Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Christopher J. Schofield"'
Autor:
James Wickens, Adam P. Hardy, Anthony Tumber, Martine I. Abboud, Michael A. McDonough, Christopher T. Lohans, Rasheduzzaman Chowdhury, Christopher M. West, Kerstin Lippl, Christopher J. Schofield, Elisabete Pires, Tongri Liu
Publikováno v:
The Journal of Biological Chemistry
In animals, the response to chronic hypoxia is mediated by prolyl hydroxylases (PHDs) that regulate the levels of hypoxia-inducible transcription factor α (HIFα). PHD homologues exist in other types of eukaryotes and prokaryotes where they act on n
Autor:
Rok Sekirnik, Kuo-Feng Hsu, Akane Kawamura, James S. O. McCullagh, Richard J. Hopkinson, Emily Flashman, Sarah E. Wilkins, Christopher J. Schofield, Louise J. Walport
Publikováno v:
Epigenetics
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Post-translational modifications (PTMs) to the tails of the core histone proteins are critically involved in epigenetic regulation. Hypoxia affects histone modifications by altering the activities of histone-modifying enzymes and the levels of hypoxi
Autor:
Anders Moen, Jesper V. Olsen, Lisa Schroer, Ida A. Grønsberg, Niels Eijkelkamp, Albert Jeltsch, Takehiro Suzuki, Tadahiro Shimazu, Naoshi Dohmae, Erna Davydova, Mikiko Sodeoka, Valentina Siino, Mai Akakabe, Jędrzej Małecki, Pål Ø. Falnes, Michael A. McDonough, Takashi Umehara, Yoshihiro Sohtome, Magnus E. Jakobsson, Angela Ho, Rita Pinto, Masaki Kikuchi, Sara Weirich, Christopher J. Schofield, Yoichi Shinkai, Hanneke L.D.M. Willemen, Maren Kirstin Schuhmacher, Tongri Liu
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Davydova, E, Shimazu, T, Schuhmacher, M K, Jakobsson, M E, Willemen, H L D M, Liu, T, Moen, A, Ho, A Y Y, Małecki, J, Schroer, L, Pinto, R, Suzuki, T, Grønsberg, I A, Sohtome, Y, Akakabe, M, Weirich, S, Kikuchi, M, Olsen, J V, Dohmae, N, Umehara, T, Sodeoka, M, Siino, V, McDonough, M A, Eijkelkamp, N, Schofield, C J, Jeltsch, A, Shinkai, Y & Falnes, P 2021, ' The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes ', Nature Communications, vol. 12, 891 . https://doi.org/10.1038/s41467-020-20670-7
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Davydova, E, Shimazu, T, Schuhmacher, M K, Jakobsson, M E, Willemen, H L D M, Liu, T, Moen, A, Ho, A Y Y, Małecki, J, Schroer, L, Pinto, R, Suzuki, T, Grønsberg, I A, Sohtome, Y, Akakabe, M, Weirich, S, Kikuchi, M, Olsen, J V, Dohmae, N, Umehara, T, Sodeoka, M, Siino, V, McDonough, M A, Eijkelkamp, N, Schofield, C J, Jeltsch, A, Shinkai, Y & Falnes, P 2021, ' The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes ', Nature Communications, vol. 12, 891 . https://doi.org/10.1038/s41467-020-20670-7
Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers 1- and 3-methylhistidine (1MH and 3MH), was first reported five decades ago, but remains la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8df554296bacb78fc88ad2f9d35057
https://ora.ox.ac.uk/objects/uuid:5d2edc4d-b490-4789-a8f9-e3a23c7392d4
https://ora.ox.ac.uk/objects/uuid:5d2edc4d-b490-4789-a8f9-e3a23c7392d4
Autor:
M.A. Redhead, Patrick Collins, Tika R. Malla, Claire Strain-Damerell, Sean W. Robinson, Jan Thibaut, David I. Stuart, Anthony Tumber, Mark Swindells, C. David Owen, Philipp Schäfer, Chris J Radoux, Laura Vangeel, Frank von Delft, A.L. Hopkins, Mitchell V. Hull, Pieter Leyssen, Thomas Vercruysse, David J. Hallett, D. Fearon, Tu Trinh Nguyen, Martin A. Walsh, Alice Douangamath, Iva Navratilova Hopkins, Amelia H. Collette, Christopher J. Schofield, Lennart Brewitz, Petra Lukacik
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Effective agents to treat coronavirus infection are urgently required, not only to treat COVID-19, but to prepare for future outbreaks. Repurposed anti-virals such as remdesivir and human anti-inflammatories such as barcitinib have received emergency
Autor:
Takuma Uo, Maryou B. Lambros, Suzanne Carreira, Ruth Riisnaes, Veronica Gil, Juan M. Jiménez-Vacas, Ana Ferreira, Susana Miranda, Andrea Alimonti, Jonathan Welti, Lorenzo Buroni, Mateus Crespo, Anthony Tumber, Daniel Nava Rodrigues, Marc A. Moesser, Alec Paschalis, Antje Neeb, Martine I. Abboud, Nina Tunariu, Patrizio Di Micco, Md. Saiful Islam, Akane Kawamura, Rossitza Christova, Wei Yuan, Bissan Al-Lazikani, Ines Figueiredo, Rita Pereira, Christopher J. Schofield, Stephen R. Plymate, Johann S. de Bono, Bora Gurel, Adam Sharp, Soojin Kim
Publikováno v:
Cancer Res
