Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Amy R Bentley"'
Autor:
Ayo P. Doumatey, Guanjie Chen, Charles N. Rotimi, Kenneth Ekoru, Daniel Shriner, Adebowale Adeyemo, Amy R. Bentley, Jie Zhou
Publikováno v:
Int J Epidemiol
Background There is growing support for the use of genetic risk scores (GRS) in routine clinical settings. Due to the limited diversity of current genomic discovery samples, there are concerns that the predictive power of GRS will be limited in non-E
Publikováno v:
npj Genomic Medicine, Vol 5, Iss 1, Pp 1-9 (2020)
NPJ Genomic Medicine
NPJ Genomic Medicine
The lack of representation of diverse ancestral backgrounds in genomic research is well-known, and the resultant scientific and ethical limitations are becoming increasingly appreciated. The paucity of data on individuals with African ancestry is esp
Autor:
Reem Kais Jan, Daniel L. Kastner, Francesco Boin, Chris T. Derk, Kathleen D. Kolstad, Vivien Hsu, Heather Gladue, Virginia D. Steen, Avram Goldberg, Paula S. Ramos, Victoria K. Shanmugam, Dinesh Khanna, Lorinda Chung, Ayo P. Doumatey, Richard M. Silver, Elana J. Bernstein, Amy R. Bentley, Pravitt Gourh, Nadia D. Morgan, Ami A. Shah, Maureen D. Mayes, Lesley Ann Saketkoo, Fredrick M. Wigley, Steven E. Boyden, Brynn Kron, Elena Schiopu, Benjamin D. Korman, Lindsey A. Criswell, Peter J. Steinbach, S. Louis Bridges, Suzanne Kafaja, Thomas A. Medsger, Daniel Shriner, James C. Mullikin, Settara C. Chandrasekharappa, Jessica K. Gordon, Robyn T. Domsic, Elaine F. Remmers, John Varga, Adebowale Adeyemo, Sarah A. Safran, Theresa Alexander, Marcin Trojanowski, Charles N. Rotimi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 1
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 1
Significance HLA alleles have previously been implicated with scleroderma risk, but, in this study, using a European American ancestral cohort and a newly recruited large cohort of African Americans, we comprehensively define the HLA alleles and amin
Autor:
Sina A. Gharib, Kenneth Rice, Donna K. Arnett, Tõnu Esko, Annemarie I. Luik, Niki Dimou, Dabeeru C. Rao, Pamela J. Schreiner, Melissa A. Richard, Reedik Mägi, Nicholette D. Palmer, Stefan Weiss, Han Chen, Solomon K. Musani, W. James Gauderman, Christian Gieger, Kari E. North, Salman M. Tajuddin, Diana van Heemst, Rainer Rauramaa, Stephen B. Kritchevsky, Henry Völzke, Minjung Kho, Michele K. Evans, Ruth J. F. Loos, Correa Adolfo, Pedro Marques-Vidal, Diane M. Becker, Claude Bouchard, José Haba-Rubio, Georg Homuth, Kurt Lohman, Nora Franceschini, Caizheng Yu, Peter Vollenweider, Ervin F. Fox, Thomas Meitinger, Karen Schwander, Heming Wang, Morris A. Swertz, Aldi T. Kraja, José Eduardo Krieger, Xiuqing Guo, Tangchun Wu, Raymond Noordam, Yongmei Liu, Michael R. Brown, Patrick C.N. Rensen, Annette Peters, Jingmin Liu, Tuomo Rankinen, Robert B. Wallance, Timo A. Lakka, Stephen S. Rich, Yun Ju Sung, Meian He, Till Roenneberg, Wanqing Wen, Dennis O. Mook-Kanamori, M. A. Province, Evangelos Evangelou, L. Adrienne Cupples, Maxime M Bos, Paul S. de Vries, Hans J. Grabe, Lisa R. Yanek, Jiwon Lee, Mario Sims, Bruce M. Psaty, Treva Rice, Tanika N. Kelly, Brenda W.J.H. Penninx, Brigitte Kühnel, Maria E. Graff, Alexandre C. Pereira, Daniel J. Gottlieb, Charles N. Rotimi, Lynne E. Wagenknecht, Ashley van der Spek, Lisa W. Martin, Jeffrey R. O'Connell, Changwei Li, James E. Hixson, Chuan Gao, Alisa K. Manning, Sharon L.R. Kardia, Stella Aslibekyan, Andres Metspalu, Sami Heikkinen, Maris Alver, Xiao-Ou Shu, Amy R. Bentley, Susan Redline, Konstantin Strauch, Tamara B. Harris, Yuri Milaneschi, L.F. Bielak, Marjan Ilkov, Myriam Fornage, Ilja M. Nolte, André G. Uitterlinden, Dina Vojinovic, Hugues