Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Margaret H Collins"'
Autor:
Natia Esiashvili, Edward F. Attiyeh, Peter Mattei, Susan L. Cohn, Wendy B. London, Arlene Naranjo, Araz Marachelian, Sheena C. Tenney, Mary Lou Schmidt, John M. Maris, E. Stanton Adkins, Katherine K. Matthay, Julie M. Gastier-Foster, Howard M. Katzenstein, Margaret H. Collins, Clare J. Twist, Julie R. Park, Michael H. Handler, Hiroyuki Shimada, Elizabeth Wagner, Michael D. Hogarty
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol 37, iss 34
J Clin Oncol
J Clin Oncol
PURPOSE The primary objective of the Children’s Oncology Group study ANBL0531 (ClinicalTrials.gov identifier: NCT00499616 ) was to reduce therapy for subsets of patients with intermediate-risk neuroblastoma using a biology- and response-based algor
Autor:
Amnah Yamani, Mark Rochman, Philip E. Putnam, Marc E. Rothenberg, Kavisha Arora, John A. Besse, Vincent A. Mukkada, Taeko K. Noah, Mirna Chehade, David Wu, Simone Vanoni, Julie M. Caldwell, Ting Wen, Chang Zeng, Simon P. Hogan, Margaret H. Collins, Lisa Waggoner, Justin C. Wheeler, Jazib Uddin, Anjaparavanda P. Naren
Publikováno v:
J Allergy Clin Immunol
Background Eosinophilic esophagitis (EoE) is characterized by histopathologic modifications of esophageal tissue, including eosinophil-rich inflammation, basal zone hyperplasia, and dilated intercellular spaces (DIS). The underlying molecular process
Autor:
Kathryn A. Peterson, Gary W. Falk, Neil Stahl, Yehudith Assouline-Dayan, Ikuo Hirano, Margaret H. Collins, George D. Yancopoulos, Neil M.H. Graham, Jennifer D. Hamilton, Allen Radin, Evan S. Dellon, Marc E. Rothenberg, Qiong Zhao, Mirna Chehade, Bolanle Akinlade, Zhen Chen, Brian N. Swanson, Gianluca Pirozzi, Alain M. Schoepfer, Leda Mannent, Ekaterina Safroneeva
Publikováno v:
Hirano, Ikuo; Dellon, Evan S; Hamilton, Jennifer D; Collins, Margaret H; Peterson, Kathryn; Chehade, Mirna; Schoepfer, Alain M; Safroneeva, Ekaterina; Rothenberg, Marc E; Falk, Gary W; Assouline-Dayan, Yehudith; Zhao, Qiong; Chen, Zhen; Swanson, Brian N; Pirozzi, Gianluca; Mannent, Leda; Graham, Neil M H; Akinlade, Bolanle; Stahl, Neil; Yancopoulos, George D; ... (2020). Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis. Gastroenterology, 158(1), pp. 111-122. Elsevier 10.1053/j.gastro.2019.09.042
BACKGROUND & AIMS Eosinophilic esophagitis (EoE) is an allergen-mediated inflammatory disease with no approved treatment in the United States. Dupilumab, a VelocImmune-derived human monoclonal antibody against the interleukin 4 (IL4) receptor, inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e64ac1a750f5e3f39a916ac979753e
https://boris.unibe.ch/133886/8/1-s2.0-S0016508519414157-main.pdf
https://boris.unibe.ch/133886/8/1-s2.0-S0016508519414157-main.pdf
Autor:
Ting Wen, Gary W. Falk, Seema S. Aceves, Nirmala Gonsalves, Christina L Carpenter, J. Pablo Abonia, Guang Yu Yang, John Leung, Vincent A. Mukkada, Margaret H. Collins, Dan Atkins, Ikuo Hirano, Marc E. Rothenberg, Sandeep K. Gupta, Nives Zimmermann, Michael P. Trimarchi, Paul Menard-Katcher, Kelley E. Capocelli, Jeffrey P. Krischer, Jonathan M. Spergel, Tetsuo Shoda, Michael D. Eby, Evan S. Dellon, Glenn T. Furuta, Julie M. Caldwell, Jonathan Kuhl, Peter A Bonis
Publikováno v:
The lancet. Gastroenterology & hepatology, vol 3, iss 7
BackgroundEosinophilic oesophagitis is understood in terms of quantifiable histological, endoscopic, and molecular features. Data are scant for inter-relations of these features and their potential to identify distinct disease endotypes. We aimed to
Autor:
Paul Menard-Katcher, Seema S. Aceves, Julia L M Dunn, Glenn T. Furuta, Jonathan M. Spergel, Amanda K. Rudman-Spergel, Tetsuo Shoda, Evan S. Dellon, Marc E. Rothenberg, Guang Yu Yang, Julie M. Caldwell, Lisa J. Martin, John Leung, Ting Wen, Gary W. Falk, Margaret H. Collins, Joshua B. Wechsler
Publikováno v:
J Allergy Clin Immunol
There is strong evidence for a role of type 2 cytokines in the pathogenesis of eosinophilic esophagitis (EoE); however, heterogeneity in type 2 gene expression has not been examined.We examined type 2 immunity-associated gene expression in esophageal
Autor:
Ryan Deaton, Sarah Harris, Cristian Rodriguez, Steven Y. Hua, Ikuo Hirano, Margaret H. Collins, Evan S. Dellon, Peter H. Gann, Nathan McMahon
