Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Christian Sell"'
Publikováno v:
Cell Cycle
A key to longevity assurance is the nutrient-sensing mTOR pathway. Inhibition of mTOR extends lifespan in a variety of organisms. However, the downstream effectors of the mTOR pathway for lifespan regulation are elusive. In a recent report, we descri
Autor:
Christina Lee Chung, Ibiyonu Lawrence, Melissa Hoffman, Manali Potnis, Christian Sell, Kumar S. Nadhan, Catlin Sershon, Dareen Elgindi, Annie Jin, Antonello Lorenzini, Rhonda Binnebose
Publikováno v:
GeroScience
Aging is a major risk factor for the majority of human diseases, and the development of interventions to reduce the intrinsic rate of aging is expected to reduce the risk for age-related diseases including cardiovascular disease, cancer, and dementia
Autor:
Carlos S. Reyna-Blanco, Vanessa Carina Bieker, Detlef Jantzen, Christoph Leuenberger, Joachim Burger, Yoan Diekmann, Daniel Wegmann, Anna Schulz, Laura Winkelbach, Elke Kaiser, Jens Blöcher, Gundula Lidke, Jörg Orschiedt, Thomas Terberger, Zoé Pochon, Thomas S. Bertino, Mark G. Thomas, Amelie Scheu, Ute Brinker, Krishna R. Veeramah, Christian Sell, Vivian Link, Ruth Bollongino, Sofija Stefanović, Aleksandra Žegarac, Zuzana Hofmanová
Publikováno v:
Current Biology
Lactase persistence (LP), the continued expression of lactase into adulthood, is the most strongly selected single gene trait over the last 10,000 years inmultiple human populations. It has been posited that the primary allele causing LP among Eurasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f04d11782b17fc47dde194c839150e3
https://zenodo.org/record/5751837
https://zenodo.org/record/5751837
Autor:
Eishi Noguchi, Joshua Chang Mell, Sydney Wilson, Esteban Martínez, Christian Sell, Mihir Shetty, Kazuhiro Shiozaki, Chiaki Noguchi
Publikováno v:
Aging cell, vol 19, iss 2
Aging Cell
Aging Cell
Maf1 is the master repressor of RNA polymerase III responsible for transcription of tRNAs and 5S rRNAs. Maf1 is negatively regulated via phosphorylation by the mTOR pathway, which governs protein synthesis, growth control, and lifespan regulation in
Publikováno v:
GeroScience. 40:243-256
Inhibition of mTOR signaling using rapamycin has been shown to increase lifespan and healthspan in multiple model organisms; however, the precise mechanisms for the beneficial effects of rapamycin remain uncertain. We have previously reported that ra
Autor:
Claudio Torres, Michael Bene, Christian Sell, Ashley Azar, Timothy Nacarelli, Gregg J. Johannes, Ibiyonu Lawrence, Justin Cohen
Publikováno v:
GeroScience. 40:193-199
Cellular senescence is a central component of the aging process. This cellular response has been found to be induced by multiple forms of molecular damage and senescent cells increase in number with age in all tissues examined to date. We have examin
Autor:
Lucy van Dorp, Garrett Hellenthal, Joachim Burger, Zuzana Hofmanová, Krishna R. Veeramah, Jens Blöcher, Christian Sell, Vivian Link, Bernd Päffgen, Brigitte Haas-Gebhard, Bernd Trautmann, Anja Gairhos, Jochen Haberstroh, Michaela Harbeck, Daniel Wegmann, Joris Peters, Saioa López, Andreas Rott, Melanie Groß, Karola Kirsanow
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Many modern European states trace their roots back to a period known as the Migration Period that spans from Late Antiquity to the early Middle Ages. We have conducted the first population-level analysis of people from this era, generati
Publikováno v:
Annals of the New York Academy of Sciences. 1418:95-105
Both methionine restriction and rapamycin treatment are robust longevity-enhancing regimens for which the mechanisms remain unclear. Cellular senescence is a major contributor to the aging process, and we find that both the methionine and rapamycin r
Autor:
Christian Sell, Timothy Nacarelli
Publikováno v:
Molecular and Cellular Endocrinology. 455:83-92
Cellular senescence has gained much attention as a contributor to aging and susceptibility to disease. Senescent cells undergo a stable cell cycle arrest and produce pro-inflammatory cytokines. However, an additional feature of the senescence phenoty
Autor:
Gianluca Storci, Silvia Marchionni, Claudio Franceschi, Eleonora Croco, Thomas D. Stamato, Massimiliano Bonafè, Antonello Lorenzini, Christian Sell
Publikováno v:
Biogerontology
In evolutionary terms, life on the planet has taken the form of independently living cells for the majority of time. In comparison, the mammalian radiation is a relatively recent event. The common mammalian ancestor was probably small and short-lived