Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Ayako Suzuki"'
Autor:
M. Isabel Lucena, Kristin Ashby, Minjun Chen, Ismael Alvarez-Alvarez, A. González-Jiménez, Raúl J. Andrade, Ayako Suzuki
Publikováno v:
Archives of Toxicology. 95:1793-1803
Drug-induced liver injury (DILI) presentation varies biochemically and histologically. Certain drugs present quite consistent injury patterns, i.e., DILI signatures. In contrast, others are manifested as broader types of liver injury. The variety of
Autor:
Masashi Ueno, Takuya Okamoto, Yasuko Natsume, Yutaka Suzuki, Yukie Kashima, Mayuko Fukuda, Tetsuo Noda, Hitomi Yamanaka, Yoshiharu Sakai, Satoshi Nagayama, Mayuko Yamamoto, Koji Tsuda, Katsuyuki Yaginuma, Yu Takahashi, Upasna Srivastava, Daisuke Kusama, Ryoji Yao, David duVerle, Fanny Perraudeau, Ayako Suzuki, Yuuta Kuze
Publikováno v:
Stem Cell Reports
Summary Metastasis is the major cause of cancer-related death, but whether metastatic lesions exhibit the same cellular composition as primary tumors has yet to be elucidated. To investigate the cellular heterogeneity of metastatic colorectal cancer
Autor:
Kenji Izumi, Kazuma Kishimoto, Kenta Haga, Emi Hoshikawa, Jun Mizuno, Ayako Suzuki, Taisuke Sato, Keito Miwa, Yoshihiro Kodama
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
The junction between the epithelium and the underlying connective tissue undulates, constituting of rete ridges, which lack currently available soft tissue constructs. In this study, using a micro electro mechanical systems process and soft lithograp
Autor:
Jun Zhang, Roger J. Davis, Meng Li, Christopher Q. Chen, Anna Mae Diehl, Mariam Aghajan, Ying Wang, Robert Win Maw Min, Tin Aung Than, Sanda Win, Neil Kaplowitz, Yibu Chen, Manal F. Abdelmalek, Filbert W.M. Aung, Ayako Suzuki
Publikováno v:
Journal of Clinical Investigation. 129:5278-5293
SH3 domain–binding protein that preferentially associates with Btk (SAB) is an outer-membrane docking protein for JNK-mediated impairment of mitochondrial function. Deletion of Sab in hepatocytes inhibits sustained JNK activation and cell death. Th
Autor:
De Lisa Fairweather, Sanda Win, Stefano Ballestri, Tin Aung Than, Amedeo Lonardo, Fabio Nascimbeni, Ayako Suzuki, Manal F. Abdelmalek
Publikováno v:
Hepatology
Despite tremendous research advancements in nonalcoholic fatty liver disease (NAFLD), our understanding of sex differences in NAFLD remains insufficient. This review summarizes the current knowledge on sex differences in NAFLD, identifies gaps, and d
Publikováno v:
Journal of Human Genetics
Cancer is a disease largely caused by genomic aberrations. Utilizing many rapidly emerging sequencing technologies, researchers have studied cancer genomes to understand the molecular statuses of cancer cells and to reveal their vulnerabilities, such
Autor:
M. Isabel Lucena, Ayako Suzuki, Guruprasad P. Aithal, Wei Zhuang, Ismael Alvarez-Alvarez, Raúl J. Andrade, Minjun Chen, Kristin Ashby, A. González-Jiménez
Background & Aims Although most drug-induced liver injury (DILI) cases resolve after the offending medication is discontinued, time to recovery varies among patients, with 6 –12% developing a chronic disease. Herein, we investigated clinical factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3578991979abe73ea57f1ec078598bd
https://hdl.handle.net/10668/17566
https://hdl.handle.net/10668/17566
Autor:
Emi Hoshikawa, Kenji Izumi, Kenta Haga, Ryota Kobayashi, Taisuke Sato, Ayako Suzuki, Koichi Tabeta
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Cells/colony motion determined by non-invasive, quantitative measurements using the optical flow (OF) algorithm can indicate the oral keratinocyte proliferative capacity in early-phase primary cultures. This study aimed to determine a threshold for t
Autor:
Tatsuya Onishi, Masahide Seki, Tomohiko Ohta, Motohiro Chosokabe, Katsuya Tsuchihara, Tsuguo Iwatani, Takamichi Yokoe, Koichiro Tsugawa, Junki Koike, Manabu Kubota, Ai Motoyoshi, Yutaka Suzuki, Ichiro Maeda, Yuta Kuze, Hibiki Seino, Eisuke Inoue, Yasuyuki Kojima, Satoi Nagasawa, Ayako Suzuki
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
In a substantial number of patients, ductal carcinoma in situ (DCIS) of the breast will never progress to invasive ductal carcinoma, and these patients are often overtreated under the current clinical criteria. Although various candidate markers are
Autor:
Keiichi Onodera, Junko Zenkoh, Hitomi Okazaki, Shoko Nakasone, Genichiro Ishii, Ayako Suzuki, Yutaka Suzuki, Masahiro Tsuboi, Katsuya Tsuchihara
Publikováno v:
Lung cancer (Amsterdam, Netherlands). 158
Objectives Microtubule inhibitors (MTIs) are widely used as anti-cancer drugs for various types of tumors. Vinorelbine, an MTI, is utilized in postoperative adjuvant chemotherapy, especially for lung adenocarcinoma. However, no molecular markers are