Publikováno v:
The Journal of allergy and clinical immunology. 146(2)
Background Fibrostenosis, the most serious eosinophilic esophagitis (EoE) complication, is mediated by epithelial-mesenchymal transition (EMT). Transitioned cells contribute to pathogenesis by overproducing extracellular matrix. Objective Our aim was
Autor:
J. Pablo Abonia, Hanna Johansson, Gurjit K. Khurana Hershey, Joceyln M. Biagini Myers, Lisa J. Martin, Hua He, Margaret H. Collins, Michael D. Eby, Marc E. Rothenberg, Leah C. Kottyan
Publikováno v:
Journal of Allergy and Clinical Immunology. 141:1690-1698
BACKGROUND: Eosinophilic esophagitis (EoE) is an esophageal inflammatory disease associated with atopic diseases. Thymic stromal lymphopoietin (TSLP) and calpain 14 (CAPN14) genetic variations contribute to EoE, but how this relates to atopy is uncle
Autor:
Susan S. Baker, Melanie Schirmer, Alison Marquis, Joel R. Rosh, Cary G. Sauer, Laura Bauman, Mason Nistel, Phillip J. Dexheimer, James Markowitz, Kevin P. Mollen, Sapana Shah, Neal S. Leleiko, Anne M. Grifiths, Paul A. Rufo, Robert N. Baldassano, Rebekah Karns, Elizabeth Novak, Ashish S. Patel, Melvin B. Heyman, Judith Somekh, Yael Haberman, Erin Bonkowski, Ingrid Jurickova, Thomas D. Walters, Brendan M. Boyle, Tzipi Braun, Nathan Gotman, Angela Mo, Jeffrey S. Hyams, Curtis Huttenhower, Sonia Davis Thomas, Subra Kugathasan, Ramnik J. Xavier, Lee A. Denson, Marian D. Pfefferkorn, Greg Gibson, Joshua D. Noe, Bruce J. Aronow, Michael J. Rosen, Shai S. Shen-Orr, Margaret H. Collins, David R. Mack
Publikováno v:
Nature communications, vol 10, iss 1
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene expression, and fecal microbiota profiles, in 206 pediatric UC patients re
Autor:
Vincent A. Mukkada, Chang Zeng, Mirna Chehade, Sahiti Marella, Ting Wen, P.E. Putnam, Marc E. Rothenberg, Jason R. Spence, Catherine Ptaschinski, Anjaparavanda P. Naren, Artem Barski, Mark Rochman, Jianwen Que, Kavisha Arora, Simon P. Hogan, Taeko K. Noah, Lisa Waggoner, Lisa J. Martin, Jazib Uddin, Simone Vanoni, David Wu, Andrey V. Kartashov, Margaret H. Collins
Publikováno v:
J Allergy Clin Immunol
Background The pathology of eosinophilic esophagitis (EoE) is characterized by eosinophil-rich inflammation, basal zone hyperplasia (BZH), and dilated intercellular spaces, and the underlying processes that drive the pathologic manifestations of the
Autor:
Paul A. Frohna, Caiyan Li, Alex Straumann, Margaret H. Collins, Michael Grimm, Richard Aranda, Marc E. Rothenberg, Sandeep K. Gupta, Ikuo Hirano, Sheila Gujrathi, Larry Evans, Amy Woo, Cindy-ann Tompkins, Allan Olson, Ekaterina Safroneeva, Gregory J. Opiteck, Yehudith Assouline-Dayan, Heather Smith, Evan S. Dellon, Robert Peach, Darryl Penenberg, Alain M. Schoepfer
Publikováno v:
Gastroenterology, vol. 156, no. 3, pp. 592-603.e10
Hirano, Ikuo; Collins, Margaret H; Assouline-Dayan, Yehudith; Evans, Larry; Gupta, Sandeep; Schoepfer, Alain M; Straumann, Alex; Safroneeva, Ekaterina; Grimm, Michael; Smith, Heather; Tompkins, Cindy-Ann; Woo, Amy; Peach, Robert; Frohna, Paul; Gujrathi, Sheila; Penenberg, Darryl N; Li, Caiyan; Opiteck, Gregory J; Olson, Allan; Aranda, Richard; ... (2019). RPC4046, a Monoclonal Antibody Against IL13, Reduces Histologic and Endoscopic Activity in Patients With Eosinophilic Esophagitis. Gastroenterology, 156(3), 592-603.e10. Elsevier 10.1053/j.gastro.2018.10.051
Hirano, Ikuo; Collins, Margaret H; Assouline-Dayan, Yehudith; Evans, Larry; Gupta, Sandeep; Schoepfer, Alain M; Straumann, Alex; Safroneeva, Ekaterina; Grimm, Michael; Smith, Heather; Tompkins, Cindy-Ann; Woo, Amy; Peach, Robert; Frohna, Paul; Gujrathi, Sheila; Penenberg, Darryl N; Li, Caiyan; Opiteck, Gregory J; Olson, Allan; Aranda, Richard; ... (2019). RPC4046, a Monoclonal Antibody Against IL13, Reduces Histologic and Endoscopic Activity in Patients With Eosinophilic Esophagitis. Gastroenterology, 156(3), 592-603.e10. Elsevier 10.1053/j.gastro.2018.10.051
Eosinophilic esophagitis (EoE) is a chronic, esophageal, type 2 inflammatory response associated with increased serum levels of interleukin 13 (IL13), which might contribute to its pathogenesis. RPC4046, a recombinant humanized monoclonal antibody ag