Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Daniel, H Geschwind"'
Autor:
Michael I. Love, Justin M. Wolter, Marianna Yusupova, Oleh Krupa, Michael J. Lafferty, Angela L. Elwell, Dan Liang, Kenan P. Courtney, Melanie E. Garrett, Felix A Kyere, Jason L. Stein, Nil Aygün, Daniel H. Geschwind, Luis de la Torre-Ubieta, Kerry E. Cheek, Gregory E. Crawford, Allison E. Ashley-Koch
Publikováno v:
Nature neuroscience
Common genetic risk for neuropsychiatric disorders is enriched in regulatory elements active during cortical neurogenesis. However, it remains poorly understood as to how these variants influence gene regulation. To model the functional impact of com
Autor:
Steve Horvath, Aaron Gordon, Jimena Andersen, John R. Huguenard, Xinshu Xiao, Jin-Young Park, Christopher D. Makinson, Sergiu P. Pașca, Daniel H. Geschwind, Se-Jin Yoon, Stephen Tran, Alfredo M. Valencia
Publikováno v:
Nature neuroscience
Human stem-cell-derived models provide the promise of accelerating our understanding of brain disorders, but not knowing whether they possess the ability to mature beyond mid- to late-fetal stages potentially limits their utility. We leveraged a dire
Autor:
Arthur W. Toga, Virginia E. Sturm, Walter A. Kukull, Leah K. Forsberg, Ging-Yuek Robin Hsiung, Ian R. A. Mackenzie, Howard Feldman, Howard J. Rosen, Neill R. Graff-Radford, Bruce L. Miller, Joel H. Kramer, Artfl, John C Van Swieten, Jersey Deng, Julie A. Fields, Adam L. Boxer, Sandra Weintraub, Bonnie Wong, Erik D. Roberson, Bradford C. Dickerson, Murray Grossman, Eliana Marisa Ramos, Maria I. Lapid, Stephanie A. Chu, Kejal Kantarci, Liwen Zhang, Ashley Vetor, Tatiana Foroud, William W. Seeley, Zbigniew K. Wszolek, John Kornak, Mario F. Mendez, Adam M. Staffaroni, Maria Carmela Tartaglia, Jamie Fong, Chiadi U. Onyike, Hilary W. Heuer, Irene Litvan, Nadine Tatton, Edward D. Huey, Lize C. Jiskoot, Danielle Brushaber, David J Irwin, Suzee E. Lee, Nupur Ghoshal, Janne M. Papma, Yvette Bordelon, Ralitza H. Gavrilova, Anna Karydas, Taru Flagan, David S. Knopman, Kelley Faber, Daniel H. Geschwind, Jennifer S. Yokoyama, Salvatore Spina, Rosa Rademakers, Bradley F. Boeve, Giovanni Coppola, Alexander Pantelyat, Daniel I. Kaufer
Publikováno v:
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology, 8(1), 95-110. John Wiley & Sons Inc.
Annals of Clinical and Translational Neurology, 8(1), 95-110. John Wiley & Sons Inc.
Objective: MAPT mutations typically cause behavioral variant frontotemporal dementia with or without parkinsonism. Previous studies have shown that symptomatic MAPT mutation carriers have frontotemporal atrophy, yet studies have shown mixed results a
Autor:
Xuelian He, Bo Chen, Aboozar Monavarfeshani, Phillip G. Popovich, Anne Jacobi, Riki Kawaguchi, Daniel H. Geschwind, Junjie Zhu, Yu Zhang, Zhiyun Yang, Zhigang He, Yi Li, Songlin Zhou, Vivek Swarup, Q. Wang, Huyan Meng, Zhongju Shi
Publikováno v:
Nature
Spinal cord injury in mammals is thought to trigger scar formation with little regeneration of axons1–4. Here we show that a crush injury to the spinal cord in neonatal mice leads to scar-free healing that permits the growth of long projecting axon
Autor:
Chloe C. Y. Wong, Gokul Ramaswami, Jillian R. Haney, Michael J. Gandal, Jerry C. Wang, Daniel H. Geschwind, Jonathan Mill, Shyam Prabhakar, Wenjie Sun, Hyejung Won
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Autism spectrum disorder (ASD) is a phenotypically and genetically heterogeneous neurodevelopmental disorder. Despite this heterogeneity, previous studies have shown patterns of molecular convergence in post-mortem brain tissue from autistic subjects
Autor:
Thomas E. Mahan, Deepti Lall, David M. Holtzman, Rita Sattler, A.K.M. Ghulam Muhammad, Michael Vazquez, Jesse Landeros, Daniel H. Geschwind, Hayk Davtyan, Ileana Lorenzini, Jacqueline G. O’Rourke, Jason D. Ulrich, Thomas A. Mota, Shaughn Bell, Junwon Kim, Jessica E. Rexach, Layla Ghaffari, Oksana Shelest, Mathew Blurton-Jones, Robert H. Baloh
Publikováno v:
Neuron, vol 109, iss 14
C9orf72 repeat expansions cause inherited amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) and result in both loss of C9orf72 protein expression and production of potentially toxic RNA and dipeptide repeat proteins. In addition to AL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31b1ab4973804c5e9402cb574f064cf
