Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Tim D. Spector"'
Publikováno v:
British Journal of Cancer
The gut microbiome (GM) has been implicated in a vast number of human pathologies and has become a focus of oncology research over the past 5 years. The normal gut microbiota imparts specific function in host nutrient metabolism, xenobiotic and drug
Autor:
Wei Yuan, Pirro G. Hysi, Charles A. Mein, Elaine M. Dennison, Jordana T. Bell, Richard J. Acton, Fei Gao, Karen A. Lillycrop, Jun Wang, Eva Wozniak, Nicholas C Harvey, Yudong Xia, Tim D. Spector, Christopher G. Bell, Emma Bourne, Cyrus Cooper
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Understanding how the epigenome deteriorates with age and subsequently impacts on biological function may bring unique insights to ageing-related disease mechanisms. As a central cellular apparatus, tRNAs are fundamental to the information flow from
Autor:
Jonathan Wolf, Michela Antonelli, Anna May, Christina M Astley, Liane S Canas, Ruth C. E. Bowyer, Marc Modat, Erika Molteni, Thomas Varsavsky, Andrew T. Chan, Sebastien Ourselin, Frances M K Williams, Joan Capdevila Pujol, Long H. Nguyen, Richard Davies, Sajaysurya Ganesh, Kerstin Klaser, Carole H. Sudre, Jordi Merino, Tove Fall, Rose S. Penfold, Neli Tsereteli, Tim D. Spector, Paul W. Franks, Cristina Menni, Maria F. Gomez, M. Jorge Cardoso, Claire J. Steves, David A. Drew, Amit Joshi, Emma L. Duncan, Benjamin J. Murray, Mark S. Graham
Publikováno v:
Nature Medicine
Nature Medicine, Nature Publishing Group, 2021, 27 (4), pp.626-631. ⟨10.1038/s41591-021-01292-y⟩
Nat Med
Nature Medicine, Nature Publishing Group, 2021, 27 (4), pp.626-631. ⟨10.1038/s41591-021-01292-y⟩
Nat Med
Reports of long-lasting coronavirus disease 2019 (COVID-19) symptoms, the so-called ‘long COVID’, are rising but little is known about prevalence, risk factors or whether it is possible to predict a protracted course early in the disease. We anal
Autor:
Gianmarco Piccinno, Chloe Mirzayi, Caroline I. Le Roy, Nicola Segata, Christopher Bonnett, Rachel J. Gibson, Adrian Tett, Francesco Asnicar, Sehyun Oh, Andrew T. Chan, Serge Danzanvilliers, Curtis Huttenhower, Lucy Francis, George Hadjigeorgiou, Francesca Giordano, Mohsen Mazidi, Ana M. Valdes, Joan Capdevila, Jonathan Wolf, Richard Davies, Leonard Dubois, Jose M. Ordovas, Olatz Mompeo, Ludwig Geistlinger, Asya Khleborodova, Christopher D. Gardner, Levi Waldron, Rachel Hine, Sarah Berry, Davide Bazzani, Haya Al Khatib, David A. Drew, Francesco Beghini, Long H. Nguyen, Mireia Valles-Colomer, Andrew Maltez Thomas, Tim D. Spector, Paul W. Franks, Emily R Leeming
Publikováno v:
Nature Medicine
The gut microbiome is shaped by diet and influences host metabolism; however, these links are complex and can be unique to each individual. We performed deep metagenomic sequencing of 1,203 gut microbiomes from 1,098 individuals enrolled in the Perso
Autor:
