Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mengfan Tang"'
Autor:
Zhongming Zhao, Junjie Chen, Chao Wang, Zhen Chen, Mengfan Tang, Xu Feng, Dan Su, Guangsheng Pei, Mrinal Srivastava
Publikováno v:
Nucleic Acids Research
Poly (ADP-ribose) polymerase inhibitor (PARPi)-based therapies initially reduce tumor burden but eventually lead to acquired resistance in cancer patients with BRCA1 or BRCA2 mutation. To understand the potential PARPi resistance mechanisms, we perfo
Autor:
Min Huang, Dan Su, Xu Feng, Chao Wang, Traver Hart, Mengfan Tang, Gang Wang, Adriana Paulucci-Holthauzen, Junjie Chen
Publikováno v:
Oncogene
Aurora kinases are a family of serine/threonine kinases vital for cell division. Because of the overexpression of Aurora kinases in a broad range of cancers and their important roles in mitosis, inhibitors targeting Aurora kinases have attracted atte
Autor:
Chao Wang, Traver Hart, Klaudia Anna Szymonowicz, Dan Su, Xu Feng, Zhen Chen, Jeong Min Park, Mengfan Tang, Siting Li, Yun Xiong, Litong Nie, Junjie Chen, Huimin Zhang, Min Huang
Publikováno v:
Nucleic Acids Research
Because of essential roles of DNA damage response (DDR) in the maintenance of genomic integrity, cellular homeostasis, and tumor suppression, targeting DDR has become a promising therapeutic strategy for cancer treatment. However, the benefits of can
Autor:
Chao Wang, Megan McLaughlin, Gang Wang, Zhen Chen, Glen Traver Hart, Mengfan Tang, Xu Feng, Junjie Chen, Jie Zhang, Mrinal Srivastava, Peter Shepherd, Nora M. Navone
Publikováno v:
Oncogene
Ataxia telangiectasia mutated and RAD3 related (ATR) protein kinase plays critical roles in ensuring DNA replication, DNA repair, and cell cycle control in response to replication stress, making ATR inhibition a promising therapeutic strategy for can
Autor:
Litong Nie, Junjie Chen, Chao Wang, Zhen Chen, Mengfan Tang, Dan Su, Huimin Zhang, Yun Xiong, Xu Feng, Jeong Min Park
Publikováno v:
Oncogenesis
Oncogenesis, Vol 9, Iss 9, Pp 1-11 (2020)
Oncogenesis, Vol 9, Iss 9, Pp 1-11 (2020)
The ERK1/2 pathway is one of the most commonly dysregulated pathways in human cancers and controls many vital cellular processes. Although many ERK1/2 kinase substrates have been identified, the diversity of ERK1/2 mediated processes suggests the exi
Autor:
Siting Li, Junjie Chen, Huimin Zhang, Mengfan Tang, Zhongming Zhao, Chao Wang, Xu Li, Guangsheng Pei, Mrinal Srivastava, Zhen Chen, Xu Feng
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 108018-(2020)
Cell reports
Cell reports
SUMMARY 53BP1 plays a central role in dictating DNA repair choice between non-homologous end joining (NHEJ) and homologous recombination (HR), which is important for the sensitivity to poly(ADP-ribose) polymerase inhibitors (PARPis) of BRCA1-deficien
Autor:
Benjamin P C Chen, Zhou Songyang, Feng Li, Zepeng Zhang, Yong Zhao, Junjiu Huang, Wenbin Ma, Tianpeng Zhang, Shichuan Zhang, Yikang Rong, Qian Hu, Haiying Liu, Mengfan Tang
Publikováno v:
EMBO reports. 18:1412-1428
Repetitive DNA is prone to replication fork stalling, which can lead to genome instability. Here, we find that replication fork stalling at telomeres leads to the formation of t‐circle‐tails, a new extrachromosomal structure that consists of circ
Autor:
Haiying Liu, Jerry W. Shay, Yuanlong Ge, Wenbin Ma, Yong Zhao, Shengzhao Gong, Zepeng Zhang, Mengfan Tang, Woodring E. Wright, Qinfen Zhang, Tianpeng Zhang
Publikováno v:
The Journal of biological chemistry. 294(16)
Linear chromosome ends are capped by telomeres that have been previously reported to adopt a t-loop structure. The lack of simple methods for detecting t-loops has hindered progress in understanding the dynamics of t-loop formation and its function i
Autor:
Chao Wang, Nan Li, Mrinal Srivastava, Jong Min Choi, Cao-Qi Lei, Jun Qin, Junjie Chen, Zhen Chen, Sung Yun Jung, Huimin Zhang, Mengfan Tang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
AMP-activated protein kinase (AMPK) is a key regulator of cellular energy homeostasis. Although AMPK has been studied extensively in cellular processes, understanding of its substrates and downstream functional network, and their contributions to cel
Publikováno v:
Molecular & cellular proteomics : MCP, vol 15, iss 4
The mismatch repair (MMR) family is a highly conserved group of proteins that function in correcting base–base and insertion–deletion mismatches generated during DNA replication. Disruption of this process results in characteristic microsatellite