Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Gerald J Obermair"'
Autor:
Friederike Stephani, Veronika Scheuer, Tobias Eckrich, Kerstin Blum, Wenying Wang, Gerald J. Obermair, Jutta Engel
Publikováno v:
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Voltage-gated Ca2+ channels are composed of a pore-forming α1 subunit and auxiliary β and α2δ subunits, which modulate Ca2+ current properties and channel trafficking. So far, the partial redundancy and specificity of α1 for α2δ subunits in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52350c83633b6c55e53a87e0ff9d4c7
Stabilization of negative activation voltages of Cav1.3 L-Type Ca2+-channels by alternative splicing
Autor:
Alexandra Pinggera, Jörg Striessnig, Petronel Tuluc, Nadja T. Hofer, Yuliia V. Nikonishyna, Gerald J. Obermair, Eva Maria Fritz
Publikováno v:
Channels
article-version (VoR) Version of Record
article-version (VoR) Version of Record
>Low voltage-activated Cav1.3 L-type Ca2+-channels are key regulators of neuronal excitability controlling neuronal development and different types of learning and memory. Their physiological functions are enabled by their negative activation voltage
Autor:
Stefanie M Geisler, Cornelia Ablinger, Gerald J. Obermair, Ruslan I. Stanika, Christian Klein
Publikováno v:
Pflugers Archiv
α2δ proteins are membrane-anchored extracellular glycoproteins which are abundantly expressed in the brain and the peripheral nervous system. They serve as regulatory subunits of voltage-gated calcium channels and, particularly in nerve cells, regu
Autor:
Miao Sun, Astrid Rohlmann, Anna Ciuraszkiewicz-Wojciech, Renato Frischknecht, Romy Freund, Sara Enrile Lacalle, Markus Missler, Arthur Bikbaev, Jessica Mitlöhner, Valentina Di Biase, Jennifer Heck, Gerald J. Obermair, Oliver Klatt, Daniele Repetto, Martin Heine, Cornelia Ablinger
Publikováno v:
The Journal of Neuroscience
VGCCs are multisubunit complexes that play a crucial role in neuronal signaling. Auxiliary α2δ subunits of VGCCs modulate trafficking and biophysical properties of the pore-forming α1 subunit and trigger excitatory synaptogenesis. Alterations in t
Autor:
Daniele Repetto, Clemens L Schöpf, Markus Missler, Stefanie Geisler, Larissa Traxler, Marcus Kalb, Marta Campiglio, Ruslan Stanika, Gerald J. Obermair
Publikováno v:
The Journal of Neuroscience. 39:2581-2605
Presynaptic α2δ subunits of voltage-gated calcium channels regulate channel abundance and are involved in glutamatergic synapse formation. However, little is known about the specific functions of the individual α2δ isoforms and their role in GABA
Autor:
Georg Dechant, Gerald J. Obermair, Roxana Nat, Carlo Bavassano, Ruslan Stanika, Sylvia Boesch, Andreas Eigentler
Publikováno v:
Stem Cells and Development
Spinocerebellar ataxia type 6 (SCA6) is an autosomal-dominant neurodegenerative disorder that is caused by a CAG trinucleotide repeat expansion in the CACNA1A gene. As one of the few bicistronic genes discovered in the human genome, CACNA1A encodes n
Autor:
Gerald J. Obermair, M Urbanek, K Wegleiter, Ursula Kiechl-Kohlendorfer, Ruslan Stanika, Karina Wechselberger, Elke Griesmaier, Anna Posod, Eva Huber
Publikováno v:
Neuroscience. 352:88-96
Neonatal brain injury is a problem of global importance. To date, no causal therapies are available. A substance with considerable therapeutic potential is the endogenous neuropeptide secretoneurin (SN), which has proven to be beneficial in adult str
Autor:
Erik Renström, Arnold Schwartz, Petronel Tuluc, Jörg Striessnig, Bernhard E. Flucher, Gerald J. Obermair, Mathias Drach, Helene Hofer, Sylvia M. Flucher, Vincenzo Mastrolia
Publikováno v:
Diabetes
Reduced pancreatic β-cell function or mass is the critical problem in developing diabetes. Insulin release from β-cells depends on Ca(2+) influx through high voltage– gated Ca(2+) channels (HVCCs). Ca(2+) influx also regulates insulin synthesis a
Autor:
Emilio Carbone, Chiara Salio, Randall L. Rasmusson, Chiara Riganti, Petronel Tuluc, Glenna C.L. Bett, Marco Sassoè-Pognetto, Chiara Calorio, Gerald J. Obermair, Emilia Turco, Fiorella Balzac, Daniela Gavello, Paola Defilippi, Laura Guarina, Nadja T. Hofer, F. Bianchi
KEY POINTS: Tymothy syndrome (TS) is a multisystem disorder featuring cardiac arrhythmias, autism and adrenal gland dysfunction that originates from a de novo point mutation in the gene encoding the Cav1.2 (CACNA1C) L‐type channel. To study the rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b13a13c4ccb5b54701d4b9fc1748099
http://hdl.handle.net/2318/1694883
http://hdl.handle.net/2318/1694883
Autor:
Junghee Jin, Lucian Medrihan, Zhen Yan, Claire Song, Paul Greengard, Ping Zhong, Cassandra L. Kooiker, Jodi Gresack, Jung Hyuck Ahn, Jia Cheng, Yong Kim, Ko Woon Lee, Gerald J. Obermair, Dionnet L. Bhatti, Amy S. Lee, Jing Wei
Publikováno v:
Molecular psychiatry
Genetic polymorphisms of the L-type voltage-gated calcium channel (VGCC) are associated with psychiatric disorders including major depressive disorder. Alterations of S100A10 (p11) level are also implicated in the etiology of major depressive disorde