Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Daniel D. De Carvalho"'
Publikováno v:
Cancer Discovery. 11:2707-2725
Features of the cancer epigenome distinguish cancers from their respective cell of origin and establish therapeutic vulnerabilities that can be exploited through pharmacologic inhibition of DNA- or histone-modifying enzymes. Epigenetic therapies conv
Autor:
Thomas Kislinger, Jeffrey Zuccato, Shahbaz Khan, Yasin Mamatjan, Sébastien Froelich, Gelareh Zadeh, Namita Sinha, Shirin Karimi, Olivia Singh, Jeffrey C Liu, Ankur Chakravarthy, Anne-Laure Bernat, Joao Paulo Almeida, Homa Adle-Biassette, Farshad Nassiri, Sheila Mansouri, Vikas Patil, Kenneth Aldape, Mohammed Hasen, Daniel D. De Carvalho
Publikováno v:
Neuro Oncol
Background Chordomas are rare malignant bone cancers of the skull-base and spine. Patient survival is variable and not reliably predicted using clinical factors or molecular features. This study identifies prognostic epigenetic chordoma subtypes that
Autor:
Helen Loo Yau, Parinaz Mehdipour, Ilias Ettayebi, Charles A. Ishak, Ankur Chakravarthy, Daniel D. De Carvalho, Catherine A. O’Brien, Amir H. Hosseini, Fabíola Attié de Castro, Yadong Wang, Sagi Abelson, Sajid A. Marhon
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Cancer therapies that target epigenetic repressors can mediate their effects by activating retroelements within the human genome. Retroelement transcripts can form double-stranded RNA (dsRNA) that activates the MDA5 pattern recognition receptor1–6.
Autor:
Karan J. Abraham, Miling Wang, Jack Greenblatt, Lauren A. Ostrowski, Aparna Gorthi, Parasvi S. Patel, Daniel D. De Carvalho, Razq Hakem, Michael Ohh, Roxanne Oshidari, Alexander J.R. Bishop, Violena Pietrobon, Anas Samman, Arash Algouneh, Dorothy Yanling Zhao, Stephen Lee, Michael Bokros, Janet N.Y. Chan, V Talya Yerlici, Rajat Singhania, Brendan C. Dickson, Yupeng Liu, Elva Vidya, Negin Khosraviani, Karim Mekhail
Publikováno v:
Nature
Proteins are manufactured by ribosomes—macromolecular complexes of protein and RNA molecules that are assembled within major nuclear compartments called nucleoli1,2. Existing models suggest that RNA polymerases I and III (Pol I and Pol III) are the
Publikováno v:
Nature Protocols. 14:2749-2780
Circulating cell-free DNA (cfDNA) comprises small DNA fragments derived from normal and tumor tissue that are released into the bloodstream. Recently, methylation profiling of cfDNA as a liquid biopsy tool has been gaining prominence due to the prese
Publikováno v:
Trends in Cell Biology. 29:31-43
During cancer initiation and progression, the somatic epigenome is broadly reprogrammed. This reprogramming can be a consequence of several processes, including altered transcriptional profiles and mutations. In addition, immune cells infiltrating th
Autor:
Bo Zhang, Yasheng Zhu, Xiaojie Bian, Mingyao Liu, Daniel D. De Carvalho, Chao Wang, Zhengfang Yi, Yu-Tian Xiao, Song Wu, Housheng Hansen He, Fraser Soares, Paul C. Boutros, Theodorus H. van der Kwast, Zhou Jiang, Ke-Qin Dong, Javier Mariscal, Jianhua Wang, Helen Loo Yau, Alejandro Berlin, Guanghui Zhu, Qinghua Guo, Weidong Chen, Fubo Wang, Shancheng Ren, Yongwei Yu, Yue Yang, Dolores Di Vizio, Na Zhang, Michael Fraser, Fei Liu, Dai Chen, Yin Liu, Sujun Chen
Publikováno v:
Nature cell biology. 23(1)
Prostate cancer shows remarkable clinical heterogeneity, which manifests in spatial and clonal genomic diversity. By contrast, the transcriptomic heterogeneity of prostate tumours is poorly understood. Here we have profiled the transcriptomes of 36,4
Autor:
Giselle M. Boukhaled, David G. Brooks, Felipe Campos de Almeida, David Allard, Sajid A. Marhon, David Roulois, Joaquín Arribas, Ilias Ettayebi, Tiago Medina, Parinaz Mehdipour, Gustavo P. Amarante-Mendes, Sandra Pommey, John Stagg, Daniel D. De Carvalho, Helen Loo Yau, Isabela M. Gonzaga, Shu Yi Shen, Ankur Chakravarthy, Christian Klein, Beatriz Morancho, Raymond Chen, Emma Bell, Charles A. Ishak, Rajat Singhania
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Molecular Cell
Molecular Cell, Elsevier, 2021, 81 (7), pp.1469-1483.e8. ⟨10.1016/j.molcel.2021.01.038⟩
Molecular Cell, 2021, 81 (7), pp.1469-1483.e8. ⟨10.1016/j.molcel.2021.01.038⟩
Universidade de São Paulo (USP)
instacron:USP
Molecular Cell
Molecular Cell, Elsevier, 2021, 81 (7), pp.1469-1483.e8. ⟨10.1016/j.molcel.2021.01.038⟩
Molecular Cell, 2021, 81 (7), pp.1469-1483.e8. ⟨10.1016/j.molcel.2021.01.038⟩
International audience; We demonstrate that DNA hypomethylating agent (HMA) treatment can directly modulate the anti-tumor response and effector function of CD8(+) T cells. In vivo HMA treatment promotes CD8(+) T cell tumor infiltration and suppresse
Autor:
Daniel D. De Carvalho, Helen Loo Yau
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100549-(2021)
STAR Protocols
STAR Protocols
Summary CD8+ T cells are key effector cells in adaptive immune responses against intracellular pathogens and cancer cells. Systemic drug treatments, like chemotherapy, may positively or negatively affect CD8+ T cell function. In this protocol, we des
Autor:
Michelle Chan-Seng-Yue, Stanley Zhou, Kerstin B. Kaufmann, Héléna Boutzen, Ken Kron, John J.Y. Lee, Naoya Takayama, Laura García-Prat, Tiago Medina, Michael D. Taylor, Juan M. Vaquerizas, John E. Dick, Noelia Díaz, Shin-ichiro Takayanagi, Mathieu Lupien, Alex Murison, Aaron Trotman-Grant, Christopher Arlidge, Sasan Zandi, Stephanie Z. Xie, Daniel D. De Carvalho, Olga I. Gan, Erwin M. Schoof
Publikováno v:
Cell Stem Cell. 28:488-501.e10
Lifelong blood production requires long-term hematopoietic stem cells (LT-HSCs), marked by stemness states involving quiescence and self-renewal, to transition into activated short-term HSCs (ST-HSCs) with reduced stemness. As few transcriptional cha