Nicholas J. Timpson, Jackie F. Price, Henning Tiemeier, Caroline Hayward, Stephan J. L. Bakker, Christian Gieger, Tom Michoel, Catriona L. K. Barnes, Ville Karhunen, Peter K. Joshi, Katyayani Sukhavasi, Anubha Mahajan, Carol A. Wang, Igor Rudan, Maik Pietzner, Andrew P. Morris, Craig E. Pennell, Andrew A Crawford, Marjo-Riitta Järvelin, Henry Völzke, Harry Campbell, Johan L.M. Björkegren, Pim van der Harst, David W. Clark, Massimo Mangino, Claes Ohlsson, Tim D. Spector, Jari Lahti, Elisabeth Altmaier, Johan G. Eriksson, Alexander Neumann, Raili Ermel, Maria Nethander, Arno Ruusalepp, James R M Wilson, George Davey Smith, Nele Friedrich, Sean Bankier, Brian R. Walker, Stela McLachlan
Publikováno v:
Journal of human genetics
Journal of Human Genetics
Crawford, A, Bankier, S, Altmaier, E, Barnes, C L K, Clark, D W, Ermel, R, Friedrich, N, van der Harst, P, Joshi, P K, Karhunen, V, Lahti, J, Mahajan, A, Mangino, M, Nethander, M, Neumann, A, Pietzne, M, Sukhavasi, K, Wang, C A, Bakker, S J L, Björkegren, J L M, Campbell, H, Eriksson, J, Gieger, C, Hayward, C, Jarvelin, M-R, McLachlan, S, Morris, A P, Ohlsson, C, Pennell, C E, Price, J F, Rudan, I, Ruusalepp, A, Spector, T D, Tiemeier, H, Völzke, H, Wilson, J F, Michoel, T, Timpson, N J, Davey Smith, G & Walker, B R 2021, ' Variation in the SERPINA6SERPINA1 locusalters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expressionin peripheral tissues, and risk of cardiovascular disease ', Journal of Human Genetics . https://doi.org/10.1038/s10038-020-00895-6
Journal of human genetics, 66(6), 625-636. Nature Publishing Group
Journal of Human Genetics, 66(6), 625-636. Nature Publishing Group
Crawford, A A, Bankier, S, Altmaier, E, Barnes, C L K, Clark, D W, Ermel, R, Friedrich, N, Van Der Harst, P, Joshi, P K, Karhunen, V, Lahti, J, Mahajan, A, Mangino, M, Nethander, M, Neumann, A, Pietzner, M, Sukhavasi, K, Wang, C A, Bakker, S J L, Bjorkegren, J L M, Campbell, H, Eriksson, J, Gieger, C, Hayward, C, Jarvelin, M, Mclachlan, S, Morris, A P, Ohlsson, C, Pennell, C E, Price, J, Rudan, I, Ruusalepp, A, Spector, T, Tiemeier, H, Völzke, H, Wilson, J F, Michoel, T, Timpson, N J, Smith, G D & Walker, B R 2021, ' Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease ', Journal of Human Genetics, vol. 66, no. 6, pp. 625-636 . https://doi.org/10.1038/s10038-020-00895-6
J. Hum. Genet. 66, 625–636 (2021)
Crawford, A A, Bankier, S, Altmaier, E, Barnes, C L K, Clark, D W, Ermel, R, Friedrich, N, Van Der Harst, P, Joshi, P K, Karhunen, V, Lahti, J, Mahajan, A, Mangino, M, Nethander, M, Neumann, A, Pietzner, M, Sukhavasi, K, Wang, C A, Bakker, S J L, Björkegren, J L M, Campbell, H, Eriksson, J, Gieger, C, Hayward, C, Jarvelin, M-R, McLachlan, S, Morris, A P, Ohlsson, C, Pennell, C E, Price, J F, Rudan, I, Ruusalepp, A, Spector, T D, Tiemeier, H, Völzke, H, Wilson, J R M, Michoel, T, Timpson, N J, Davey Smith, G & Walker, B R 2021, ' Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease ', Journal of Human Genetics, vol. 66, no. 6, pp. 625-636 . https://doi.org/10.1038/s10038-020-00895-6
Journal of Human Genetics
