Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Julie Lee"'
Autor:
Giuseppe Terracina, Jerry P. Melchor, Cyrille Sur, David Kinsley, Lynn A. Hyde, Harold G. Selnick, Joseph L. Duffy, Jacob Marcus, Lili Zhang, Xiangjun Meng, Michelle Pearson, Xiaohai Wang, J. Fred Hess, David J. Vocadlo, Kwok-Lam Karen Hong, Julie Lee, Jason M. Uslaner, Daniel Rubins, Sherry X. Lu, Ernest J. McEachern, Sean M. Smith, Karen M. Smith, Wenping Li, Joel B. Schachter, Shu-Cheng Chen, Lixin Song, Eric D. Hostetler
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 374:252-263
Deposition of hyperphosphorylated and aggregated tau protein in the central nervous system is characteristic of Alzheimer disease and other tauopathies. Tau is subject to O-linked N-acetylglucosamine (O-GlcNAc) modification, and O-GlcNAcylation of ta
Autor:
Laurence Fayadat-Dilman, Christine Andrews, Gulesi Ayanoglu, Liming Liu, Robert A. Kastelein, Aarron T. Willingham, Sabine Le Saux, Svetlana Sadekova, Dan Malashock, Hans van Eenennaam, Sophie Li, Ying Yu, Soonmo Peter Kang, Beth Hutchins, Andrea van Elsas, John Dulos, Rene De Waal Malefyt, Julie Lee, Frederique M. Poulet, Gregory J. Carven, Constance Cullen, Gary C. Starling, Mark Hsieh, Danuta J. Herzyk, Michel Streuli, Mark A. McCoy, George Soder
Publikováno v:
Molecular Cancer Therapeutics. 19:1298-1307
The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint, which may be engaged by cells in the tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®, MK-3475) is a potent and highly sel
Autor:
Julie Lee, Lewis Tomalin, Hernan Valdez, James G. Krueger, Mayte Suárez-Fariñas, Gabriel Berstein, Robert Wolk, Jae Hwan Kim, Lori Fitz, Joel Correa da Rosa
Publikováno v:
Journal of Investigative Dermatology. 140:1026-1034
The application of machine learning to longitudinal gene-expression profiles has demonstrated potential to decrease the assessment gap, between biochemical determination and clinical manifestation, of a patient’s response to treatment. Although pso
Autor:
Caitlin R. Jarman, Jing Lei, J. Kelley Bentley, Julie Lee, Charu Rajput, Tomoko Ishikawa, Marc B. Hershenson, Adam M. Goldsmith, Mingyuan Han, Jennifer Bermick
Publikováno v:
Allergy
Background Early-life wheezing-associated respiratory infection with human rhinovirus (RV) is associated with asthma development. RV infection of 6-day-old immature mice causes mucous metaplasia and airway hyperresponsiveness which is associated with
Autor:
Caitlin R. Jarman, Toby C. Lewis, Jing Lei, Marc B. Hershenson, Charu Rajput, J. Kelley Bentley, Tomoko Ishikawa, Mark J. Hoenerhoff, Mingyuan Han, Julie Lee, Adam M. Goldsmith, William T. Jackson
Publikováno v:
Mucosal Immunol
Activation of the inflammasome is a key function of the innate immune response that regulates inflammation in response to microbial substances. Inflammasome activation by human rhinovirus (RV), a major cause of asthma exacerbations, has not been well
Autor:
Mina Hassan-Zahraee, Michael S. Vincent, Julie Lee, Mateusz Maciejewski, Vivek Pradhan, Shanrong Zhao, Yutian Zhan, David von Schack, Huanyu Zhou, Kenneth J. Gorelick, Zachary S. Stewart, Lori Fitz, Shawn P. O'Neil, Ying Zhang, Austin Huang, Li Xi, Karen Page, Kenneth E. Hung, Daniel Ziemek, Fabio Cataldi, Baohong Zhang
Publikováno v:
Journal of Crohn's & Colitis
Background and Aims To define pharmacodynamic and efficacy biomarkers in ulcerative colitis [UC] patients treated with PF-00547659, an anti-human mucosal addressin cell adhesion molecule-1 [MAdCAM-1] monoclonal antibody, in the TURANDOT study. Method
Autor:
Honghui Lin, Zhensheng Kang, Sonny Lee Van, Bo Liu, Yuh-Ru Julie Lee, Hongchang Zhang, Baojuan Sun, Xingguang Deng
Publikováno v:
Nature Plants. 4:485-494
The evolutionarily conserved WD40 protein budding uninhibited by benzimidazole 3 (BUB3) is known for its function in spindle assembly checkpoint control. In the model plant Arabidopsis thaliana, nearly identical BUB3;1 and BUB3;2 proteins decorated t
Publikováno v:
Molecular plant, vol 10, iss 11
Probing protein-protein interaction has become a routine practice in the post genomic era. Multiple in vitro or in vivo techniques have been developed to detect or report direct or indirect interactions of functionally related proteins (Lalonde et al
Autor:
David von Schack, Angela Hadjipanayis, Weidong Zhang, Mateusz Maciejewski, Xing Chen, Daniel Ziemek, Julie Lee, Lori Fitz, David Martin, Shanrong Zhao, Craig L. Hyde
Publikováno v:
Poster Presentations.
Background The Janus kinase (JAK) family of tyrosine kinases includes JAK1, JAK2, JAK3 and TYK2 which signals through type I and type II cytokine receptors. Tofacitinib is an oral JAK inhibitor approved for the treatment of rheumatoid arthritis (RA).
Autor:
Craig L. Hyde, David Martin, Tomohiro Hirose, Julie Lee, Weidong Zhang, Lori Fitz, Xing Chen, Shweta Shah
Publikováno v:
Abstracts Accepted for Publication.
Background: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. Herpes zoster is more common in patients (pts) with RA vs the general population.1 This risk increases with tofacitinib use2 and appears to be further increased with c