Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Keun-Wook Lee"'
Autor:
Bhumsuk Keam, Keon Uk Park, Hye Ryun Kim, Keun-Wook Lee, Sung-Bae Kim, Seong Hoon Shin, Jin-Hyuk Choi, Eun Joo Kang, Yun-Gyoo Lee, Hyo Jung Kim, Min Kyoung Kim, Hwan Jung Yun, Kyoung Eun Lee, Jin-Soo Kim, Hee Kyung Ahn
Publikováno v:
Cancer Research and Treatment : Official Journal of Korean Cancer Association
Purpose Certain patient subgroups who do not respond to induction chemotherapy (IC) show inherent chemoresistance in locally advanced head and neck squamous cell carcinoma (LA-HNSCC). This study aimed to assess the prognostic value of IC, and role of
Autor:
Yeon Joo Choi, Jinseu Park, Dae Won Kim, Hyeon Ji Yeo, Eun Jeong Sohn, Sung-Woo Cho, Jong Kook Park, Kyu Hyung Han, Duk-Soo Kim, Soo Young Choi, Keun Wook Lee, Hyun Jung Kwon, Won Sik Eum, Eun Ji Yeo, Min Jea Shin
Publikováno v:
Biomolecules & Therapeutics
Oxidative stress plays a crucial role in the development of neuronal disorders including brain ischemic injury. Thioredoxin 1 (Trx1), a 12 kDa oxidoreductase, has anti-oxidant and anti-apoptotic functions in various cells. It has been highly implicat
Autor:
Hye Ryun Kim, Hyun Chang, Keun-Wook Lee, Myung-Ju Ahn, Seong Hoon Shin, Ho Jung An, Sung-Bae Kim, Sang Hoon Chun, Yun-Gyoo Lee, Ji Hyun Park, Kyoung Eun Lee, In Gyu Hwang, Keon Uk Park, Bhumsuk Keam
Publikováno v:
Cancer Research and Treatment : Official Journal of Korean Cancer Association
Purpose This study was conducted to determine the effectiveness of immune checkpoint inhibitors (ICIs) in recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) after platinum-containing chemotherapy. We also identified clinical bi
Autor:
Philip J. Gold, Jan K Davidson-Moncada, Keun-Wook Lee, Yeul Hong Kim, Jon M. Wigginton, Minori Koshiji Rosales, Se Hoon Park, Rosalyn A. Juergens, Haeseong Park, Hope E. Uronis, Cheng Ean Chee, Yee Chao, Daniel V.T. Catenacci, Aleksandra Franovic, Yoon-Koo Kang, Jeffrey L. Nordstrom, Kristen A. Marrone, Eun-Kee Song, Jill Lacy, Sunnie Kim, Johanna C. Bendell, Sang Cheul Oh, Matthew C.H. Ng, Ronan J. Kelly, Jennifer Yen, Jong Gwang Kim, Keith L. Knutson, Yung-Jue Bang, A. Craig Lockhart, Howard S. Hochster, Daner Li, Thierry Alcindor, Sun Jin Sym, Peter C. Enzinger
Publikováno v:
The Lancet Oncology. 21:1066-1076
Summary Background Margetuximab, a novel, investigational, Fc-engineered, anti-HER2 monoclonal antibody, is designed to more effectively potentiate innate immunity than trastuzumab. We aimed to evaluate the safety, tolerability, and antitumour activi
Autor:
Narikazu Boku, Shigenori Kadowaki, Min Hee Ryu, Hiroki Hara, Ichinosuke Hyodo, Keun Wook Lee, Keisho Chin, Yoshinori Miyata, Sang Cheul Oh, Se Hoon Park, Masahiro Tsuda, Yung-Jue Bang, Norisuke Nakayama, Hyun Cheol Chung, Ik Joo Chung, Yoon-Koo Kang, Hideo Baba, Shuichi Hironaka, Hisashi Hosaka
Publikováno v:
The Lancet Oncology. 21:1045-1056
Summary Background S-1 plus leucovorin and oxaliplatin showed promising efficacy for treatment of advanced gastric cancer in a randomised phase 2 study. We aimed to evaluate the efficacy and safety of oral TAS-118 (S-1 plus leucovorin) and oxaliplati
