Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Alfred Xuyang Sun"'
Publikováno v:
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.
Neuropsychiatric manifestations of coronavirus disease 2019 (COVID-19) have been increasingly recognized. However, the pathophysiology of COVID-19 in the central nervous system remains unclear. Brain organoid models derived from human pluripotent ste
Autor:
Paul M. Yen, Brijesh K. Singh, Eyleen L. K. Goh, Danlei Wang, Jin Zhou, Dongrui Ma, Jinyan Zhang, Yi Zhao, Eng-King Tan, Dongliang Ma, Hoang-Dai Tran, Alfred Xuyang Sun, Wei Zhou
Publikováno v:
Human Molecular Genetics
Coiled-coil-helix-coiled-coil-helix domain containing protein 2 (CHCHD2) mutations were linked with autosomal dominant Parkinson’s disease (PD) and recently, Alzheimer’s disease/frontotemporal dementia. In the current study, we generated isogenic
Publikováno v:
Biomaterials. 154:113-133
Three-dimensional (3D) in vitro neural tissue models provide a better recapitulation of in vivo cell-cell and cell-extracellular matrix interactions than conventional two-dimensional (2D) cultures. Therefore, the former is believed to have great pote
Publikováno v:
Annals of Clinical and Translational Neurology
The recent technology of 3D cultures of cellular aggregates derived from human stem cells have led to the emergence of tissue‐like structures of various organs including the brain. Brain organoids bear molecular and structural resemblance with deve
Autor:
Alfred Xuyang Sun, Eng-King Tan
Publikováno v:
Journal of Neuroscience Research. 96:219-221
Autor:
Levana L. Sani, Hoang-Dai Tran, Shawn Tan, Danlei Wang, Kea Joo Lee, Paul Jong Kim, Qiang Yuan, Huck-Hui Ng, Hyunsoo Shawn Je, Yi-Chun Yen, Yixin Xiao, Alfred Xuyang Sun, Bing Lim, Yong Seng Chiew, Audrey Tze Ting Khoo
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1942-1953 (2016)
SummaryGamma-aminobutyric acid (GABA)-releasing interneurons play an important modulatory role in the cortex and have been implicated in multiple neurological disorders. Patient-derived interneurons could provide a foundation for studying the pathoge