Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ye Chen-Izu"'
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 31
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 31
Significance The heart autoregulates its contractile strength to maintain cardiac output when pumping blood against the mechanical afterload from vascular resistance. Increased afterload in cardiovascular diseases is associated with cardiac arrhythmi
Autor:
Zhong Jian, Leighton T. Izu, Mohammad A. Kazemi-Lari, Bence Hegyi, Rafael Shimkunas, Anthony J. Baker, Tamás Bányász, Ye Chen-Izu, John A. Shaw
Publikováno v:
Life
Life (Basel, Switzerland), vol 11, iss 6
Life, Vol 11, Iss 503, p 503 (2021)
Volume 11
Issue 6
Life (Basel, Switzerland), vol 11, iss 6
Life, Vol 11, Iss 503, p 503 (2021)
Volume 11
Issue 6
The heart has two intrinsic mechanisms to enhance contractile strength that compensate for increased mechanical load to help maintain cardiac output. When vascular resistance increases the ventricular chamber initially expands causing an immediate le
Autor:
G. R. Reddy, Ye Chen-Izu, Toni M. West, Qian Shi, Ying Wang, Yang Kevin Xiang, Zhong Jian, Mark Jaradeh
Publikováno v:
The Journal of General Physiology
FRET-based biosensors are powerful tools to study intracellular signaling that require long culture times for adenoviral infection. Reddy et al. have developed a method for culturing adult mouse cardiomyocytes involving blebbistatin, which preserves
Autor:
Donald M. Bers, Tamás Bányász, Penelope A. Boyden, Leighton T. Izu, Masahito Miura, Peter Kohl, Nipavan Chiamvimonvat, Natalia A. Trayanova, Ye Chen-Izu
Publikováno v:
The Journal of physiology, vol 598, iss 7
J Physiol
J Physiol
Cardiac excitation-contraction (E-C) coupling is influenced by (at least) three dynamic systems that couple and feedback to one another (Abstract Figure). Here we review the mechanical effects on cardiomyocytes that include mechano-electro-transducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f41721d7c30e03e5f20d2de4616d8aa
https://escholarship.org/uc/item/2dj257vh
https://escholarship.org/uc/item/2dj257vh
Autor:
Xiao-Dong Zhang, Hannah A. Ledford, Ingrid Brust-Mascher, Gu Dai, Nipavan Chiamvimonvat, Padmini Sirish, Leighton T. Izu, Ye Chen-Izu, Zhong Jian, Jeong-Han Lee, Wei Chun Chen, Ebenezer N. Yamoah, Zana Coulibaly, Frank Y. S. Chuang
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific reports, vol 8, iss 1
Scientific reports, vol 8, iss 1
Small-conductance Ca2+-activated K+ (SK) channels regulate the excitability of cardiomyocytes by integrating intracellular Ca2+ and membrane potentials on a beat-to-beat basis. The inextricable interplay between activation of SK channels and Ca2+ dyn
Autor:
Leighton T. Izu, Ye Chen-Izu
Publikováno v:
The Journal of Physiology. 595:3949-3958
The heart has the ability to adjust to changing mechanical loads. The Frank-Starling law and the Anrep effect describe exquisite intrinsic mechanisms the heart has for autoregulating the force of contraction to maintain cardiac output under changes o
Autor:
Jeanne M. Nerbonne, Eleonora Grandi, James N. Weiss, Zhilin Qu, Dobromir Dobrev, Michael C. Sanguinetti, Leighton T. Izu, Donald M. Bers, Nipavan Chiamvimonvat, Gideon Koren, Crystal M. Ripplinger, Jordi Heijman, Colleen E. Clancy, Isabelle Deschenes, Jamie I. Vandenberg, Ye Chen-Izu, Tamás Bányász
Publikováno v:
The Journal of Physiology. 595:2229-2252
This is the second of the two White Papers from the fourth UC Davis Cardiovascular Symposium Systems Approach to Understanding Cardiac Excitation-Contraction Coupling and Arrhythmias (3-4 March 2016), a biennial event that brings together leading exp
Autor:
Eleonora Grandi, Catherine Proenza, Jamie I. Vandenberg, Michael C. Sanguinetti, Sergei Y. Noskov, Ye Chen-Izu, Brian P. Delisle, Vladimir Yarov-Yarovoy, Donald M. Bers, Daniel C. Bartos, Jordi Heijman, Henry M. Colecraft, Manuel F. Navedo, Nipavan Chiamvimonvat
Publikováno v:
The Journal of Physiology. 595:2209-2228
This paper is the outcome of the fourth UC Davis Systems Approach to Understanding Cardiac Excitation-Contraction Coupling and Arrhythmias Symposium, a biannual event that aims to bring together leading experts in subfields of cardiovascular biomedic
Publikováno v:
Biophysical Journal. 111:1304-1315
In the heart, Na + is a key modulator of the action potential, Ca 2+ homeostasis, energetics, and contractility. Because Na + currents and cotransport fluxes depend on the Na + concentration in the submembrane region, it is necessary to accurately es
Autor:
Katherina M. Alsina, Na Li, Jose L. Puglisi, Donald M. Bers, Xander H.T. Wehrens, Razvan L. Cornea, Hitoshi Uchinoumi, Tetsuro Oda, Ye Chen-Izu, Yi Yang
Publikováno v:
Uchinoumi, H; Yang, Y; Oda, T; Li, N; Alsina, KM; Puglisi, JL; et al.(2016). CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. Journal of Molecular and Cellular Cardiology, 98, 62-72. doi: 10.1016/j.yjmcc.2016.06.007. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/9vw6k9jp
© 2016 Elsevier Ltd Diastolic calcium (Ca) leak via cardiac ryanodine receptors (RyR2) can cause arrhythmias and heart failure (HF). Ca/calmodulin (CaM)-dependent kinase II (CaMKII) is upregulated and more active in HF, promoting RyR2-mediated Ca le