https://escholarship.org/uc/item/9ws7v673
https://escholarship.org/uc/item/9ws7v673
Autor:
Marlesa Godoy, Xia Yang, Jiwen Li, William G Pembroke, Lin Pan, Michael C. Condro, Harley I. Kornblum, Jessica E. Rexach, Steven A. Goldman, Daniel H. Geschwind, Linsey Stiles, Yen-Wei Chen, Angela Y. Chen, Ye Zhang, Mineli Harteni, Ina B. Wanner, Alvaro G. Alvarado
Publikováno v:
Nature communications, vol 12, iss 1
Li, J, Pan, L, Godoy, M, Pembroke, W G, Rexach, J E, Condro, M C, Alvarado, A G, Harteni, M, Chen, Y-W, Stiles, L, Chen, A Y, Wanner, I B, Yang, X, Goldman, S A, Geschwind, D H, Kornblum, H & Zhang, Y 2021, ' Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes ', Nature Communications, vol. 12, no. 1, 3958 . https://doi.org/10.1038/s41467-021-24232-3
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Li, J, Pan, L, Godoy, M, Pembroke, W G, Rexach, J E, Condro, M C, Alvarado, A G, Harteni, M, Chen, Y-W, Stiles, L, Chen, A Y, Wanner, I B, Yang, X, Goldman, S A, Geschwind, D H, Kornblum, H & Zhang, Y 2021, ' Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes ', Nature Communications, vol. 12, no. 1, 3958 . https://doi.org/10.1038/s41467-021-24232-3
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Astrocytes play important roles in neurological disorders such as stroke, injury, and neurodegeneration. Most knowledge on astrocyte biology is based on studies of mouse models and the similarities and differences between human and mouse astrocytes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fdf29ea59d3d4b1e05472ac4de6a42
https://escholarship.org/uc/item/2290r3jj
https://escholarship.org/uc/item/2290r3jj
Autor:
Daniel H. Geschwind, Jessica E. Rexach
Publikováno v:
Neuron
A major obstacle to treating Alzheimer’s disease (AD) is our lack of understanding of the molecular mechanisms underlying selective neuronal vulnerability, which is a key characteristic of the disease. Here we present a framework integrating high-q
Autor:
Timothy S. Chang, Yi Ding, Malika K. Freund, Ruth Johnson, Tommer Schwarz, Julie M. Yabu, Chad Hazlett, Jeffrey N. Chiang, David A. Wulf, Daniel H. Geschwind, Manish J. Butte, Bogdan Pasaniuc, Anna L. Antonio, Maryam Ariannejad, Angela M. Badillo, Brunilda Balliu, Yael Berkovich, Michael Broudy, Tony Dang, Chris Denny, Eleazar Eskin, Eran Halperin, Brian L. Hill, Ankur Jain, Vivek Katakwar, Clara Lajonchere, Clara Magyar, Sheila Minton, Ghouse Mohammed, Ariff Muhamed, Pabba Pavan, Michael A. Pfeffer, Nadav Rakocz, Akos Rudas, Rey Salonga, Timothy J. Sanders, Paul Tung, Vu Vu, Ailsa Zheng
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102188-(2021)
iScience
iScience
Coronavirus disease 2019 (COVID-19) has exposed health care disparities in minority groups including Hispanics/Latinxs (HL). Studies of COVID-19 risk factors for HL have relied on county-level data. We investigated COVID-19 risk factors in HL using i
Autor:
Maria Andreina Mendez, Roland Nagy, David Skuse, Eva P. Valencia-Alarcón, Jamie Horder, Irene Lee, Frances Flinter, Grainne M. McAlonan, Simon Baron-Cohen, Declan G. Murphy, Kamila M. Jozwik, Jason S. Carroll, Daniel H. Geschwind, Lucia Dutan, Paulina Nowosiad, Dwaipayan Adhya, Jack Price, Vivek Swarup, Carole Shum, Eva Loth, Deepak Srivastava
Publikováno v:
Adhya, D, Swarup, V, Nagy, R, Dutan Polit, L, Shum, C, Valencia-Alarcón, E, Jozwik, K, Mendez Hernandez, M, Horder, J, Loth, E, Nowosiad, P, Lee, I, Skuse, D, Flinter, F, Murphy, D, McAlonan, G, Geschwind, D H, Price, J, Carroll, J, Srivastava, D & Baron-Cohen, S 2020, ' Atypical neurogenesis in induced pluripotent stem cell (iPSC) from autistic individuals ', Biological psychiatry . https://doi.org/10.1016/j.biopsych.2020.06.014
Biological Psychiatry
Biological Psychiatry
BackgroundAutism is a heterogenous collection of disorders with a complex molecular underpinning. Evidence from post-mortem brain studies using adult brains have indicated that early prenatal development may be altered in autism. Induced pluripotent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d1d7df9dd39a663e7d9cfbddb68f6b
https://www.repository.cam.ac.uk/handle/1810/307568
https://www.repository.cam.ac.uk/handle/1810/307568