Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Eric Fabian"'
Publikováno v:
Archives of Toxicology 95 (2021)
Archives of Toxicology, 95, 91-102
Archives of Toxicology
Archives of Toxicology, 95, 91-102
Archives of Toxicology
The aim of the present study was to develop a generic rat physiologically based kinetic (PBK) model that includes a novel testing strategy where active biliary excretion is incorporated using estradiol-17β glucuronide (E217βG) as the model substanc
Autor:
Peifeng Ren, Felix F. Schmidt, Annika Heckmanns, Mao Wang, Franz Oesch, Anita Samuga, Brandy Riffle, Eric Fabian, Helen Hammer, Robert Landsiedel, Bennard van Ravenzwaay, Oliver Pötz
Publikováno v:
Archives of Toxicology. 94:2663-2682
Xenobiotica-metabolizing enzyme (XME) induction is a relevant biological/biochemical process vital to understanding the toxicological profile of xenobiotics. Early recognition of XME induction potential of compounds under development is therefore imp
Publikováno v:
Toxicology letters. 330
Metiram is a polymeric plant protection fungicidal product. Since farm workers can potentially be exposed to the used solo-formulation, polyram, its dermal penetration is important for the assessment of its safety. Previous dermal penetration studies
Autor:
Eric Fabian, M. Aggarwal, Richard C. Peffer, Kristie Sullivan, Jon R. Heylings, C. Wiemann, Prakashchandra P V Shah, Jonathan M Akins, Hans Raabe
Publikováno v:
Regulatory Toxicology and Pharmacology. 90:197-205
Although an internationally-adopted in vitro dermal absorption test guideline is available (OECD Test Guideline 428), the replacement of the in vivo approach in North America for pesticide formulations has not occurred due to concern over the reliabi
Publikováno v:
Archives of toxicology. 93(12)
The xenobiotic metabolism in the lung, an organ of first entry of xenobiotics into the organism, is crucial for inhaled compounds entering this organ intentionally (e.g. drugs) and unintentionally (e.g. work place and environmental compounds). Additi
Autor:
Hequn Li, Eric Fabian, Xinyi Wang, Bennard van Ravenzwaay, Franziska Engel, Robert Landsiedel
Publikováno v:
Toxicology in Vitro, 33, 174-179
Toxicology in Vitro 33 (2016)
Toxicology in Vitro 33 (2016)
In order to assess whether the placental metabolism of xenobiotic compounds should be taken into consideration for physiologically-based toxicokinetic (PBTK) modelling, the activities of seven phase I and phase II enzymes have been quantified in the
Autor:
Bennard van Ravenzwaay, Barbara Birk, Caroline Gomes, Rene Zbranek, Tabitha Williford, Christian Haase, Tzutzuy Ramirez Hernandez, Robert Landsiedel, Eric Fabian
Publikováno v:
Archives of toxicology. 93(2)
While in vitro testing is used to identify hazards of chemicals, nominal in vitro assay concentrations may misrepresent potential in vivo effects and do not provide dose–response data which can be used for a risk assessment. We used reverse dosimet
Publikováno v:
Archives of Toxicology, 92(3), 1075-1088
Archives of Toxicology 92 (2018) 3
Archives of Toxicology
Archives of Toxicology 92 (2018) 3
Archives of Toxicology
Physiologically based kinetic (PBK) modelling-based reverse dosimetry is a promising tool for the prediction of in vivo developmental toxicity using in vitro concentration–response data. In the present study, the potential of this approach to predi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c83ea63d489ace69d5843d7d8d279c
https://research.wur.nl/en/publications/towards-a-generic-physiologically-based-kinetic-model-to-predict-
https://research.wur.nl/en/publications/towards-a-generic-physiologically-based-kinetic-model-to-predict-
Autor:
Markus Frericks, Andrew Van Cott, Bennard van Ravenzwaay, Eric Fabian, Charles Hastings, Burkhard Flick, Naveed Honarvar
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 95
Afidopyropen is a novel insecticide that acts as a TRPV channel modulator in chordotonal organs of target insects. In two carcinogenicity studies with Fischer rats, an increased incidence of uterine adenocarcinomas was observed at 1000 and 3000 ppm.
Publikováno v:
Archives of Toxicology. 92:3439-3439
This article is published with the incorrect copyright holder name in the HTML article as “© Springer 2018”. The correct copyright line should read “The Author(s) 2018” (as it appears in the article PDF).