Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Catherine L. Drennan"'
Publikováno v:
Science
Caught in the act Proton-coupled electron transfer (PCET) is an important process for moving electrons through proteins and requires precise positioning of suitable proton and electron carriers. Kang et al. determined a cryo–electron microscopy str
Autor:
Mériem Merrouch, Catherine L. Drennan, Vincent Fourmond, Elizabeth C. Wittenborn, Steven E. Cohen, Sébastien Dementin, Christophe Léger
Publikováno v:
J Biol Chem
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, In press, pp.jbc.RA119.009610. ⟨10.1074/jbc.RA119.009610⟩
Journal of Biological Chemistry, In press, pp.jbc.RA119.009610. ⟨10.1074/jbc.RA119.009610⟩
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, In press, pp.jbc.RA119.009610. ⟨10.1074/jbc.RA119.009610⟩
Journal of Biological Chemistry, In press, pp.jbc.RA119.009610. ⟨10.1074/jbc.RA119.009610⟩
The nickel-dependent carbon monoxide dehydrogenase (CODH) employs a unique heterometallic nickel–iron–sulfur cluster, termed the C-cluster, to catalyze the interconversion of CO and CO(2). Like other complex metalloenzymes, CODH requires dedicate
Autor:
William M. Kincannon, Nathan A. Bruender, Elizabeth J. Blaesi, Vahe Bandarian, Catherine L. Drennan, Tsehai A.J. Grell, Carsten Krebs
Publikováno v:
The Journal of Biological Chemistry
Sactipeptides are a subclass of ribosomally synthesized and post-translationally modified peptides (RiPPs). They contain a unique thioether bond, referred to as a sactionine linkage, between the sulfur atom of a cysteine residue and the α-carbon of
Autor:
Maanasa Narayanamoorthy, Chaoxiang Ren, Antonio Del Rio Flores, Jan Paulo T. Zaragoza, Wenjun Zhang, Heather J. Kulik, Wenlong Cai, Rimsha Mehmood, Rohan Jonnalagadda, Catherine L. Drennan
Publikováno v:
The Journal of Biological Chemistry
Elsevier
Elsevier
The isonitrile moiety is found in marine sponges and some microbes, where it plays a role in processes such as virulence and metal acquisition. Until recently only one route was known for isonitrile biosynthesis, a condensation reaction that brings t
Autor:
Emily P. Balskus, Ronald T. Raines, Mary C. Andorfer, Catherine L. Drennan, Lindsey R. F. Backman, Yolanda Y. Huang, Brian Gold
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
The glycyl radical enzyme (GRE) superfamily utilizes a glycyl radical cofactor to catalyze difficult chemical reactions in a variety of anaerobic microbial metabolic pathways. Recently, a GRE, trans-4-hydroxy-L-proline (Hyp) dehydratase (HypD), was d
Autor:
Nicholas C. Harris, David A. Born, Wenlong Cai, Yaobing Huang, Joelle Martin, Ryan Khalaf, Catherine L. Drennan, Wenjun Zhang
Publikováno v:
Angewandte Chemie. 130:9855-9858
Autor:
Emily M. Zygiel, Elizabeth M. Nolan, Catherine L. Drennan, Toshiki G. Nakashige, Sarah E. J. Bowman
Publikováno v:
Biochemistry. 57:4155-4164
Calprotectin (CP, S100A8/S100A9 oligomer, MRP-8/MRP-14 oligomer) is a host-defense protein that sequesters nutrient transition metals from microbes. Each S100A8/S100A9 heterodimer contains four EF-hand domains and two transition-metal-binding sites.
Publikováno v:
Journal of Biological Chemistry. 293:10404-10412
Ribonucleotide reductases (RNRs) convert ribonucleotides to deoxynucleotides, a process essential for DNA biosynthesis and repair. Class Ia RNRs require two dimeric subunits for activity: an α2 subunit that houses the active site and allosteric regu
Publikováno v:
Journal of the American Chemical Society
TYW1 is a radical S-adenosyl-l-methionine (SAM) enzyme that catalyzes the condensation of pyruvate and N-methylguanosine to form the posttranscriptional modification, 4-demethylwyosine, in situ on transfer RNA (tRNA). Two mechanisms have been propose
Publikováno v:
Proceedings of the National Academy of Sciences. 115:3846-3851
Pyruvate:ferredoxin oxidoreductase (PFOR) is a microbial enzyme that uses thiamine pyrophosphate (TPP), three [4Fe-4S] clusters, and coenzyme A (CoA) in the reversible oxidation of pyruvate to generate acetyl-CoA and carbon dioxide. The two electrons