Endocrine resistance (EnR) in advanced prostate cancer is fatal. EnR can be mediated by androgen receptor (AR) splice variants, with AR splice variant 7 (AR-V7) arguably the most clinically important variant. In this study, we determined proteins key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbb4101eee9ccbabd94af29f3d9f9e6
http://hdl.handle.net/11577/3381996
http://hdl.handle.net/11577/3381996
Autor:
Patrick Rabe, Christopher J. Schofield, Yuri Ermolovich, Tharindi D. Panduwawala, Jürgen Brem, Karina Calvopiña, Alistair J. M. Farley, Fredrik Björkling
Publikováno v:
Farley, A J M, Ermolovich, Y, Calvopiña, K, Rabe, P, Panduwawala, T, Brem, J, Björkling, F & Schofield, C J 2021, ' Structural Basis of Metallo-β-lactamase Inhibition by N-Sulfamoylpyrrole-2-carboxylates ', ACS Infectious Diseases, vol. 7, no. 6, pp. 1809–1817 . https://doi.org/10.1021/acsinfecdis.1c00104
ACS Infectious Diseases
ACS Infectious Diseases
Metallo-β-lactamases (MBLs) can efficiently catalyze the hydrolysis of all classes of β-lactam antibiotics except monobactams. While serine-β-lactamase (SBL) inhibitors (e.g., clavulanic acid, avibactam) are established for clinical use, no such M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d418daa9999253390b86c6519304f6
https://curis.ku.dk/ws/files/285447738/acsinfecdis.1c00104.pdf
https://curis.ku.dk/ws/files/285447738/acsinfecdis.1c00104.pdf
Autor:
Jozef Durko, Andrea Tavosanis, Peter Giles, Hannah Lawson, Alena Shmakova, Nicholas M. Morton, Douglas Vernimmen, Dónal O'Carroll, Marie O'Shea, Neil P. Rodrigues, Amelie V. Guitart, Melania Barile, Andreas Lengeling, Kamil R. Kranc, Roderick N. Carter, Berthold Göttgens, Elise Georges, Milica Vukovic, Lewis Allen, Penny Timms, Catarina Sepulveda, Christopher J. Schofield, Joana Campos, Louie N. van de Lagemaat
Publikováno v:
Blood Adv
Lawson, H, Sepulveda, C, van de Lagemaat, L N, Durko, J, Barile, M, Tavosanis, A, Georges, E, Shmakova, A, Timms, P, Carter, R N, Allen, L, Campos, J, Vukovic, M, Guitart, A V, Giles, P, O'Shea, M, Vernimmen, D, Morton, N M, Rodrigues, N P, Göttgens, B, Schofield, C J, Lengeling, A, O'Carroll, D & Kranc, K R 2021, ' JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells ', Blood Advances, vol. 5, no. 3, pp. 889-899 . https://doi.org/10.1182/bloodadvances.2020002702
Lawson, H, Sepulveda, C, van de Lagemaat, L N, Durko, J, Barile, M, Tavosanis, A, Georges, E, Shmakova, A, Timms, P, Carter, R N, Allen, L, Campos, J, Vukovic, M, Guitart, A V, Giles, P, O'Shea, M, Vernimmen, D, Morton, N M, Rodrigues, N P, Göttgens, B, Schofield, C J, Lengeling, A, O'Carroll, D & Kranc, K R 2021, ' JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells ', Blood Advances, vol. 5, no. 3, pp. 889-899 . https://doi.org/10.1182/bloodadvances.2020002702
Lifelong multilineage hematopoiesis critically depends on rare hematopoietic stem cells (HSCs) that reside in the hypoxic bone marrow microenvironment. Although the role of the canonical oxygen sensor hypoxia-inducible factor prolyl hydroxylase has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9ce5b949122a2f262c58d0ad509090
Autor:
Christopher J. Schofield, Paolo Spingardi, Tobias John, Akane Kawamura, Richard J. Hopkinson, Raphael Reinbold
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-5 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-5 (2020)
Metampicillin is a β-lactam antibiotic that is prepared by the reaction of ampicillin with formaldehyde. Although metampicillin has been studied for treatment of infections in animals and humans, its structure has been unclear. We report NMR studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13864a1e9b1dda101e8dc2b737e03f7c
https://ora.ox.ac.uk/objects/uuid:8bd79c2b-d47f-42aa-8c4e-95099aabf873
https://ora.ox.ac.uk/objects/uuid:8bd79c2b-d47f-42aa-8c4e-95099aabf873
Publikováno v:
The Journal of Biological Chemistry
An important mechanism of resistance to β-lactam antibiotics is via their β-lactamase–catalyzed hydrolysis. Recent work has shown that, in addition to the established hydrolysis products, the reaction of the class D nucleophilic serine β-lactama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c78d2928662005747931daead404bb
https://ora.ox.ac.uk/objects/uuid:6d399037-b26f-4793-8239-2aa7361e7f2b
https://ora.ox.ac.uk/objects/uuid:6d399037-b26f-4793-8239-2aa7361e7f2b
Publikováno v:
Current Opinion in Chemical Biology
Abnormal metabolism is common in cancer cells and often correlates with mutations in genes encoding for enzymes involved in small-molecule metabolism. Isocitrate dehydrogenase 1 (IDH1) is the most frequently mutated metabolic gene in cancer. Cancer-a