Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Karel Souček"'
Publikováno v:
Cancers
Cancers, Vol 13, Iss 2188, p 2188 (2021)
Cancers, Vol 13, Iss 2188, p 2188 (2021)
Simple Summary Epithelial–mesenchymal transition (EMT) and its reverse process mesenchymal–epithelial transition (MET) are considered critical events in the cancer progression. These programs are tightly connected with the development of metastas
Autor:
Herbert Waldmann, Jana Flegel, Slava Ziegler, Barbora Valčíková, Stjepan Uldrijan, Sonja Sievers, Michaela Hylsová, Apirat Chaikuad, Stefan Knapp, Benedict-Tilman Berger, Lukáš Maier, Martin Schröder, Vaclav Nemec, Karel Souček, Stanislav Drápela, Kamil Paruch
Publikováno v:
Angewandte Chemie International Edition. 58:1062-1066
Reported is the identification of the furo[3,2-b]pyridine core as a novel scaffold for potent and highly selective inhibitors of cdc-like kinases (CLKs) and efficient modulators of the Hedgehog signaling pathway. Initially, a diverse target compound
Autor:
Ján Remšík, Aleš Hampl, Lucia Binó, Eva Slabáková, Karel Souček, Zuzana Kahounová, Daniela Kurfűrstová, Volodymyr Porokh, Radek Fedr, Vladimír Študent, Jan Bouchal, Radek Vrtěl, Lucie Jurečková
Publikováno v:
Stem Cell Research, Vol 33, Iss, Pp 255-259 (2018)
A human induced pluripotent stem cell line was generated from cancer-associated fibroblasts of a 68-years old patient with diagnosed prostate adenocarcinoma (PCa). The fibroblast cell line was reprogrammed with Epi5™ Episomal iPSC Reprogramming Kit
Autor:
Lucie Jurečková, Veronika Pospíšilová, Petr Vaňhara, Aleš Hampl, Zuzana Holubcová, Vendula Pelková, Daniela Mináriková, Tomáš Bárta, Karel Souček, Dáša Bohačiaková, Volodymyr Porokh
Publikováno v:
Stem Cells and Development. 27:1077-1084
Chromosomal instability evoked by abnormalities in centrosome numbers has been traditionally considered as a hallmark of aberrant, typically cancerous or senescent cells. We have reported previously that pristine human embryonic stem cells (hESC) suf
Publikováno v:
Cancers
Cancers, Vol 12, Iss 3227, p 3227 (2020)
Cancers, Vol 12, Iss 3227, p 3227 (2020)
Simple Summary Toll-like receptor 3 (TLR3) is a member of the TLR family, which has been extensively studied for the antiviral function and, therefore, its role in the innate and adaptive immune responses. It is highly expressed in the endosomes of a
Autor:
Zuzana Kahounová, Karel Souček, Jan Bouchal, Ján Remšík, Radek Fedr, Eva Slabáková, Lucia Binó, Alena Mickova, Aleš Hampl
Publikováno v:
Stem Cell Research, Vol 46, Iss, Pp 101844-(2020)
Deciphering the properties of adult stem cells is crucial for understanding of their role in healthy tissue and in cancer progression as well. Both stem cells and cancer stem cells have shown association with epithelial-to-mesenchymal transition (EMT
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences
The predominant way in which conventional chemotherapy kills rapidly proliferating cancer cells is the induction of DNA damage. However, chemoresistance remains the main obstacle to therapy effectivity. An increasing number of studies suggest that ep
Publikováno v:
Cytometry Part A. 93:239-248
Complex analysis of cellular responses after experimental treatment is important for screening, mechanistic understanding of treatment effects, and the identification of sensitive and resistant cell phenotypes. Modern multicolor flow cytometry has de
Autor:
Vladimír Študent, Zuzana Kahounová, Jan Bouchal, Alois Kozubík, Karel Souček, Gvantsa Kharaishvili, Ján Remšík, Daniela Kurfürstová, Šárka Šimečková, Jiří Navrátil
Publikováno v:
Cytometry Part A. 93:941-951
The identification of fibroblasts and cancer-associated fibroblasts from human cancer tissue using surface markers is difficult, especially because the markers used currently are usually not expressed solely by fibroblasts, and the identification of
Autor:
Zuzana Kahounová, Petr Beneš, Ján Remšík, Jiřina Procházková, Jan Bouchal, Tereza Suchankova, Gvantsa Kharaishvili, Karel Souček, Milan Král, Radek Fedr, Eva Slabáková, Šárka Šimečková
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Skp2 is a crucial component of SCFSkp2 E3 ubiquitin ligase and is often overexpressed in various types of cancer, including prostate cancer (PCa). The epithelial-to-mesenchymal transition (EMT) is involved in PCa progression. The acquisition of a mes