Autor:
Hee Kyung Ahn, Eun Joo Kang, Seong Hoon Shin, Sung-Bae Kim, Y. Lee, Keon Uk Park, Jung Hye Kwon, Kyoung Eun Lee, Keun Wook Lee, Hwan Jung Yun, Hye Ryun Kim, Min Kyoung Kim, Jin-Soo Kim, Jin-Hyuk Choi, Bhumsuk Keam
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)
BMC Cancer
BMC Cancer
Background By investigating treatment patterns and outcomes in locally advanced head and neck squamous cell carcinoma (LA-HNSCC), we aimed at providing valuable insights into the optimal therapeutic strategy for physicians in real-world practice. Met
Autor:
Yujun Park, Jiwon Koh, Hee Young Na, Hyung Ho Kim, Hye Seung Lee, Yoonjin Kwak, Do Joong Park, Keun Wook Lee, Sang Hoon Ahn
Publikováno v:
Cancer Research and Treatment : Official Journal of Korean Cancer Association
Purpose We provide a comparison between 22C3 pharmDx and SP263 assay, for evaluating programmed death ligand 1 (PD-L1) expression in advanced gastric cancer (GC) patients.Materials and Methods The PD-L1 immunohistochemistry by 22C3 pharmDx and SP263
Autor:
Yee Chao, Siddharth Sheth, Judson M. Englert, Yung-Jue Bang, Michael K. Gibson, Cheng Ean Chee, Ronan J. Kelly, Hyun Cheol Chung, Zev A. Wainberg, Jeeyun Lee, Peng He, Johanna C. Bendell, Rom Leidner, Philip Z Brohawn, Jennifer McDevitt, Mariela Blum-Murphy, Keun Wook Lee, Takeshi Omori, Heinz-Josef Lenz, Geoffrey Y. Ku, Crystal S. Denlinger, Daniel V.T. Catenacci, Marlon Rebelatto, Khaldoun Almhanna
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 26, iss 4
Clin Cancer Res
Clin Cancer Res
Purpose: This randomized, multicenter, open-label, phase Ib/II study assessed durvalumab and tremelimumab in combination or as monotherapy for chemotherapy-refractory gastric cancer or gastroesophageal junction (GEJ) cancer. Patients and Methods: Sec
Autor:
Li-Tzong Chen, Hiroki Sameshima, Li Yuan Bai, Takao Tamura, Min Hee Ryu, Narikazu Boku, Do Youn Oh, Masahiro Tsuda, Keisho Chin, Yee Chao, Taroh Satoh, Keun Wook Lee, Takaki Yoshikawa, Keiko Minashi, Hyun Cheol Chung, Kun-Huei Yeh, Jae Yong Cho, Sang Cheul Oh, Jong Gwang Kim, Won Ki Kang, Ken Kato, Yasuo Hamamoto, Kei Muro, Yoon-Koo Kang, Jen-Shi Chen
Publikováno v:
Gastric Cancer. 23:510-519
Background Nivolumab showed improvement in overall survival (OS) in ATTRACTION-2, the first phase 3 study in patients with gastric/gastroesophageal junction (G/GEJ) cancer treated with ≥ 2 chemotherapy regimens. The 2-year follow-up results of ATTR
Autor:
Sun Young Kim, Chang Sik Yu, Jong Hoon Kim, Ji Sung Lee, Tae-You Kim, Jeong Eun Kim, Ji Yeon Baek, Joon Oh Park, Seong Hyeon Yun, Kyung Hae Jung, Joong Bae Ahn, Keun Wook Lee, Byung-Ho Nam, Kyu Pyo Kim, Young Suk Park, Seok Byung Lim, Hee Chul Park, Jin-Hong Park, Yong Sang Hong, Jin Cheon Kim, Tae Won Kim
Publikováno v:
Journal of Clinical Oncology. 37:3111-3123
PURPOSE We evaluated the role of oxaliplatin as adjuvant chemotherapy in patients with rectal cancer who received preoperative chemoradiotherapy (CRT) with fluoropyrimidine monotherapy and total mesorectal excision (TME). METHODS The ADORE trial (adj