Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Nithya Ramnath"'
Autor:
C.A. Schonewolf, Christopher D. Lao, Ajjai Alva, Xueting Lang, Ilona Kryczek, Fengyun Su, Jiali Yu, Alangoya Tezel, Yilun Sun, Kyle C. Cuneo, Arul M. Chinnaiyan, Meredith A. Morgan, Syed Monem Rizvi, Linda Vatan, Issam El Naqa, Rohan K. Achar, Shuang Wei, Charles S. Mayo, Theodore S. Lawrence, Long Jiang, Wojciech Szeliga, Zoey Chopra, Nithya Ramnath, Weiping Zou, Sara Journey, Jiajia Zhou, Marcin Cieslik, Vincent T. Ma, Jae Eun Choi, Jeremy Skvarce, Xuhong Cao, Shasha Li, Fei Wen, Jessica Waninger, Yingjie Bian, Merna Sitto, Michael D. Green, Angel Qin, B.S. Rosen, Sathiya Pandi Narayanan
Publikováno v:
Nature Medicine. 27:152-164
Metastasis is the primary cause of cancer mortality, and cancer frequently metastasizes to the liver. It is not clear whether liver immune tolerance mechanisms contribute to cancer outcomes. We report that liver metastases diminish immunotherapy effi
Autor:
Nithya Ramnath, Theodore S. Lawrence, Derek J. Nancarrow, Guoan Chen, Wenbin Ji, Dipankar Ray, Paramita Ray, Stefanie Galbán, Alnawaz Rehemtulla, Wei Huang, Zhuwen Wang, David G. Beer
Publikováno v:
J Biol Chem
We previously reported that overexpression of cytochrome P450 family 24 subfamily A member 1 (CYP24A1) increases lung cancer cell proliferation by activating RAS signaling and that CYP24A1 knockdown inhibits tumor growth. However, the mechanism of CY
Autor:
Kiran H. Lagisetty, Chunfang Guo, Yali Li, Shuanying Yang, Wenmei Su, Andrew C. Chang, Jingyi Zhai, Pierre P. Massion, Hu Shan, Han Fu, Qianqian Geng, Zhuwen Wang, Guoan Chen, Jie Zhang, David G. Beer, Xiuyuan Chen, Nithya Ramnath, Jules Lin, Hui Jiang, Xia Yang
Publikováno v:
Translational Lung Cancer Research. 8:636-648
Background Our previous studies have identified a serum-based 4-microRNA (4-miRNA) signature that may help distinguish patients with lung cancer (LC) from non-cancer controls (NCs). Here, we used an extended independent cohort of 398 subjects to furt
Publikováno v:
Cancers, Vol 13, Iss 1476, p 1476 (2021)
Rearrangements in the Anaplastic Lymphoma Kinase (ALK) gene have been implicated in 5–6% of all non-small cell lung cancers. ALK-rearranged non-small cell lung cancers are sensitive to ALK-directed tyrosine kinase inhibitors, but generally resistan
Autor:
Yang Wang, Angel Qin, Tae Hyun Kim, Lili Zhao, Sunitha Nagrath, Theodore S. Lawrence, Zhuo Zhang, Shamileh Fouladdel, Payal D. Soni, Nithya Ramnath, Ebrahim Azizi, Kyle C. Cuneo
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Preclinical studies demonstrated that radiation up-regulates PD-L1 expression in tumor cells, providing a rationale for combining PD-1/PD-L1 inhibitors with radiation. However this has not been validated in patients with non-small cell lung cancer du
Autor:
Nithya Ramnath, Frank Weinberg
Publikováno v:
Translational Lung Cancer Research. 7:S243-S247
Somatic KRAS mutations are the most common oncogenic variants in lung cancer and are associated with poor prognosis. Using a Kras–induced lung cancer mouse model, CC-LR, we previously showed a role for inflammation in lung tumorigenesis through act
Autor:
Sunitha Nagrath, Nallasivam Palanisamy, Rishindra M. Reddy, Mina Zeinali, Bryan J. Schneider, Eric Lin, Max S. Wicha, Arthi Nadhan, Gregory P. Kalemkerian, Anvya Mathur, Lili Zhao, Khaled A. Hassan, Maggie Lee, Nithya Ramnath, Mathias Hafner, Casey Hedman, Ramdane Harouaka
Publikováno v:
Cancers, Vol 12, Iss 1, p 127 (2020)
Cancers
Volume 12
Issue 1
Cancers
Volume 12
Issue 1
(1) Background: Circulating tumor cell (CTC) clusters are emerging as clinically significant harbingers of metastases in solid organ cancers. Prior to engaging these CTC clusters in animal models of metastases, it is imperative for technology to iden
Autor:
Jessica Everett, Xuhong Cao, Jeffrey W. Innis, Rajen Mody, Francis P. Worden, Yi-Mi Wu, David Smith, Javed Siddiqui, Joseph Vijai, Erica Rabban, Moshe Talpaz, Kenneth Offit, Elena M. Stoffel, Daniel F. Hayes, J. Scott Roberts, Ajjai Alva, Chandan Kumar-Sinha, Erin F. Cobain, Robert J. Lonigro, Nithya Ramnath, Marcin Cieślik, Laurence H. Baker, David R. Lucas, Ann F. Schott, Dan R. Robinson, Mark M. Zalupski, Scott A. Tomlins, Victoria M. Raymond, Pankaj Vats, Arul M. Chinnaiyan, Scott M. Schuetze, Lakshmi P. Kunju, Rashmi Chugh
Publikováno v:
Nature
SUMMARY Metastasis is the primary cause of cancer-related deaths. While The Cancer Genome Atlas (TCGA) has sequenced primary tumor types obtained from surgical resections, much less comprehensive molecular analysis is available from clinically acquir
Autor:
Guoan Chen, Hiroe Shiratsuchi, Lili Zhao, Paramita Ray, Zhuwen Wang, Dipankar Ray, Zhuo Zhang, Nithya Ramnath, Jules Lin, David G. Beer
Publikováno v:
Journal of Thoracic Oncology. 12:269-280
Introduction We have previously demonstrated that a subset of lung cancer cells express higher CYP24A1 mRNA, a metabolizing enzyme for 1,25-D3, compared to benign tumors or surrounding normal lung and that high CYP24A1 mRNA expression is associated w
Publikováno v:
Journal of Thoracic Oncology. 12:397-402
The emergence of liquid biopsy using circulating tumor cells (CTCs) as a resource to identify genomic alterations in cancer presents new opportunities for diagnosis, therapy, and surveillance. We identified EML4-ALK gene rearrangement in expanded CTC