Aschard, Paul Elliott, Kent D. Taylor, Najaf Amin, James M. Shikany, Yong-Bing Xiang, Jerome I. Rotter, Vilmundur Gudnason, Cornelia M. van Duijn, Ko Willems van Dijk, Andrea R. V. R. Horimoto, Jonathan Marten, Olli T. Raitakari, Vincent Laville, Pirjo Komulainen, Zhe Wang, Traci M. Bartz, Mary F. Feitosa, Mike A. Nalls, Eric Boerwinkle, Alanna C. Morrison, Melanie Waldenberger, Alexander P. Reiner, Christie M. Ballantyne, Wei Zheng, Raphael Heinzer, M. Arfan Ikram, Colleen M. Sitlani, Lisa de las Fuentes, Patricia B. Munroe, Patricia A. Peyser, Brian E. Cade, Tamar Sofer, Xiaofeng Zhu, Nienke R. Biermasz, Harold Snieder, Elise Lim, Tuomas O. Kilpeläinen, Ching-Ti Liu, Terho Lehtimäki, Thomas W. Winkler, Leo-Pekka Lyytikäinen, Gudny Eiriksdottir, Stephen Sidney, Alan B. Zonderman, Charles Kooperberg
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications, 2019, 10 (1), pp.5121. ⟨10.1038/s41467-019-12958-0⟩
Nature Communications, 10. NATURE PUBLISHING GROUP
Nature Communications, 10:5121. Nature Publishing Group
Nature Communications, 10(1):5121. Nature Publishing Group
Nature Communications, 10(1):5121. Nature Publishing Group UK
Noordam, R, Bos, M M, Wang, H, Winkler, T W, Bentley, A R, Kilpeläinen, T O, de Vries, P S, Sung, Y J, Schwander, K, Cade, B E, Manning, A, Aschard, H, Brown, M R, Chen, H, Franceschini, N, Musani, S K, Richard, M, Vojinovic, D, Aslibekyan, S, Bartz, T M, de las Fuentes, L, Feitosa, M, Horimoto, A R, Ilkov, M, Kho, M, Kraja, A, Li, C, Lim, E, Liu, Y, Mook-Kanamori, D O, Rankinen, T, Tajuddin, S M, van der Spek, A, Wang, Z, Marten, J, Laville, V, Alver, M, Evangelou, E, Graff, M E, He, M, Kühnel, B, Lyytikäinen, L P, Marques-Vidal, P, Nolte, I M, Palmer, N D, Rauramaa, R, Shu, X O, Snieder, H, Weiss, S & Penninx, B W J H 2019, ' Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration ', Nature Communications, vol. 10, no. 1, 5121 . https://doi.org/10.1038/s41467-019-12958-0
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.5121. ⟨10.1038/s41467-019-12958-0⟩
Noordam, R, Bos, M M, Wang, H, Winkler, T W, Bentley, A R, Kilpeläinen, T O, de Vries, P S, Sung, Y J, Schwander, K, Cade, B E, Manning, A, Aschard, H, Brown, M R, Chen, H, Franceschini, N, Musani, S K, Richard, M, Vojinovic, D, Aslibekyan, S, Bartz, T M, de Las Fuentes, L, Feitosa, M, Horimoto, A R, Ilkov, M, Kho, M, Kraja, A, Li, C, Lim, E, Liu, Y, Mook-Kanamori, D O, Rankinen, T, Tajuddin, S M, van der Spek, A, Wang, Z, Marten, J, Laville, V, Alver, M, Evangelou, E, Graff, M E, He, M, Kühnel, B, Lyytikäinen, L-P, Marques-Vidal, P, Nolte, I M, Palmer, N D, Rauramaa, R, Shu, X-O, Snieder, H, Weiss, S, Wen, W, Yanek, L R, Adolfo, C, Ballantyne, C, Bielak, L, Biermasz, N R, Boerwinkle, E, Dimou, N, Eiriksdottir, G, Gao, C, Gharib, S A, Gottlieb, D J, Haba-Rubio, J, Harris, T B, Heikkinen, S, Heinzer, R, Hixson, J E, Homuth, G, Ikram, M A, Komulainen, P, Krieger, J E, Lee, J, Liu, J, Lohman, K K, Luik, A I, Mägi, R, Martin, L W, Meitinger, T, Metspalu, A, Milaneschi, Y, Nalls, M A, O'Connell, J, Peters, A, Peyser, P, Raitakari, O T, Reiner, A P, Rensen, P C N, Rice, T K, Rich, S S, Roenneberg, T, Rotter, J I, Schreiner, P J, Shikany, J, Sidney, S S, Sims, M, Sitlani, C M, Sofer, T, Strauch, K, Swertz, M A, Taylor, K D, Uitterlinden, A G, van Duijn, C M, Völzke, H, Waldenberger, M, Wallance, R B, van Dijk, K W, Yu, C, Zonderman, A B, Becker, D M, Elliott, P, Esko, T, Gieger, C, Grabe, H J, Lakka, T A, Lehtimäki, T, North, K E, Penninx, B W J H, Vollenweider, P, Wagenknecht, L E, Wu, T, Xiang, Y-B, Zheng, W, Arnett, D K, Bouchard, C, Evans, M K, Gudnason, V, Kardia, S, Kelly, T N, Kritchevsky, S B, Loos, R J F, Pereira, A C, Province, M, Psaty, B M, Rotimi, C, Zhu, X, Amin, N, Cupples, L A, Fornage, M, Fox, E F, Guo, X, Gauderman, W J, Rice, K, Kooperberg, C, Munroe, P B, Liu, C-T, Morrison, A C, Rao, D C, van Heemst, D & Redline, S 2019, ' Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration ', Nature Communications, vol. 10, no. 1, 5121 . https://doi.org/10.1038/s41467-019-12958-0