Crawford, A, Bankier, S, Altmaier, E, Barnes, C L K, Clark, D W, Ermel, R, Friedrich, N, van der Harst, P, Joshi, P K, Karhunen, V, Lahti, J, Mahajan, A, Mangino, M, Nethander, M, Neumann, A, Pietzne, M, Sukhavasi, K, Wang, C A, Bakker, S J L, Björkegren, J L M, Campbell, H, Eriksson, J, Gieger, C, Hayward, C, Jarvelin, M-R, McLachlan, S, Morris, A P, Ohlsson, C, Pennell, C E, Price, J F, Rudan, I, Ruusalepp, A, Spector, T D, Tiemeier, H, Völzke, H, Wilson, J F, Michoel, T, Timpson, N J, Davey Smith, G & Walker, B R 2021, ' Variation in the SERPINA6SERPINA1 locusalters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expressionin peripheral tissues, and risk of cardiovascular disease ', Journal of Human Genetics . https://doi.org/10.1038/s10038-020-00895-6
Journal of human genetics, 66(6), 625-636. Nature Publishing Group
Journal of Human Genetics, 66(6), 625-636. Nature Publishing Group
Crawford, A A, Bankier, S, Altmaier, E, Barnes, C L K, Clark, D W, Ermel, R, Friedrich, N, Van Der Harst, P, Joshi, P K, Karhunen, V, Lahti, J, Mahajan, A, Mangino, M, Nethander, M, Neumann, A, Pietzner, M, Sukhavasi, K, Wang, C A, Bakker, S J L, Bjorkegren, J L M, Campbell, H, Eriksson, J, Gieger, C, Hayward, C, Jarvelin, M, Mclachlan, S, Morris, A P, Ohlsson, C, Pennell, C E, Price, J, Rudan, I, Ruusalepp, A, Spector, T, Tiemeier, H, Völzke, H, Wilson, J F, Michoel, T, Timpson, N J, Smith, G D & Walker, B R 2021, ' Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease ', Journal of Human Genetics, vol. 66, no. 6, pp. 625-636 . https://doi.org/10.1038/s10038-020-00895-6
J. Hum. Genet. 66, 625–636 (2021)
Crawford, A A, Bankier, S, Altmaier, E, Barnes, C L K, Clark, D W, Ermel, R, Friedrich, N, Van Der Harst, P, Joshi, P K, Karhunen, V, Lahti, J, Mahajan, A, Mangino, M, Nethander, M, Neumann, A, Pietzner, M, Sukhavasi, K, Wang, C A, Bakker, S J L, Björkegren, J L M, Campbell, H, Eriksson, J, Gieger, C, Hayward, C, Jarvelin, M-R, McLachlan, S, Morris, A P, Ohlsson, C, Pennell, C E, Price, J F, Rudan, I, Ruusalepp, A, Spector, T D, Tiemeier, H, Völzke, H, Wilson, J R M, Michoel, T, Timpson, N J, Davey Smith, G & Walker, B R 2021, ' Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease ', Journal of Human Genetics, vol. 66, no. 6, pp. 625-636 . https://doi.org/10.1038/s10038-020-00895-6
The stress hormone cortisol modulates fuel metabolism, cardiovascular homoeostasis, mood, inflammation and cognition. The CORtisol NETwork (CORNET) consortium previously identified a single locus associated with morning plasma cortisol. Identifying a
Autor:
Massimo Mangino, Christopher J Hammond, Tim D. Spector, Claire J. Steves, Cristina Menni, Caroline I. Le Roy, Richard Davies, Simon Couvreur, Frances M K Williams, Mario Falchi, Ruth C. E. Bowyer, Carole H. Sudre, Olatz Mompeo, Maxim B. Freidin, Alessia Visconti
Publikováno v:
Twin Research and Human Genetics
Susceptibility to infection such as SARS-CoV-2 may be influenced by host genotype. TwinsUK volunteers (n = 3261) completing the C-19 COVID-19 symptom tracker app allowed classical twin studies of COVID-19 symptoms, including predicted COVID-19, a sym
Autor:
Jordana T. Bell, Elizabeth Selvin, Cristina Menni, Caroline I. Le Roy, Jialing Zhu, Kari E. North, Eric Boerwinkle, Robert P. Mohney, Kristin L. Young, Olatz Mompeo, Ana M. Valdes, Massimo Mangino, Casey M. Rebholz, Tim D. Spector, Bing Yu
Publikováno v:
Gut Microbes, Vol 11, Iss 6, Pp 1632-1642 (2020)
Gut Microbes
article-version (VoR) Version of Record
Gut Microbes
article-version (VoR) Version of Record
Type 2 diabetes (T2D) is associated with reduced gut microbiome diversity, although the cause is unclear. Metabolites generated by gut microbes also appear to be causative factors in T2D. We therefore searched for serum metabolites predictive of gut
Autor:
Christopher A. Haiman, Laura D. Kubzansky, Brianna M. Leonardo, Walter C. Willett, Lynn Rosenberg, Alpa V. Patel, Denis Nash, Loic Le Marchand, Shepherd H. Schurman, A. Heather Eliassen, Laura Beane-Freeman, Jae H. Kang, Long H. Nguyen, Lynne R. Wilkens, Jacqueline J. Flynn, Mingyang Song, James V. Lacey, Irene M. Ghobrial, Annie Cowan, Marina V. Magicheva-Gupta, Tim D. Spector, Paul W. Franks, Dale P. Sandler, Roger L. Milne, Maria Elena Martinez, Sohee Kwon, Raaj S. Mehta, Lorelei A. Mucci, Jane C. Figueiredo, Catherine R. Marinac, Jaime E. Hart, Zahra S. Fatehi, Karestan C. Koenen, Amit Joshi, Jorge E. Chavarro, Sebastien Ourselin, Brenda Kirpach, Christine M. Albert, Shreela V. Sharma, Meir J. Stampfer, Wenjie Ma, Daniel Sikavi, Sandra Deming-Halverson, Andrew T. Chan, John S. Brownstein, Janet E. Hall, Bijal A. Balasubramanian, Anusila Deka, Janet W. Rich-Edwards, Chuan-Guo Guo, Claire J. Steves, Jonathan Wolf, Julie R. Palmer, Fiona Bruinsma, Gabriella Andreotti, Michael E. Ernst, Anne M. Murray, Chun-Han Lo, Christopher D. Gardner, David A. Drew
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention
The rapid pace of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; COVID-19) pandemic presents challenges to the real-time collection of population-scale data to inform near-term public health needs as well as future investigations. W
Autor:
Darioush Yarand, Ruth C. E. Bowyer, Paraskevi Christofidou, Cristina Menni, Jordana T. Bell, Genevieve Lachance, Serena Verdi, Kerrin S. Small, Deborah J. Hart, Massimo Mangino, Claire J. Steves, Golboo Abbasian, Tim D. Spector, Frances M K Williams, Mario Falchi, Christopher J Hammond
Publikováno v:
Twin Research and Human Genetics. 22:523-529
TwinsUK is the largest cohort of community-dwelling adult twins in the UK. The registry comprises over 14,000 volunteer twins (14,838 including mixed, single and triplets); it is predominantly female (82%) and middle-aged (mean age 59). In addition,
Autor:
Amrita Vijay, Stuart Astbury, Louca Panayiotis, Francine Z. Marques, Tim D. Spector, Cristina Menni, Ana M. Valdes
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Frontiers in Cardiovascular Medicine
Frontiers in Cardiovascular Medicine
Aims: The current study investigates the role of diet in mediating the gut microbiome-cardiovascular association which has not yet been explored in humans.Methods and Results: Using a two-arm dietary intervention study in healthy participants (N = 70