Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Huaxin Sheng"'
Autor:
Huaxin Sheng, Jingjun Lyu, Francesca Galeffi, Dennis A. Turner, Wulf Paschen, Zhuoran Wang, Joshua D. Bernstock, Yuntian Shen, Shu Yu, Shuai Liu, Wei Yang, Ramona M. Rodriguiz, Kory R. Johnson, Ran Li, William C. Wetsel
Publikováno v:
FASEB J
Small ubiquitin-like modifier (SUMO1–3) conjugation (SUMOylation), a post-translational modification, modulates almost all major cellular processes. Mounting evidence indicates that SUMOylation plays a crucial role in maintaining and regulating neu
Autor:
Zhuoran Wang, Wei Wang, Wei Yang, Xuan Li, Weiguo Zhang, Maorong Jiang, Huaxin Sheng, Jingjun Lyu, Ran Li, Jörn Karhausen
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-12 (2020)
Journal of Neuroinflammation
Journal of Neuroinflammation
BackgroundCardiac arrest (CA) is associated with high morbidity and mortality, even after spontaneous circulation is re-established. This dire situation is partly due to post-CA syndrome for which no specific and effective intervention is available.
Autor:
Zhiqing Huang, Ines Batinic-Haberle, Zhipeng Cao, Li Du, Huaxin Sheng, Weina Duan, Ivan Spasojevic, Angeles Alvarez Secord, Sharareh Siamakpour-Reihani, Artak Tovmasyan
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Mn(III) ortho-N-alkyl- and N-alkoxyalkyl porphyrins (MnPs) were initially developed as superoxide dismutase (SOD) mimics. These compounds were later shown to react with numerous reactive species (such as ONOO-, H2O2, H2S, CO3•-, ascorbate, and GSH)
Autor:
Ivan Spasojevic, Bin Xu, Romulo S. Sampaio, David S. Warner, Ines Batinic-Haberle, Huaxin Sheng, Artak Tovmasyan, Litao Li, Júlio S. Rebouças
Publikováno v:
Antioxidants, Vol 9, Iss 467, p 467 (2020)
Antioxidants
Volume 9
Issue 6
Antioxidants
Volume 9
Issue 6
Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, (H2O)MnTnHex-2-PyP5+ (MnHex) carrying long hexyl chains, is a lipophilic mimic of superoxide dismutase (SOD) and a redox-active drug candidate. MnHex crosses the blood&ndash
brain barrier
brain barrier
Autor:
Huaxin Sheng, Yanxia Tian, Ying Cui, Wen-Yuan Ling, Junling Gao, Kaijie Wang, Jianzhong Cui, Xiaohua Jiang
Publikováno v:
Biochemical and biophysical research communications. 527(1)
Acute spontaneous intracerebral hemorrhage (ICH) is a life-threatening disease. It is often accompanied by severe neurological sequelae largely caused by the loss of integrity of the neural circuits. However, these neurological sequelae have few stro
Autor:
Huaxin Sheng, Ying Li, Zhui Yu, Wei Yang, Meng Jiang, Shuai Liu, David S. Warner, Shu Yu, Wulf Paschen
Publikováno v:
Stroke. 48:1646-1654
Background and Purpose— Impaired protein homeostasis induced by endoplasmic reticulum dysfunction is a key feature of a variety of age-related brain diseases including stroke. To restore endoplasmic reticulum function impaired by stress, the unfold
Autor:
Huaxin Sheng, Ying Li, Wulf Paschen, Xiaozhi Liu, Shuai Liu, David S. Warner, Lin Zhang, Wei Yang, Julia Q. Zhao
Publikováno v:
Neuroscience. 343:190-212
Small ubiquitin-like modifier (SUMO) conjugation (SUMOylation) plays key roles in neurologic function in health and disease. Neuronal SUMOylation is essential for emotionality and cognition, and this pathway is dramatically activated in post-ischemic
Autor:
Kaijie Wang, Huaxin Sheng, Yanxia Tian, Junling Gao, Changmeng Cui, Jianzhong Cui, Xiaohua Jiang, Ran Li, Ying Cui
Publikováno v:
Cellular Physiology and Biochemistry, Vol 42, Iss 1, Pp 137-144 (2017)
Background/Aims: Intracerebral hemorrhage (ICH) occurs in hypertensive patients and results in high rates of mortality and disability. This study determined whether bone marrow mesenchymal stem cell (BMSC) transplantation affects axonal regeneration
Autor:
Steven D. Crowley, Yuntian Shen, Jiafa Ren, Fei Ding, Baihui Yan, Qiang Zhao, Wei Wang, Shu Yu, Zhuoran Wang, Wei Yang, Huaxin Sheng, Wulf Paschen, Jiangbo Wu
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The mechanisms underlying worse outcome at advanced age after cardiac arrest ( CA ) and resuscitation are not well understood. Because protein homeostasis (proteostasis) is essential for cellular and organismal health, but is impaired afte
Autor:
Miwa Izutsu, Rafael E Chaparro, Hideki Taninishi, Larry B. Goldstein, Molly Pearlstein, Huaxin Sheng, David S. Warner
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 36:2203-2210
Scoring systems are used to measure behavioral deficits in stroke research. Video-assisted training is used to standardize stroke-related neurologic deficit scoring in humans. We hypothesized that a video-assisted training and certification program c