Nature communications, vol. 10, no. 1, pp. 5121
Nature Communications
Nature Communications, 2019, 10 (1), pp.5121. ⟨10.1038/s41467-019-12958-0⟩
Nature Communications, 10. NATURE PUBLISHING GROUP
Nature Communications, 10:5121. Nature Publishing Group
Nature Communications, 10(1):5121. Nature Publishing Group
Nature Communications, 10(1):5121. Nature Publishing Group UK
Noordam, R, Bos, M M, Wang, H, Winkler, T W, Bentley, A R, Kilpeläinen, T O, de Vries, P S, Sung, Y J, Schwander, K, Cade, B E, Manning, A, Aschard, H, Brown, M R, Chen, H, Franceschini, N, Musani, S K, Richard, M, Vojinovic, D, Aslibekyan, S, Bartz, T M, de las Fuentes, L, Feitosa, M, Horimoto, A R, Ilkov, M, Kho, M, Kraja, A, Li, C, Lim, E, Liu, Y, Mook-Kanamori, D O, Rankinen, T, Tajuddin, S M, van der Spek, A, Wang, Z, Marten, J, Laville, V, Alver, M, Evangelou, E, Graff, M E, He, M, Kühnel, B, Lyytikäinen, L P, Marques-Vidal, P, Nolte, I M, Palmer, N D, Rauramaa, R, Shu, X O, Snieder, H, Weiss, S & Penninx, B W J H 2019, ' Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration ', Nature Communications, vol. 10, no. 1, 5121 . https://doi.org/10.1038/s41467-019-12958-0
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.5121. ⟨10.1038/s41467-019-12958-0⟩
Noordam, R, Bos, M M, Wang, H, Winkler, T W, Bentley, A R, Kilpeläinen, T O, de Vries, P S, Sung, Y J, Schwander, K, Cade, B E, Manning, A, Aschard, H, Brown, M R, Chen, H, Franceschini, N, Musani, S K, Richard, M, Vojinovic, D, Aslibekyan, S, Bartz, T M, de Las Fuentes, L, Feitosa, M, Horimoto, A R, Ilkov, M, Kho, M, Kraja, A, Li, C, Lim, E, Liu, Y, Mook-Kanamori, D O, Rankinen, T, Tajuddin, S M, van der Spek, A, Wang, Z, Marten, J, Laville, V, Alver, M, Evangelou, E, Graff, M E, He, M, Kühnel, B, Lyytikäinen, L-P, Marques-Vidal, P, Nolte, I M, Palmer, N D, Rauramaa, R, Shu, X-O, Snieder, H, Weiss, S, Wen, W, Yanek, L R, Adolfo, C, Ballantyne, C, Bielak, L, Biermasz, N R, Boerwinkle, E, Dimou, N, Eiriksdottir, G, Gao, C, Gharib, S A, Gottlieb, D J, Haba-Rubio, J, Harris, T B, Heikkinen, S, Heinzer, R, Hixson, J E, Homuth, G, Ikram, M A, Komulainen, P, Krieger, J E, Lee, J, Liu, J, Lohman, K K, Luik, A I, Mägi, R, Martin, L W, Meitinger, T, Metspalu, A, Milaneschi, Y, Nalls, M A, O'Connell, J, Peters, A, Peyser, P, Raitakari, O T, Reiner, A P, Rensen, P C N, Rice, T K, Rich, S S, Roenneberg, T, Rotter, J I, Schreiner, P J, Shikany, J, Sidney, S S, Sims, M, Sitlani, C M, Sofer, T, Strauch, K, Swertz, M A, Taylor, K D, Uitterlinden, A G, van Duijn, C M, Völzke, H, Waldenberger, M, Wallance, R B, van Dijk, K W, Yu, C, Zonderman, A B, Becker, D M, Elliott, P, Esko, T, Gieger, C, Grabe, H J, Lakka, T A, Lehtimäki, T, North, K E, Penninx, B W J H, Vollenweider, P, Wagenknecht, L E, Wu, T, Xiang, Y-B, Zheng, W, Arnett, D K, Bouchard, C, Evans, M K, Gudnason, V, Kardia, S, Kelly, T N, Kritchevsky, S B, Loos, R J F, Pereira, A C, Province, M, Psaty, B M, Rotimi, C, Zhu, X, Amin, N, Cupples, L A, Fornage, M, Fox, E F, Guo, X, Gauderman, W J, Rice, K, Kooperberg, C, Munroe, P B, Liu, C-T, Morrison, A C, Rao, D C, van Heemst, D & Redline, S 2019, ' Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration ', Nature Communications, vol. 10, no. 1, 5121 . https://doi.org/10.1038/s41467-019-12958-0
Nature communications, vol. 10, no. 1, pp. 5121
Publisher's version (útgefin grein).
Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ance
Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ance
Autor:
Jie Zhou, Ayo P. Doumatey, Charles N. Rotimi, Guanjie Chen, Daniel Shriner, Adebowale Adeyemo, Amy R. Bentley, Kenneth Ekoru
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-6 (2021)
NPJ Genomic Medicine
NPJ Genomic Medicine
Serum bilirubin is associated with several clinical outcomes, including hypertension, type 2 diabetes (T2D), and drug metabolism. Here, we describe findings from our genome-wide association studies (GWAS) of serum (TBIL) using a generalized linear mi
Autor:
Kenneth Ekoru, Adebowale Adeyemo, Charles N. Rotimi, Mateus H. Gouveia, Karlijn Meeks, Ayo P. Doumatey, Daniel Shriner, Jie Zhou, Guanjie Chen, Amy R. Bentley
Publikováno v:
Hum Mol Genet
BackgroundSerum lipids are biomarkers of cardiometabolic disease risk, and understanding the genomic factors contributing to their distribution has been of considerable interest. Large genome-wide association studies (GWAS) have identified over 150 l
Autor:
Michèle Ramsay, Mahtaab Hayat, Robyn Kerr, Frederick J. Raal, Amy R. Bentley, Charles N. Rotimi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 2, p e0229098 (2020)
PLoS ONE, Vol 16, Iss 3, p e0249478 (2021)
PLoS ONE, Vol 15, Iss 2, p e0229098 (2020)
PLoS ONE, Vol 16, Iss 3, p e0249478 (2021)
Non-communicable diseases, including cardiovascular diseases (CVDs), are increasing in African populations. High serum low density lipoprotein cholesterol (LDL-cholesterol) levels are a known risk factor for CVDs in European populations, but the link
Autor:
Guanjie Chen, Eduardo Tarazona-Santos, Eleanor M. Simonsick, Mateus H. Gouveia, Charles N. Rotimi, Karlijn Meeks, Daniel Shriner, Maria Fernanda Lima-Costa, Mike A. Nalls, Kenneth Ekoru, Adebowale Adeyemo, Hampton L. Leonard, Amy R. Bentley
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
Genome-wide association studies (GWAS) have identified thousands of genetic loci associated with cross-sectional blood pressure (BP) traits; however, GWAS based on longitudinal BP have been underexplored. We performed ethnic-specific and trans-ethnic
Autor:
Shawneequa L. Callier, Pilar N. Ossorio, Jeroen P. Jansen, Stephanie Russo Carroll, Amy R. Bentley, Kathryn A. Phillips, Maya Wang, Yves Moreau, Kathryn Maxson Jones, Charles N. Rotimi, Nanibaa’ A. Garrison, Christopher F. Weyant, Dorothy E. Roberts, Robert Cook-Deegan, Hallam Stevens, Yaniv Erlich, Dina Zielinski
Publikováno v:
Science
Millions of people today have access to their personal genomic information. Direct-to-consumer services and integration with other “big data” increasingly commoditize what was rightly celebrated as a singular achievement in February 2001 when the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df596242ae10404c2c423f9efa8dd1ed
https://europepmc.org/articles/PMC8011351/
https://europepmc.org/articles/PMC8011351/
Autor:
Godfred Agongo, Lucas Amenga-Etego, Engelbert A. Nonterah, Cornelius Debpuur, Ananyo Choudhury, Amy R. Bentley, Abraham R. Oduro, Charles N. Rotimi, Nigel J. Crowther, Michèle Ramsay, AWI-Gen and H3Africa, H3Africa
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Frontiers in Genetics
Frontiers in Genetics
Variations in lipid levels are attributed partly to genetic factors. Genome-wide association studies (GWASs) mainly performed in European, African American and Asian cohorts have identified variants associated with LDL-C, HDL-C, total cholesterol (TC