naomi Livni, Diana Keating, Tokhir Dadaev
Publikováno v:
The Oncologist
A better assessment of prostate cancer (PrCa) risk is needed to improve screening. The PROFILE pilot study explored the feasibility of single nucleotide polymorphism profiling in men with a family history (FH) of PrCa to investigate the probability o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530db08f3b0071b7ef326b41d3c41f1a
https://ora.ox.ac.uk/objects/uuid:5985ee3f-ba82-44cd-9894-a0e866e55da9
https://ora.ox.ac.uk/objects/uuid:5985ee3f-ba82-44cd-9894-a0e866e55da9
Autor:
Christer S. Ejsing, Sandra F Gallego, Anthony H. Futerman, Richard R. Sprenger, Ole N. Jensen, Nanna Albæk, Steffen Schmidt, Marie W. Lindholm, Charlotte Øverup, Yael Pewzner-Jung, Sergey Kovalchuk, Iris D. Zelnik
Publikováno v:
Mol Ther
Schmidt, S, Gallego, S F, Zelnik, I D, Kovalchuk, S, Albæk, N, Sprenger, R R, Øverup, C, Pewzner-Jung, Y, Futerman, A H, Lindholm, M W, Jensen, O N & Ejsing, C S 2022, ' Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death ', Molecular Therapy, vol. 30, no. 4, pp. 1661-1674 . https://doi.org/10.1016/j.ymthe.2021.08.021
Schmidt, S, Gallego, S F, Zelnik, I D, Kovalchuk, S, Albæk, N, Sprenger, R R, Øverup, C, Pewzner-Jung, Y, Futerman, A H, Lindholm, M W, Jensen, O N & Ejsing, C S 2022, ' Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death ', Molecular Therapy, vol. 30, no. 4, pp. 1661-1674 . https://doi.org/10.1016/j.ymthe.2021.08.021
Emerging clinical data show that three ceramide molecules, Cer d18:1/16:0, Cer d18:1/24:1, and Cer d18:1/24:0, are biomarkers of a fatal outcome in patients with cardiovascular disease. This finding raises basic questions about their metabolic origin
Autor:
Tuan Zea Tan, Alexander Dobrovic, Erik W. Thompson, Marcin Szaumkessel, Anh Viet-Phuong Le, Jean Paul Thiery
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 9, p 2553 (2018)
International Journal of Molecular Sciences
Volume 19
Issue 9
International Journal of Molecular Sciences
Volume 19
Issue 9
(1) Background: Epithelial&ndash
mesenchymal plasticity (EMP) is a dynamic process whereby epithelial carcinoma cells reversibly acquire morphological and invasive characteristics typical of mesenchymal cells. Identifying the methylation differe
mesenchymal plasticity (EMP) is a dynamic process whereby epithelial carcinoma cells reversibly acquire morphological and invasive characteristics typical of mesenchymal cells. Identifying the methylation differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1084d785e8aca35cc7375771ee934927
Autor:
Andrew J. Lucke, Robert Reid, Soo-Hyun Kim, Lap Hing Chi, Robin L. Anderson, Delphine Denoyer, Ana Carolina Baptista Moreno Martin, David P. Fairlie, Xiawei Ling, Normand Pouliot, Richard P. Redvers
Publikováno v:
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 11, Iss 7 (2018)
Disease Models & Mechanisms, Vol 11, Iss 7 (2018)
Breast cancer brain metastases remain largely incurable. Although several mouse models have been developed to investigate the genes and mechanisms regulating breast cancer brain metastasis, these models often lack clinical relevance since they requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad56f1b36d405e67a45166beae88dcbe
Autor:
John M. Mariadason, Paul C. Boutros, Gavin M. Wright, Mun Sem Liew, Thomas John, Aparna Jayachandran, Anderly C. Chueh, Maud H.W. Starmans, Stephen Barnett, Prudence A. Russell, Marzena Walkiewicz
Publikováno v:
Oncotarget
Oncotarget, vol 8, iss 43
Oncotarget, vol 8, iss 43
Cancer-Testis antigens (CTA) are immunogenic molecules with normal tissue expression restricted to testes but with aberrant expression in up to 30% of non-small cell lung cancers (NSCLCs). Regulation of CTA expression is mediated in part through prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3c9cbe6ee2025e8af7e3a77b76257a
Autor:
Luděk Záveský, Veronika Hanzíková, Eva Jandáková, Ondřej Slanař, Milada Kohoutová, Vít Weinberger
Publikováno v:
Cancer Biomarkers. 33:1-16
Ovarian cancer comprises the most lethal gynecologic malignancy and is accompanied by the high potential for the incidence of metastasis, recurrence and chemotherapy resistance, often associated with a formation of ascitic fluid. The differentially e
Publikováno v:
Trends Cancer
Trends in cancer, vol 8, iss 2
Trends in Cancer
Trends in Cancer, Cell Press, 2021, ⟨10.1016/j.trecan.2021.10.008⟩
Trends in Cancer, 2022, 8 (2), pp.87-97. ⟨10.1016/j.trecan.2021.10.008⟩
Trends in cancer, vol 8, iss 2
Trends in Cancer
Trends in Cancer, Cell Press, 2021, ⟨10.1016/j.trecan.2021.10.008⟩
Trends in Cancer, 2022, 8 (2), pp.87-97. ⟨10.1016/j.trecan.2021.10.008⟩
International audience; The unexpected roles of the microbiota in cancer challenge explanations of carcinogenesis that focus on tumor-intrinsic properties. Most tumors contain bacteria and viruses, and the host’s proximal and distal microbiota infl
Autor:
Ming Li, Quan Li, Ni Liu, Frances A. Shepherd, Teklab Gebregiworgis, Ming-Sound Tsao, Nadeem Moghal, Nhu-An Pham, Mitsuhiko Ikura, Ningdi Feng Liu, Zhenhao Fang, Hirotsugu Notsuda, Ku-Geng Huo, Christopher B. Marshall
Publikováno v:
Journal of Thoracic Oncology. 17:277-288
Introduction Mutations in BRAF occur in 2-4% of lung adenocarcinoma (LUAD) patients. Combination dabrafenib/trametinib or single-agent vemurafenib is approved only for patients with cancers driven by the V600E BRAF mutation. Targeted therapy is not c
Autor:
Jean-Philippe Hugnot, Liang Yi, Tian-qing Chen, Ji Zhou, Qing-mei Kang, Jun Wang, Shi-cang Yu
Publikováno v:
Cancer Letters
Cancer Letters, Elsevier, 2021, pp.S0304-3835(21)00587-5. ⟨10.1016/j.canlet.2021.11.020⟩
Cancer Letters, Elsevier, 2022, 526, pp.103-111. ⟨10.1016/j.canlet.2021.11.020⟩
Cancer Letters, Elsevier, 2021, pp.S0304-3835(21)00587-5. ⟨10.1016/j.canlet.2021.11.020⟩
Cancer Letters, Elsevier, 2022, 526, pp.103-111. ⟨10.1016/j.canlet.2021.11.020⟩
International audience; Invasive growth along white matter (WM) tracts is one of the most prominent clinicopathological features of glioma and is also an important reason for surgical treatment failure in glioma patients. A full understanding of rele