Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Kyle, K."'
Autor:
Michael Ophir, Qianqian Ming, Gunjan Mandal, Evgenii N. Tcyganov, Carmen M. Anadon, Alfredo Perales-Puchalt, Jennifer Walrath, Michael Schmidt, Paulo C. Rodriguez, Ugur Eskiocak, Carly M. Harro, Douglas C. Marchion, Jessica A. Mine, Ricardo A. Chaurio, Juan R. Cubillos-Ruiz, Subir Biswas, Julia Tchou, Kristen E. Rigolizzo, Brooke T. Mclaughlin, Jose R. Conejo-Garcia, Jason Lajoie, Dmitry I. Gabrilovich, Andrea L. Buras, Piotr Bobrowicz, Tara Lee Costich, Vincent C. Luca, Kyle K. Payne
Publikováno v:
Science. 369:942-949
Gamma delta (γδ) T cells infiltrate most human tumors, but current immunotherapies fail to exploit their in situ major histocompatibility complex-independent tumoricidal potential. Activation of γδ T cells can be elicited by butyrophilin and buty
Autor:
Lewis C. Cantley, Nileeka Balasuriya, Shawn S.-C. Li, Patrick O'Donoghue, Huadong Liu, Jared L. Johnson, Kyle K. Biggar, Norman E. Davey
Publikováno v:
J Biol Chem
Paediatrics Publications
Paediatrics Publications
Protein kinase B (AKT1) is a central node in a signaling pathway that regulates cell survival. The diverse pathways regulated by AKT1 are communicated in the cell via the phosphorylation of perhaps more than 100 cellular substrates. AKT1 is itself ac
Autor:
Bahram Samanfar, Kyle K. Biggar, Ashkan Golshani, Andrew Schoenrock, Mohsen Hooshyar, Kevin Dick, James R. Green, Matthew Jessulat, Mohan Babu, Tom Kazmirchuk, Prabh Basra, Frank Dehne, Alex Wong, Daniel Burnside, Maryam Hajikarimlou, Sylvain Pitre, Brad Barnes, Houman Moteshareie
Publikováno v:
iScience, Vol 11, Iss, Pp 375-387 (2019)
iScience
iScience
Summary Synthetic proteins with high affinity and selectivity for a protein target can be used as research tools, biomarkers, and pharmacological agents, but few methods exist to design such proteins de novo. To this end, the In-Silico Protein Synthe
Publikováno v:
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
Autor:
Nancy G. Klimas, Leonor Sarria, Tali Finger, Oskar Zarnowski, Fanny Collado, Melanie Perez, Kyle K. Hansotia, Mary A Fletcher, Sean Riegle, Lubov Nathanson, Derek J. Van Booven
Publikováno v:
Life sciences. 281
Aims In an effort to gain further insight into the underlying mechanisms tied to disease onset and progression of Gulf War Illness (GWI), our team evaluated GWI patient response to stress utilizing RNA-Seq. Main Methods The protocol included blood co
Autor:
Subir Biswas, Tara Lee Costich, Jairo Perez-Sanz, Kimberly B. Sprenger, Jose R. Conejo-Garcia, Paulo C. Rodriguez, Xiaoqing Yu, Gunjan Mandal, Lubomir Sokol, Kristen E. Rigolizzo, Kebin Liu, Jessica A. Mine, Javier Pinilla-Ibarz, Ricardo A. Chaurio, Kyle K. Payne, Carmen M. Anadon, Louise C. Showe, Carly M. Harro
Publikováno v:
J Clin Invest
Cutaneous T cell lymphoma (CTCL) has a poorly understood etiology and no known cure. Using conditional knockout mice, we found that ablation of the genomic organizer special AT-rich sequence–binding protein 1 (Satb1) caused malignant transformation
Autor:
Kyle K. Payne
Publikováno v:
Semin Cancer Biol
Recurrent disease after prolonged cancer dormancy is a major cause of cancer associated mortality, yet many of the mechanisms that are engaged to initiate dormancy as well as later recurrence remain incompletely understood. It is known that cancer ce
Publikováno v:
Frontiers in Genetics
Frontiers in Genetics, Vol 11 (2020)
Frontiers in Genetics, Vol 11 (2020)
Oxygen sensing is inherent among most animal lifeforms and is critical for organism survival. Oxygen sensing mechanisms collectively trigger cellular and physiological responses that enable adaption to a reduction in ideal oxygen levels. The major me
Autor:
Jenica H. Kakadia, Madhulika B. Gupta, Cun Li, Peter W. Nathanielsz, Karen Nygard, Austen Sutherland, Kyle K. Biggar, Thomas Jansson, Bhawani Jain
Publikováno v:
Am J Physiol Endocrinol Metab
Paediatrics Publications
Paediatrics Publications
In cultured fetal liver cells, insulin-like growth factor (IGF) binding protein (IGFBP)-1 hyperphosphorylation in response to hypoxia and amino acid deprivation is mediated by inhibition of mechanistic target of rapamycin (mTOR) and activation of ami
Autor:
Anand Chopra, Yasser B. Ruiz-Blanco, Kristin Frensemier, Christopher Wynder, William L. Stanford, Qi Fang, James R. Green, Huadong Liu, Matthew Hoekstra, Shawn S.-C. Li, Justin Connolly, Francois Charih, Marek Galka, Hemanta Adhikary, Leanne Stalker, Kyle K. Biggar
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107896-(2020)
Protein Lys methylation plays a critical role in numerous cellular processes, but it is challenging to identify Lys methylation in a systematic manner. Here we present an approach combining in silico prediction with targeted mass spectrometry (MS) to